BACKGROUND: In March 2020, the World Health Organization declared the coronavirus disease 2019 as a global pandemic. Though antiviral drugs and antimalarial drugs are considered treatment options for treating coronavirus disease 2019 (COVID-19), no specific antivirals are currently available for its treatment. Efficient use of drug discovery approaches including repurposing or repositioning of drugs used in the treatment of severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) is considered recently. The widespread application of corticosteroid therapy in COVID-19 should be backed with careful documented pragmatic research of its use in this context. MAIN BODY: This article aims to analyze various trials registered across the globe providing an overall picture of the use of corticosteroids in the treatment of COVID-19. An extensive search was conducted on the clinical trial registries around the world to identify all the trials reporting information regarding the use of corticosteroids in COVID-19. Our initial search returned 231 trials, out of which 60 trials were finally included in the analysis. Fifty-six studies were interventional trials, and all the trials had clearly defined primary and secondary outcomes of interest, of which only 11 trials had evaluation of respiratory rate as one of their outcomes. CONCLUSION: Few preliminary trial findings show promising results and recommend the use of methylprednisolone and dexamethasone in the severe form of the disease; however, there is insufficient data to prove its benefits over its risks. Routine use of corticosteroids should be favored only after a better insight is obtained, with the completion of these trials.
BACKGROUND: In March 2020, the World Health Organization declared the coronavirus disease 2019 as a global pandemic. Though antiviral drugs and antimalarial drugs are considered treatment options for treating coronavirus disease 2019 (COVID-19), no specific antivirals are currently available for its treatment. Efficient use of drug discovery approaches including repurposing or repositioning of drugs used in the treatment of severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) is considered recently. The widespread application of corticosteroid therapy in COVID-19 should be backed with careful documented pragmatic research of its use in this context. MAIN BODY: This article aims to analyze various trials registered across the globe providing an overall picture of the use of corticosteroids in the treatment of COVID-19. An extensive search was conducted on the clinical trial registries around the world to identify all the trials reporting information regarding the use of corticosteroids in COVID-19. Our initial search returned 231 trials, out of which 60 trials were finally included in the analysis. Fifty-six studies were interventional trials, and all the trials had clearly defined primary and secondary outcomes of interest, of which only 11 trials had evaluation of respiratory rate as one of their outcomes. CONCLUSION: Few preliminary trial findings show promising results and recommend the use of methylprednisolone and dexamethasone in the severe form of the disease; however, there is insufficient data to prove its benefits over its risks. Routine use of corticosteroids should be favored only after a better insight is obtained, with the completion of these trials.
Authors: Karina Martinez-Mayorga; Abraham Madariaga-Mazon; José L Medina-Franco; Gerald Maggiora Journal: Expert Opin Drug Discov Date: 2020-01-22 Impact factor: 6.098
