Literature DB >> 33774735

Solving the migration-recombination equation from a genealogical point of view.

F Alberti1, E Baake2, I Letter3, S Martínez4.   

Abstract

We consider the discrete-time migration-recombination equation, a deterministic, nonlinear dynamical system that describes the evolution of the genetic type distribution of a population evolving under migration and recombination in a law of large numbers setting. We relate this dynamics (forward in time) to a Markov chain, namely a labelled partitioning process, backward in time. This way, we obtain a stochastic representation of the solution of the migration-recombination equation. As a consequence, one obtains an explicit solution of the nonlinear dynamics, simply in terms of powers of the transition matrix of the Markov chain. The limiting and quasi-limiting behaviour of the Markov chain are investigated, which gives immediate access to the asymptotic behaviour of the dynamical system. We finally sketch the analogous situation in continuous time.

Entities:  

Keywords:  Ancestral recombination graph; Duality; Haldane linearisation; Labelled partitioning process; Migration–recombination equation; Quasi-stationarity

Year:  2021        PMID: 33774735      PMCID: PMC8004498          DOI: 10.1007/s00285-021-01584-4

Source DB:  PubMed          Journal:  J Math Biol        ISSN: 0303-6812            Impact factor:   2.259


  11 in total

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Authors:  T Nagylaki; J Hofbauer; P Brunovský
Journal:  J Math Biol       Date:  1999-02       Impact factor: 2.259

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Authors:  Mareike Esser; Sebastian Probst; Ellen Baake
Journal:  J Math Biol       Date:  2015-11-06       Impact factor: 2.259

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Authors:  Paul F Slade; John Wakeley
Journal:  Genetics       Date:  2004-11-01       Impact factor: 4.562

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Authors:  Frederick A Matsen; John Wakeley
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Authors:  Reinhard Bürger
Journal:  J Math Biol       Date:  2008-11-21       Impact factor: 2.259

7.  Single-crossover recombination in discrete time.

Authors:  Ute von Wangenheim; Ellen Baake; Michael Baake
Journal:  J Math Biol       Date:  2009-07-28       Impact factor: 2.259

8.  Ancestral inference from samples of DNA sequences with recombination.

Authors:  R C Griffiths; P Marjoram
Journal:  J Comput Biol       Date:  1996       Impact factor: 1.479

9.  CLOSED-FORM ASYMPTOTIC SAMPLING DISTRIBUTIONS UNDER THE COALESCENT WITH RECOMBINATION FOR AN ARBITRARY NUMBER OF LOCI.

Authors:  Anand Bhaskar; Yun S Song
Journal:  Adv Appl Probab       Date:  2012-06       Impact factor: 0.690

10.  Single-crossover recombination and ancestral recombination trees.

Authors:  Ellen Baake; Ute von Wangenheim
Journal:  J Math Biol       Date:  2013-04-06       Impact factor: 2.259

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