Marine Barthez1, Zehan Song1, Chih Ling Wang1, Danica Chen2. 1. Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720. 2. Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720, 119 Morgan Hall, University of California, Berkeley, CA 94720.
Abstract
PURPOSE OF REVIEW: Diet has profound impacts on health and longevity. Evidence is emerging to suggest that diet impinges upon the metabolic pathways in tissue-specific stem cells to influence health and disease. Here, we review the similarities and differences in the metabolism of stem cells from several tissues, and highlight the mitochondrial metabolic checkpoint in stem cell maintenance and aging. We discuss how diet engages the nutrient sensing metabolic pathways and impacts stem cell maintenance. Finally, we explore the therapeutic implications of dietary and metabolic regulation of stem cells. RECENT FINDINGS: Stem Cell transition from quiescence to proliferation is associated with a metabolic switch from glycolysis to mitochondrial OXPHOS and the mitochondrial metabolic checkpoint is critically controlled by the nutrient sensors SIRT2, SIRT3, and SIRT7 in hematopoietic stem cells. Intestine stem cell homeostasis during aging and in response to diet is critically dependent on fatty acid metabolism and ketone bodies and is influenced by the niche mediated by the nutrient sensor mTOR. SUMMARY: Nutrient sensing metabolic pathways critically regulate stem cell maintenance during aging and in response to diet. Elucidating the molecular mechanisms underlying dietary and metabolic regulation of stem cells provides novel insights for stem cell biology and may be targeted therapeutically to reverse stem cell aging and tissue degeneration.
PURPOSE OF REVIEW: Diet has profound impacts on health and longevity. Evidence is emerging to suggest that diet impinges upon the metabolic pathways in tissue-specific stem cells to influence health and disease. Here, we review the similarities and differences in the metabolism of stem cells from several tissues, and highlight the mitochondrial metabolic checkpoint in stem cell maintenance and aging. We discuss how diet engages the nutrient sensing metabolic pathways and impacts stem cell maintenance. Finally, we explore the therapeutic implications of dietary and metabolic regulation of stem cells. RECENT FINDINGS: Stem Cell transition from quiescence to proliferation is associated with a metabolic switch from glycolysis to mitochondrial OXPHOS and the mitochondrial metabolic checkpoint is critically controlled by the nutrient sensors SIRT2, SIRT3, and SIRT7 in hematopoietic stem cells. Intestine stem cell homeostasis during aging and in response to diet is critically dependent on fatty acid metabolism and ketone bodies and is influenced by the niche mediated by the nutrient sensor mTOR. SUMMARY: Nutrient sensing metabolic pathways critically regulate stem cell maintenance during aging and in response to diet. Elucidating the molecular mechanisms underlying dietary and metabolic regulation of stem cells provides novel insights for stem cell biology and may be targeted therapeutically to reverse stem cell aging and tissue degeneration.
Authors: Marisa M Juntilla; Vineet D Patil; Marco Calamito; Rohan P Joshi; Morris J Birnbaum; Gary A Koretzky Journal: Blood Date: 2010-03-30 Impact factor: 22.113
Authors: Maria J Rodríguez-Colman; Matthias Schewe; Maaike Meerlo; Edwin Stigter; Johan Gerrits; Mia Pras-Raves; Andrea Sacchetti; Marten Hornsveld; Koen C Oost; Hugo J Snippert; Nanda Verhoeven-Duif; Riccardo Fodde; Boudewijn M T Burgering Journal: Nature Date: 2017-03-08 Impact factor: 49.962
Authors: Chia-Wei Cheng; Gregor B Adams; Laura Perin; Min Wei; Xiaoying Zhou; Ben S Lam; Stefano Da Sacco; Mario Mirisola; David I Quinn; Tanya B Dorff; John J Kopchick; Valter D Longo Journal: Cell Stem Cell Date: 2014-06-05 Impact factor: 24.633
Authors: Sebastian Brandhorst; In Young Choi; Min Wei; Chia Wei Cheng; Sargis Sedrakyan; Gerardo Navarrete; Louis Dubeau; Li Peng Yap; Ryan Park; Manlio Vinciguerra; Stefano Di Biase; Hamed Mirzaei; Mario G Mirisola; Patra Childress; Lingyun Ji; Susan Groshen; Fabio Penna; Patrizio Odetti; Laura Perin; Peter S Conti; Yuji Ikeno; Brian K Kennedy; Pinchas Cohen; Todd E Morgan; Tanya B Dorff; Valter D Longo Journal: Cell Metab Date: 2015-06-18 Impact factor: 27.287
Authors: Francesca Pistollato; Hui-Ling Chen; Philip H Schwartz; Giuseppe Basso; David M Panchision Journal: Mol Cell Neurosci Date: 2007-04-12 Impact factor: 4.314