Investigation to Minimize Electrochemical Impedance Spectroscopy Drift.

Electrochemical impedance spectroscopy (EIS) is a technique used to characterize physiochemical processes, especially in the field of biosensors. However, EIS has been known to have reproducibility issues due to an inherent drift. When taking repeated measurements of the same exact solution using EIS, impedance measurements have an increasing trend which can be detailed by a linear slope. The reported EIS drift ranges from 0.11 to 5.5 Ω/min. We studied the drift to assist with future data interpretation and model fitting. We discovered the cleanliness and treatment of the working electrode effects EIS drift, and the minimization of the drift can occur by rinsing the working electrode in-between repeated runs.