Literature DB >> 33767200

The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization.

Jing Zou1, Xuping Xie1, Camila R Fontes-Garfias1, Kena A Swanson2, Isis Kanevsky2, Kristin Tompkins2, Mark Cutler2, David Cooper2, Philip R Dormitzer3, Pei-Yong Shi4,5,6,7.   

Abstract

Initial COVID-19 vaccine candidates were based on the original sequence of SARS-CoV-2. However, the virus has since accumulated mutations, among which the spike D614G is dominant in circulating virus, raising questions about potential virus escape from vaccine-elicited immunity. Here, we report that the D614G mutation modestly reduced (1.7-2.4-fold) SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.

Entities:  

Year:  2021        PMID： 33767200      PMCID： PMC7994717          DOI： 10.1038/s41541-021-00313-8

Source DB:  PubMed          Journal:  NPJ Vaccines        ISSN： 2059-0105            Impact factor:   7.344


  15 in total

1.  Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera.

Authors:  Xuping Xie; Yang Liu; Jianying Liu; Xianwen Zhang; Jing Zou; Camila R Fontes-Garfias; Hongjie Xia; Kena A Swanson; Mark Cutler; David Cooper; Vineet D Menachery; Scott C Weaver; Philip R Dormitzer; Pei-Yong Shi
Journal:  Nat Med       Date:  2021-02-08       Impact factor: 53.440

Review 2.  Engineering SARS-CoV-2 using a reverse genetic system.

Authors:  Xuping Xie; Kumari G Lokugamage; Xianwen Zhang; Michelle N Vu; Antonio E Muruato; Vineet D Menachery; Pei-Yong Shi
Journal:  Nat Protoc       Date:  2021-01-29       Impact factor: 13.491

Review 3.  Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity.

Authors:  Mark R Denison; Rachel L Graham; Eric F Donaldson; Lance D Eckerle; Ralph S Baric
Journal:  RNA Biol       Date:  2011-03-01       Impact factor: 4.652

4.  Neutralizing Activity of BNT162b2-Elicited Serum.

Authors:  Yang Liu; Jianying Liu; Hongjie Xia; Xianwen Zhang; Camila R Fontes-Garfias; Kena A Swanson; Hui Cai; Ritu Sarkar; Wei Chen; Mark Cutler; David Cooper; Scott C Weaver; Alexander Muik; Ugur Sahin; Kathrin U Jansen; Xuping Xie; Philip R Dormitzer; Pei-Yong Shi
Journal:  N Engl J Med       Date:  2021-03-08       Impact factor: 91.245

5.  An Infectious cDNA Clone of SARS-CoV-2.

Authors:  Xuping Xie; Antonio Muruato; Kumari G Lokugamage; Krishna Narayanan; Xianwen Zhang; Jing Zou; Jianying Liu; Craig Schindewolf; Nathen E Bopp; Patricia V Aguilar; Kenneth S Plante; Scott C Weaver; Shinji Makino; James W LeDuc; Vineet D Menachery; Pei-Yong Shi
Journal:  Cell Host Microbe       Date:  2020-04-13       Impact factor: 21.023

6.  A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation.

Authors:  Antonio E Muruato; Camila R Fontes-Garfias; Ping Ren; Mariano A Garcia-Blanco; Vineet D Menachery; Xuping Xie; Pei-Yong Shi
Journal:  Nat Commun       Date:  2020-08-13       Impact factor: 14.919

7.  Transmission of SARS-CoV-2 on mink farms between humans and mink and back to humans.

Authors:  Bas B Oude Munnink; Reina S Sikkema; David F Nieuwenhuijse; Robert Jan Molenaar; Emmanuelle Munger; Richard Molenkamp; Arco van der Spek; Paulien Tolsma; Ariene Rietveld; Miranda Brouwer; Noortje Bouwmeester-Vincken; Frank Harders; Renate Hakze-van der Honing; Marjolein C A Wegdam-Blans; Ruth J Bouwstra; Corine GeurtsvanKessel; Annemiek A van der Eijk; Francisca C Velkers; Lidwien A M Smit; Arjan Stegeman; Wim H M van der Poel; Marion P G Koopmans
Journal:  Science       Date:  2020-11-10       Impact factor: 47.728

8.  D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization.

Authors:  Drew Weissman; Mohamad-Gabriel Alameh; Thushan de Silva; Paul Collini; Hailey Hornsby; Rebecca Brown; Celia C LaBranche; Robert J Edwards; Laura Sutherland; Sampa Santra; Katayoun Mansouri; Sophie Gobeil; Charlene McDanal; Norbert Pardi; Nick Hengartner; Paulo J C Lin; Ying Tam; Pamela A Shaw; Mark G Lewis; Carsten Boesler; Uğur Şahin; Priyamvada Acharya; Barton F Haynes; Bette Korber; David C Montefiori
Journal:  Cell Host Microbe       Date:  2020-12-01       Impact factor: 31.316

9.  Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.

Authors:  Bette Korber; Will M Fischer; Sandrasegaram Gnanakaran; Hyejin Yoon; James Theiler; Werner Abfalterer; Nick Hengartner; Elena E Giorgi; Tanmoy Bhattacharya; Brian Foley; Kathryn M Hastie; Matthew D Parker; David G Partridge; Cariad M Evans; Timothy M Freeman; Thushan I de Silva; Charlene McDanal; Lautaro G Perez; Haili Tang; Alex Moon-Walker; Sean P Whelan; Celia C LaBranche; Erica O Saphire; David C Montefiori
Journal:  Cell       Date:  2020-07-03       Impact factor: 66.850

10.  Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.

