Literature DB >> 33763859

GOLPH3 tunes up glycosphingolipid biosynthesis for cell growth.

Wilhelm Palm1.   

Abstract

Glycosphingolipids are a structurally diverse class of lipids that regulate plasma membrane protein function. Rizzo et al (2021) now show that GOLPH3 promotes intra-Golgi transport of several enzymes that function at branching points of sphingolipid biosynthesis. By regulating the cellular sphingolipidome, GOLPH3 promotes growth factor signaling and cell proliferation, which may explain its oncogenic properties.
© 2021 The Author.

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Year:  2021        PMID： 33763859      PMCID： PMC8047436          DOI： 10.15252/embj.2021108070

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  9 in total

1.  Cell membranes: the lipid perspective.

Authors:  Unal Coskun; Kai Simons
Journal:  Structure       Date:  2011-11-09       Impact factor: 5.006

2.  Signal-mediated dynamic retention of glycosyltransferases in the Golgi.

Authors:  Linna Tu; William C S Tai; Lu Chen; David K Banfield
Journal:  Science       Date:  2008-07-18       Impact factor: 47.728

Review 3.  Golgi compartmentation and identity.

Authors:  Effrosyni Papanikou; Benjamin S Glick
Journal:  Curr Opin Cell Biol       Date:  2014-05-17       Impact factor: 8.382

4.  Overexpression of GOLPH3 promotes proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor.

Authors:  Zhaolei Zeng; Huanxin Lin; Xiaohui Zhao; Guanglin Liu; Xi Wang; Ruihua Xu; Kun Chen; Jun Li; Libing Song
Journal:  Clin Cancer Res       Date:  2012-06-06       Impact factor: 12.531

5.  Golgi phosphoprotein 3 triggers signal-mediated incorporation of glycosyltransferases into coatomer-coated (COPI) vesicles.

Authors:  Elias S P Eckert; Ingeborg Reckmann; Andrea Hellwig; Simone Röhling; Assou El-Battari; Felix T Wieland; Vincent Popoff
Journal:  J Biol Chem       Date:  2014-09-22       Impact factor: 5.157

Review 6.  Glycosphingolipids: synthesis and functions.

Authors:  Giovanni D'Angelo; Serena Capasso; Lucia Sticco; Domenico Russo
Journal:  FEBS J       Date:  2013-10-25       Impact factor: 5.542

7.  GOLPH3 tunes up glycosphingolipid biosynthesis for cell growth.

Authors:  Wilhelm Palm
Journal:  EMBO J       Date:  2021-03-25       Impact factor: 11.598

8.  Golgi maturation-dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3.

Authors:  Riccardo Rizzo; Domenico Russo; Kazuo Kurokawa; Pranoy Sahu; Bernadette Lombardi; Domenico Supino; Mikhail A Zhukovsky; Anthony Vocat; Prathyush Pothukuchi; Vidya Kunnathully; Laura Capolupo; Gaelle Boncompain; Carlo Vitagliano; Federica Zito Marino; Gabriella Aquino; Daniela Montariello; Petra Henklein; Luigi Mandrich; Gerardo Botti; Henrik Clausen; Ulla Mandel; Toshiyuki Yamaji; Kentaro Hanada; Alfredo Budillon; Franck Perez; Seetharaman Parashuraman; Yusuf A Hannun; Akihiko Nakano; Daniela Corda; Giovanni D'Angelo; Alberto Luini
Journal:  EMBO J       Date:  2021-03-22       Impact factor: 11.598

9.  GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer.

Authors:  Kenneth L Scott; Omar Kabbarah; Mei-Chih Liang; Elena Ivanova; Valsamo Anagnostou; Joyce Wu; Sabin Dhakal; Min Wu; Shujuan Chen; Tamar Feinberg; Joseph Huang; Abdel Saci; Hans R Widlund; David E Fisher; Yonghong Xiao; David L Rimm; Alexei Protopopov; Kwok-Kin Wong; Lynda Chin
Journal:  Nature       Date:  2009-06-25       Impact factor: 49.962
  9 in total
  2 in total

1.  GOLPH3 tunes up glycosphingolipid biosynthesis for cell growth.

Authors:  Wilhelm Palm
Journal:  EMBO J       Date:  2021-03-25       Impact factor: 11.598

Review 2.  Role of Globotriaosylceramide in Physiology and Pathology.

Authors:  Ana Beatriz Celi; Jorge Goldstein; María Victoria Rosato-Siri; Alipio Pinto
Journal:  Front Mol Biosci       Date:  2022-02-23
  2 in total

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