Authors: Derek C Angus; Lennie Derde; Farah Al-Beidh; Djillali Annane; Yaseen Arabi; Abigail Beane; Wilma van Bentum-Puijk; Lindsay Berry; Zahra Bhimani; Marc Bonten; Charlotte Bradbury; Frank Brunkhorst; Meredith Buxton; Adrian Buzgau; Allen C Cheng; Menno de Jong; Michelle Detry; Lise Estcourt; Mark Fitzgerald; Herman Goossens; Cameron Green; Rashan Haniffa; Alisa M Higgins; Christopher Horvat; Sebastiaan J Hullegie; Peter Kruger; Francois Lamontagne; Patrick R Lawler; Kelsey Linstrum; Edward Litton; Elizabeth Lorenzi; John Marshall; Daniel McAuley; Anna McGlothin; Shay McGuinness; Bryan McVerry; Stephanie Montgomery; Paul Mouncey; Srinivas Murthy; Alistair Nichol; Rachael Parke; Jane Parker; Kathryn Rowan; Ashish Sanil; Marlene Santos; Christina Saunders; Christopher Seymour; Anne Turner; Frank van de Veerdonk; Balasubramanian Venkatesh; Ryan Zarychanski; Scott Berry; Roger J Lewis; Colin McArthur; Steven A Webb; Anthony C Gordon; Farah Al-Beidh; Derek Angus; Djillali Annane; Yaseen Arabi; Wilma van Bentum-Puijk; Scott Berry; Abigail Beane; Zahra Bhimani; Marc Bonten; Charlotte Bradbury; Frank Brunkhorst; Meredith Buxton; Allen Cheng; Menno De Jong; Lennie Derde; Lise Estcourt; Herman Goossens; Anthony Gordon; Cameron Green; Rashan Haniffa; Francois Lamontagne; Patrick Lawler; Edward Litton; John Marshall; Daniel McAuley; Shay McGuinness; Bryan McVerry; Stephanie Montgomery; Paul Mouncey; Srinivas Murthy; Alistair Nichol; Rachael Parke; Kathryn Rowan; Christopher Seymour; Anne Turner; Frank van de Veerdonk; Steve Webb; Ryan Zarychanski; Lewis Campbell; Andrew Forbes; David Gattas; Stephane Heritier; Lisa Higgins; Peter Kruger; Sandra Peake; Jeffrey Presneill; Ian Seppelt; Tony Trapani; Paul Young; Sean Bagshaw; Nick Daneman; Niall Ferguson; Cheryl Misak; Marlene Santos; Sebastiaan Hullegie; Mathias Pletz; Gernot Rohde; Kathy Rowan; Brian Alexander; Kim Basile; Timothy Girard; Christopher Horvat; David Huang; Kelsey Linstrum; Jennifer Vates; Richard Beasley; Robert Fowler; Steve McGloughlin; Susan Morpeth; David Paterson; Bala Venkatesh; Tim Uyeki; Kenneth Baillie; Eamon Duffy; Rob Fowler; Thomas Hills; Katrina Orr; Asad Patanwala; Steve Tong; Mihai Netea; Shilesh Bihari; Marc Carrier; Dean Fergusson; Ewan Goligher; Ghady Haidar; Beverley Hunt; Anand Kumar; Mike Laffan; Patrick Lawless; Sylvain Lother; Peter McCallum; Saskia Middeldopr; Zoe McQuilten; Matthew Neal; John Pasi; Roger Schutgens; Simon Stanworth; Alexis Turgeon; Alexandra Weissman; Neill Adhikari; Matthew Anstey; Emily Brant; Angelique de Man; Francois Lamonagne; Marie-Helene Masse; Andrew Udy; Donald Arnold; Phillipe Begin; Richard Charlewood; Michael Chasse; Mark Coyne; Jamie Cooper; James Daly; Iain Gosbell; Heli Harvala-Simmonds; Tom Hills; Sheila MacLennan; David Menon; John McDyer; Nicole Pridee; David Roberts; Manu Shankar-Hari; Helen Thomas; Alan Tinmouth; Darrell Triulzi; Tim Walsh; Erica Wood; Carolyn Calfee; Cecilia O’Kane; Murali Shyamsundar; Pratik Sinha; Taylor Thompson; Ian Young; Shailesh Bihari; Carol Hodgson; John Laffey; Danny McAuley; Neil Orford; Ary Neto; Michelle Detry; Mark Fitzgerald; Roger Lewis; Anna McGlothlin; Ashish Sanil; Christina Saunders; Lindsay Berry; Elizabeth Lorenzi; Eliza Miller; Vanessa Singh; Claire Zammit; Wilma van Bentum Puijk; Wietske Bouwman; Yara Mangindaan; Lorraine Parker; Svenja Peters; Ilse Rietveld; Kik Raymakers; Radhika Ganpat; Nicole Brillinger; Rene Markgraf; Kate Ainscough; Kathy Brickell; Aisha Anjum; Janis-Best Lane; Alvin Richards-Belle; Michelle Saull; Daisy Wiley; Julian Bion; Jason Connor; Simon Gates; Victoria Manax; Tom van der Poll; John Reynolds; Marloes van Beurden; Evelien Effelaar; Joost Schotsman; Craig Boyd; Cain Harland; Audrey Shearer; Jess Wren; Giles Clermont; William Garrard; Kyle Kalchthaler; Andrew King; Daniel Ricketts; Salim Malakoutis; Oscar Marroquin; Edvin Music; Kevin Quinn; Heidi Cate; Karen Pearson; Joanne Collins; Jane Hanson; Penny Williams; Shane Jackson; Adeeba Asghar; Sarah Dyas; Mihaela Sutu; Sheenagh Murphy; Dawn Williamson; Nhlanhla Mguni; Alison Potter; David Porter; Jayne Goodwin; Clare Rook; Susie Harrison; Hannah Williams; Hilary Campbell; Kaatje Lomme; James Williamson; Jonathan Sheffield; Willian van’t Hoff; Phobe McCracken; Meredith Young; Jasmin Board; Emma Mart; Cameron Knott; Julie