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Literature DB >> 33769165

Drugging multiple same-allele driver mutations in cancer.

Ruth Nussinov^1,2, Mingzhen Zhang¹, Ryan Maloney³, Hyunbum Jang¹.

Abstract

Entities: Chemical

Keywords: Drug resistance; activating mutations; cancer; double mutations; drug discovery; k-ras; pi3k; signaling

Mesh：

Year: 2021 PMID： 33769165 PMCID： PMC8298276 DOI： 10.1080/17460441.2021.1905628

Source DB: PubMed Journal: Expert Opin Drug Discov ISSN： 1746-0441 Impact factor: 7.050

× No keyword cloud information.

29 in total

1. Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors.

Authors: Pedram Razavi; Jared L Johnson; Hong Shao; Neil Vasan; Hardik Shah; Alesia Antoine; Erik Ladewig; Alexander Gorelick; Ting-Yu Lin; Eneda Toska; Guotai Xu; Abiha Kazmi; Matthew T Chang; Barry S Taylor; Maura N Dickler; Komal Jhaveri; Sarat Chandarlapaty; Raul Rabadan; Ed Reznik; Melissa L Smith; Robert Sebra; Frauke Schimmoller; Timothy R Wilson; Lori S Friedman; Lewis C Cantley; Maurizio Scaltriti; José Baselga
Journal: Science Date: 2019-11-08 Impact factor: 47.728

2. Comprehensive Characterization of Cancer Driver Genes and Mutations.

Authors: Matthew H Bailey; Collin Tokheim; Eduard Porta-Pardo; Sohini Sengupta; Denis Bertrand; Amila Weerasinghe; Antonio Colaprico; Michael C Wendl; Jaegil Kim; Brendan Reardon; Patrick Kwok-Shing Ng; Kang Jin Jeong; Song Cao; Zixing Wang; Jianjiong Gao; Qingsong Gao; Fang Wang; Eric Minwei Liu; Loris Mularoni; Carlota Rubio-Perez; Niranjan Nagarajan; Isidro Cortés-Ciriano; Daniel Cui Zhou; Wen-Wei Liang; Julian M Hess; Venkata D Yellapantula; David Tamborero; Abel Gonzalez-Perez; Chayaporn Suphavilai; Jia Yu Ko; Ekta Khurana; Peter J Park; Eliezer M Van Allen; Han Liang; Michael S Lawrence; Adam Godzik; Nuria Lopez-Bigas; Josh Stuart; David Wheeler; Gad Getz; Ken Chen; Alexander J Lazar; Gordon B Mills; Rachel Karchin; Li Ding
Journal: Cell Date: 2018-04-05 Impact factor: 41.582

Review 3. Bioinformatics Approaches for Anti-cancer Drug Discovery.

Authors: Kening Li; Yuxin Du; Lu Li; Dong-Qing Wei
Journal: Curr Drug Targets Date: 2020 Impact factor: 3.465

4. AlloSigMA 2: paving the way to designing allosteric effectors and to exploring allosteric effects of mutations.

Authors: Zhen Wah Tan; Enrico Guarnera; Wei-Ven Tee; Igor N Berezovsky
Journal: Nucleic Acids Res Date: 2020-07-02 Impact factor: 16.971

5. Architecture of human Rag GTPase heterodimers and their complex with mTORC1.

Authors: Madhanagopal Anandapadamanaban; Glenn R Masson; Olga Perisic; Alex Berndt; Jonathan Kaufman; Chris M Johnson; Balaji Santhanam; Kacper B Rogala; David M Sabatini; Roger L Williams
Journal: Science Date: 2019-10-11 Impact factor: 47.728

Review 6. PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective.

Authors: Mingzhen Zhang; Hyunbum Jang; Ruth Nussinov
Journal: Cancer Res Date: 2020-10-12 Impact factor: 13.312

7. Landscape and function of multiple mutations within individual oncogenes.

Authors: Yuki Saito; Junji Koya; Mitsugu Araki; Yasunori Kogure; Sumito Shingaki; Mariko Tabata; Marni B McClure; Kota Yoshifuji; Shigeyuki Matsumoto; Yuta Isaka; Hiroko Tanaka; Takanori Kanai; Satoru Miyano; Yuichi Shiraishi; Yasushi Okuno; Keisuke Kataoka
Journal: Nature Date: 2020-04-08 Impact factor: 69.504

8. A functional genetic screen defines the AKT-induced senescence signaling network.

Authors: Keefe T Chan; Shaun Blake; Haoran Zhu; Jian Kang; Anna S Trigos; Piyush B Madhamshettiwar; Jeannine Diesch; Lassi Paavolainen; Peter Horvath; Ross D Hannan; Amee J George; Elaine Sanij; Katherine M Hannan; Kaylene J Simpson; Richard B Pearson
Journal: Cell Death Differ Date: 2019-07-08 Impact factor: 15.828

Drugging multiple same-allele driver mutations in cancer.

1. Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors.

2. Comprehensive Characterization of Cancer Driver Genes and Mutations.

Review 3. Bioinformatics Approaches for Anti-cancer Drug Discovery.

4. AlloSigMA 2: paving the way to designing allosteric effectors and to exploring allosteric effects of mutations.

5. Architecture of human Rag GTPase heterodimers and their complex with mTORC1.

Review 6. PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective.

7. Landscape and function of multiple mutations within individual oncogenes.

8. A functional genetic screen defines the AKT-induced senescence signaling network.

9. Comprehensive Analysis of Differential Gene Expression to Identify Common Gene Signatures in Multiple Cancers.

Review 10. PI3K inhibitors: review and new strategies.

Review 1. Allostery, and how to define and measure signal transduction.

Review 2. Neurodevelopmental disorders, immunity, and cancer are connected.

Review 3. Allostery: Allosteric Cancer Drivers and Innovative Allosteric Drugs.

Review 4. Anticancer drug resistance: An update and perspective.

Review 5. Mechanism of activation and the rewired network: New drug design concepts.