| Literature DB >> 33765427 |
Firat Kara1, Michael E Belloy2, Rick Voncken2, Zahra Sarwari2, Yadav Garima2, Cynthia Anckaerts2, An Langbeen3, Valerie Leysen4, Disha Shah2, Jules Jacobs5, Julie Hamaide2, Peter Bols3, Johan Van Audekerke2, Jasmijn Daans6, Caroline Guglielmetti7, Kejal Kantarci8, Vincent Prevot4, Steffen Roßner9, Peter Ponsaerts6, Annemie Van der Linden2, Marleen Verhoye2.
Abstract
Premenopausal bilateral ovariectomy is considered to be one of the risk factors of Alzheimer's disease (AD). However, the underlying mechanisms remain unclear. Here, we aimed to investigate long-term neurological consequences of ovariectomy in a rodent AD model, TG2576 (TG), and wild-type mice (WT) that underwent an ovariectomy or sham-operation, using in vivo MRI biomarkers. An increase in osmoregulation and energy metabolism biomarkers in the hypothalamus, a decrease in white matter integrity, and a decrease in the resting-state functional connectivity was observed in ovariectomized TG mice compared to sham-operated TG mice. In addition, we observed an increase in functional connectivity in ovariectomized WT mice compared to sham-operated WT mice. Furthermore, genotype (TG vs. WT) effects on imaging markers and GFAP immunoreactivity levels were observed, but there was no effect of interaction (Genotype × Surgery) on amyloid-beta-and GFAP immunoreactivity levels. Taken together, our results indicated that both genotype and ovariectomy alters imaging biomarkers associated with AD.Entities:
Keywords: Alzheimer's disease; Astrocytes; Diffusion Tensor Imaging; Tg2576 mice; amyloid-beta (Aβ); functional connectivity; human APP Swedish; magnetic resonance spectroscopy; ovarian hormones; ovariectomy; resting state fMRI
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Year: 2021 PMID： 33765427 PMCID： PMC8312737 DOI： 10.1016/j.neurobiolaging.2021.02.011
Source DB: PubMed Journal: Neurobiol Aging ISSN： 0197-4580 Impact factor: 4.673