Literature DB >> 33558724

Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera.

Xuping Xie1, Yang Liu1, Jianying Liu2,3, Xianwen Zhang1, Jing Zou1, Camila R Fontes-Garfias1, Hongjie Xia1, Kena A Swanson4, Mark Cutler4, David Cooper4, Vineet D Menachery2,3, Scott C Weaver2,3, Philip R Dormitzer5, Pei-Yong Shi6,7,8,9,10.   

Abstract

We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.

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Year:  2021        PMID： 33558724     DOI： 10.1038/s41591-021-01270-4

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  252 in total

1.  Bioinformatics for the Origin and Evolution of Viruses.

Authors:  Jiajia Chen; Yuxin Zhang; Bairong Shen
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 2.622

2.  SARS-CoV-2 Variants: A Synopsis of In Vitro Efficacy Data of Convalescent Plasma, Currently Marketed Vaccines, and Monoclonal Antibodies.

Authors:  Daniele Focosi; Marco Tuccori; Andreina Baj; Fabrizio Maggi
Journal:  Viruses       Date:  2021-06-23       Impact factor: 5.048

3.  Multiplex SARS-CoV-2 Genotyping Reverse Transcriptase PCR for Population-Level Variant Screening and Epidemiologic Surveillance.

Authors:  Hannah Wang; Jacob A Miller; Michelle Verghese; Mamdouh Sibai; Daniel Solis; Kenji O Mfuh; Becky Jiang; Naomi Iwai; Marilyn Mar; ChunHong Huang; Fumiko Yamamoto; Malaya K Sahoo; James Zehnder; Benjamin A Pinsky
Journal:  J Clin Microbiol       Date:  2021-07-19       Impact factor: 5.948

Review 4.  Making sense of spike D614G in SARS-CoV-2 transmission.

Authors:  Aria C Shi; Xuping Xie
Journal:  Sci China Life Sci       Date:  2021-02-04       Impact factor: 6.038

5.  Emergence and Spread of SARS-CoV-2 Lineages B.1.1.7 and P.1 in Italy.

Authors:  Francesca Di Giallonardo; Ilaria Puglia; Valentina Curini; Cesare Cammà; Iolanda Mangone; Paolo Calistri; Joanna C A Cobbin; Edward C Holmes; Alessio Lorusso
Journal:  Viruses       Date:  2021-04-29       Impact factor: 5.048

Review 6.  mRNA-Based Vaccines.

Authors:  Frank Kowalzik; Daniel Schreiner; Christian Jensen; Daniel Teschner; Stephan Gehring; Fred Zepp
Journal:  Vaccines (Basel)       Date:  2021-04-15

Review 7.  Fast-spreading SARS-CoV-2 variants: challenges to and new design strategies of COVID-19 vaccines.

Authors:  Weilin Zhou; Wei Wang
Journal:  Signal Transduct Target Ther       Date:  2021-06-09

8.  E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil.

Authors:  Patrícia Aline Gröhs Ferrareze; Vinícius Bonetti Franceschi; Amanda de Menezes Mayer; Gabriel Dickin Caldana; Ricardo Ariel Zimerman; Claudia Elizabeth Thompson
Journal:  Infect Genet Evol       Date:  2021-05-25       Impact factor: 4.393

Review 9.  SARS-CoV-2 vaccines - the biggest medical research project of the 21st century.

Authors:  Drishya Kurup; Matthias J Schnell
Journal:  Curr Opin Virol       Date:  2021-05-04       Impact factor: 7.121

Review 10.  SARS-CoV-2 variants, spike mutations and immune escape.

Authors:  William T Harvey; Alessandro M Carabelli; Ben Jackson; Ravindra K Gupta; Emma C Thomson; Ewan M Harrison; Catherine Ludden; Richard Reeve; Andrew Rambaut; Sharon J Peacock; David L Robertson
Journal:  Nat Rev Microbiol       Date:  2021-06-01       Impact factor: 78.297
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