Authors:  Leonid Yurkovetskiy; Xue Wang; Kristen E Pascal; Christopher Tomkins-Tinch; Thomas P Nyalile; Yetao Wang; Alina Baum; William E Diehl; Ann Dauphin; Claudia Carbone; Kristen Veinotte; Shawn B Egri; Stephen F Schaffner; Jacob E Lemieux; James B Munro; Ashique Rafique; Abhi Barve; Pardis C Sabeti; Christos A Kyratsous; Natalya V Dudkina; Kuang Shen; Jeremy Luban
Journal:  Cell       Date:  2020-09-15       Impact factor: 66.850
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  18 in total

1.  SARS-CoV-2 variants and vaccination.

Authors:  Yang Liu; Jianying Liu; Pei-Yong Shi
Journal:  Zoonoses (Burlingt)       Date:  2022-02-08

2.  Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera.

Authors:  Raveen Rathnasinghe; Sonia Jangra; Chengjin Ye; Anastasija Cupic; Gagandeep Singh; Carles Martínez-Romero; Lubbertus C F Mulder; Thomas Kehrer; Soner Yildiz; Angela Choi; Stephen T Yeung; Ignacio Mena; Virginia Gillespie; Jana De Vrieze; Sadaf Aslam; Daniel Stadlbauer; David A Meekins; Chester D McDowell; Velmurugan Balaraman; Michael J Corley; Juergen A Richt; Bruno G De Geest; Lisa Miorin; Florian Krammer; Luis Martinez-Sobrido; Viviana Simon; Adolfo García-Sastre; Michael Schotsaert
Journal:  Nat Commun       Date:  2022-07-07       Impact factor: 17.694

3.  Chimeric Antigen by the Fusion of SARS-CoV-2 Receptor Binding Domain with the Extracellular Domain of Human CD154: A Promising Improved Vaccine Candidate.

Authors:  Ileanet Ávalos; Thailin Lao; Elsa María Rodríguez; Yasser Zamora; Alianet Rodríguez; Ailyn Ramón; Gilda Lemos; Ania Cabrales; Monica Bequet-Romero; Dionne Casillas; Ivan Andújar; Luis Ariel Espinosa; Luis Javier González; Yanitza Alvarez; Yamila Carpio; Mario Pablo Estrada
Journal:  Vaccines (Basel)       Date:  2022-06-03

4.  Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity.

Authors:  Carolina Lucas; Chantal B F Vogels; Inci Yildirim; Jessica E Rothman; Peiwen Lu; Valter Monteiro; Jeff R Gehlhausen; Melissa Campbell; Julio Silva; Alexandra Tabachnikova; Mario A Peña-Hernandez; M Catherine Muenker; Mallery I Breban; Joseph R Fauver; Subhasis Mohanty; Jiefang Huang; Albert C Shaw; Albert I Ko; Saad B Omer; Nathan D Grubaugh; Akiko Iwasaki
Journal:  Nature       Date:  2021-10-11       Impact factor: 69.504

Review 5.  Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy.

Authors:  Yizhou Jiang; Limor Rubin; Tangming Peng; Linlin Liu; Xingan Xing; Philip Lazarovici; Wenhua Zheng
Journal:  Int J Biol Sci       Date:  2022-01-01       Impact factor: 6.580

Review 6.  The biological and clinical significance of emerging SARS-CoV-2 variants.

Authors:  Kaiming Tao; Philip L Tzou; Janin Nouhin; Ravindra K Gupta; Tulio de Oliveira; Sergei L Kosakovsky Pond; Daniela Fera; Robert W Shafer
Journal:  Nat Rev Genet       Date:  2021-09-17       Impact factor: 53.242

Review 7.  The intestinal microbiota and improving the efficacy of COVID-19 vaccinations.

Authors:  Jiezhong Chen; Luis Vitetta; Jeremy D Henson; Sean Hall
Journal:  J Funct Foods       Date:  2021-11-10       Impact factor: 4.451

Review 8.  A Comprehensive Review of COVID-19 Virology, Vaccines, Variants, and Therapeutics.

Authors:  Lauren Forchette; William Sebastian; Tuoen Liu
Journal:  Curr Med Sci       Date:  2021-07-09

9.  Landscape-Based Mutational Sensitivity Cartography and Network Community Analysis of the SARS-CoV-2 Spike Protein Structures: Quantifying Functional Effects of the Circulating D614G Variant.

Authors:  Gennady M Verkhivker; Steve Agajanian; Deniz Yasar Oztas; Grace Gupta
Journal:  ACS Omega       Date:  2021-06-09

Review 10.  Potency of BNT162b2 and mRNA-1273 vaccine-induced neutralizing antibodies against severe acute respiratory syndrome-CoV-2 variants of concern: A systematic review of in vitro studies.

Authors:  Maryam Noori; Seyed Aria Nejadghaderi; Shahnam Arshi; Kristin Carson-Chahhoud; Khalil Ansarin; Ali-Asghar Kolahi; Saeid Safiri
Journal:  Rev Med Virol       Date:  2021-07-19       Impact factor: 11.043
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