| Literature DB >> 33767199 |
Bénedith Oben1,2, Guy Froyen2,3, Kylee H Maclachlan4, Daniel Leongamornlert5, Federico Abascal5, Binbin Zheng-Lin4, Venkata Yellapantula4, Andriy Derkach6, Ellen Geerdens3, Benjamin T Diamond4, Ingrid Arijs2,7,8, Brigitte Maes3, Kimberly Vanhees2,9, Malin Hultcrantz4, Elisabet E Manasanch10, Dickran Kazandjian11, Alexander Lesokhin4, Ahmet Dogan12, Yanming Zhang13, Aneta Mikulasova14, Brian Walker15, Gareth Morgan16, Peter J Campbell5, Ola Landgren17, Jean-Luc Rummens1,2,9, Niccolò Bolli18,19, Francesco Maura20,21.
Abstract
Multiple myeloma (MM) is consistently preceded by precursor conditions recognized clinically as monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM). We interrogate the whole genome sequence (WGS) profile of 18 MGUS and compare them with those from 14 SMMs and 80 MMs. We show that cases with a non-progressing, clinically stable myeloma precursor condition (n = 15) are characterized by later initiation in the patient's life and by the absence of myeloma defining genomic events including: chromothripsis, templated insertions, mutations in driver genes, aneuploidy, and canonical APOBEC mutational activity. This data provides evidence that WGS can be used to recognize two biologically and clinically distinct myeloma precursor entities that are either progressive or stable.Entities:
Mesh：
Year: 2021 PMID： 33767199 PMCID： PMC7994386 DOI： 10.1038/s41467-021-22140-0
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919