Quanfu Xu1, Yuli Yang1, Jianwen Hou1, Taizhong Chen1, Yudong Fei1, Qian Wang1, Qing Zhou1, Wei Li1, Jing Ren2, Yi-Gang Li3. 1. Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, China. 2. School of Physical Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai, 201210, China. renjing@shanghaitech.edu.cn. 3. Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, China. liyigang@xinhuamed.com.cn.
Abstract
BACKGROUND: End-stage heart failure is a major risk of mortality. The conductive super-aligned carbon nanotubes sheets (SA-CNTs) has been applied to restore the structure and function of injured myocardium through tissue engineering, and developed as efficient cardiac pacing electrodes. However, the interfacial interaction between SA-CNTs and the surface cells is unclear, and it remains challenge to restore the diminished contraction for a seriously damaged heart. RESULTS: A concept of a multifunctional power assist system (MPS) capable of multipoint pacing and contraction assisting is proposed. This device is designed to work with the host heart and does not contact blood, thus avoiding long-term anticoagulation required in current therapies. Pacing electrode constructed by SA--CNTs promotes the epithelial-mesenchymal transition and directs the migration of pro-regenerative epicardial cells. Meanwhile, the power assist unit reveals an excellent frequency response to alternating voltage, with natural heart mimicked systolic/diastolic amplitudes. Moreover, this system exhibits an excellent pacing when attached to the surface of a rabbit heart, and presents nice biocompatibility in both in vitro and in vivo evaluation. CONCLUSIONS: This MPS provides a promising non-blood contact strategy to restore in situ the normal blood-pumping function of a failed heart.
BACKGROUND: End-stage heart failure is a major risk of mortality. The conductive super-aligned carbon nanotubes sheets (SA-CNTs) has been applied to restore the structure and function of injured myocardium through tissue engineering, and developed as efficient cardiac pacing electrodes. However, the interfacial interaction between SA-CNTs and the surface cells is unclear, and it remains challenge to restore the diminished contraction for a seriously damaged heart. RESULTS: A concept of a multifunctional power assist system (MPS) capable of multipoint pacing and contraction assisting is proposed. This device is designed to work with the host heart and does not contact blood, thus avoiding long-term anticoagulation required in current therapies. Pacing electrode constructed by SA--CNTs promotes the epithelial-mesenchymal transition and directs the migration of pro-regenerative epicardial cells. Meanwhile, the power assist unit reveals an excellent frequency response to alternating voltage, with natural heart mimicked systolic/diastolic amplitudes. Moreover, this system exhibits an excellent pacing when attached to the surface of a rabbit heart, and presents nice biocompatibility in both in vitro and in vivo evaluation. CONCLUSIONS: This MPS provides a promising non-blood contact strategy to restore in situ the normal blood-pumping function of a failed heart.
Authors: Jesus Paez-Mayorga; Gustavo Hernández-Vargas; Guillermo U Ruiz-Esparza; Hafiz M N Iqbal; Xichi Wang; Yu Shrike Zhang; Roberto Parra-Saldivar; Ali Khademhosseini Journal: Adv Healthc Mater Date: 2018-05-08 Impact factor: 9.933
Authors: Josef Stehlik; Jon Kobashigawa; Sharon A Hunt; Hermann Reichenspurner; James K Kirklin Journal: Circulation Date: 2018-01-02 Impact factor: 29.690