Smith; Catherine Boschert; Julia Affleck; Mahesh Ramanan; Ramsy D’Souza; Kelsey Pateman; Arif Shakih; Winston Cheung; Mark Kol; Helen Wong; Asim Shah; Atul Wagh; Joanne Simpson; Graeme Duke; Peter Chan; Brittney Cartner; Stephanie Hunter; Russell Laver; Tapaswi Shrestha; Adrian Regli; Annamaria Pellicano; James McCullough; Mandy Tallott; Nikhil Kumar; Rakshit Panwar; Gail Brinkerhoff; Cassandra Koppen; Federica Cazzola; Matthew Brain; Sarah Mineall; Roy Fischer; Vishwanath Biradar; Natalie Soar; Hayden White; Kristen Estensen; Lynette Morrison; Joanne Smith; Melanie Cooper; Monash Health; Yahya Shehabi; Wisam Al-Bassam; Amanda Hulley; Christina Whitehead; Julie Lowrey; Rebecca Gresha; James Walsham; Jason Meyer; Meg Harward; Ellen Venz; Patricia Williams; Catherine Kurenda; Kirsy Smith; Margaret Smith; Rebecca Garcia; Deborah Barge; Deborah Byrne; Kathleen Byrne; Alana Driscoll; Louise Fortune; Pierre Janin; Elizabeth Yarad; Naomi Hammond; Frances Bass; Angela Ashelford; Sharon Waterson; Steve Wedd; Robert McNamara; Heidi Buhr; Jennifer Coles; Sacha Schweikert; Bradley Wibrow; Rashmi Rauniyar; Erina Myers; Ed Fysh; Ashlish Dawda; Bhaumik Mevavala; Ed Litton; Janet Ferrier; Priya Nair; Hergen Buscher; Claire Reynolds; John Santamaria; Leanne Barbazza; Jennifer Homes; Roger Smith; Lauren Murray; Jane Brailsford; Loretta Forbes; Teena Maguire; Vasanth Mariappa; Judith Smith; Scott Simpson; Matthew Maiden; Allsion Bone; Michelle Horton; Tania Salerno; Martin Sterba; Wenli Geng; Pieter Depuydt; Jan De Waele; Liesbet De Bus; Jan Fierens; Stephanie Bracke; Brenda Reeve; William Dechert; Michaël Chassé; François Martin Carrier; Dounia Boumahni; Fatna Benettaib; Ali Ghamraoui; David Bellemare; Ève Cloutier; Charles Francoeur; François Lamontagne; Frédérick D’Aragon; Elaine Carbonneau; Julie Leblond; Gloria Vazquez-Grande; Nicole Marten; Martin Albert; Karim Serri; Alexandros Cavayas; Mathilde Duplaix; Virginie Williams; Bram Rochwerg; Tim Karachi; Simon Oczkowski; John Centofanti; Tina Millen; Erick Duan; Jennifer Tsang; Lisa Patterson; Shane English; Irene Watpool; Rebecca Porteous; Sydney Miezitis; Lauralyn McIntyre; Laurent Brochard; Karen Burns; Gyan Sandhu; Imrana Khalid; Alexandra Binnie; Elizabeth Powell; Alexandra McMillan; Tracy Luk; Noah Aref; Zdravko Andric; Sabina Cviljevic; Renata Đimoti; Marija Zapalac; Gordan Mirković; Bruno Baršić; Marko Kutleša; Viktor Kotarski; Ana Vujaklija Brajković; Jakša Babel; Helena Sever; Lidija Dragija; Ira Kušan; Suvi Vaara; Leena Pettilä; Jonna Heinonen; Anne Kuitunen; Sari Karlsson; Annukka Vahtera; Heikki Kiiski; Sanna Ristimäki; Amine Azaiz; Cyril Charron; Mathieu Godement; Guillaume Geri; Antoine Vieillard-Baron; Franck Pourcine; Mehran Monchi; David Luis; Romain Mercier; Anne Sagnier; Nathalie Verrier; Cecile Caplin; Shidasp Siami; Christelle Aparicio; Sarah Vautier; Asma Jeblaoui; Muriel Fartoukh; Laura Courtin; Vincent Labbe; Cécile Leparco; Grégoire Muller; Mai-Anh Nay; Toufik Kamel; Dalila Benzekri; Sophie Jacquier; Emmanuelle Mercier; Delphine Chartier; Charlotte Salmon; PierreFrançois Dequin; Francis Schneider; Guillaume Morel; Sylvie L’Hotellier; Julio Badie; Fernando Daniel Berdaguer; Sylvain Malfroy; Chaouki Mezher; Charlotte Bourgoin; Bruno Megarbane; Nicolas Deye; Isabelle Malissin; Laetitia Sutterlin; Christophe Guitton; Cédric Darreau; Mickaël Landais; Nicolas Chudeau; Alain Robert; Pierre Moine; Nicholas Heming; Virginie Maxime; Isabelle Bossard; Tiphaine Barbarin Nicholier; Gwenhael Colin; Vanessa Zinzoni; Natacham Maquigneau; André Finn; Gabriele Kreß; Uwe Hoff; Carl Friedrich Hinrichs; Jens Nee; Mathias Pletz; Stefan Hagel; Juliane Ankert; Steffi Kolanos; Frank Bloos; Sirak Petros; Bastian Pasieka; Kevin Kunz; Peter Appelt; Bianka Schütze; Stefan Kluge; Axel Nierhaus; Dominik Jarczak; Kevin Roedl; Dirk Weismann; Anna Frey; Vivantes Klinikum Neukölln; Lorenz Reill; Michael Distler; Astrid Maselli; János Bélteczki; István Magyar; Ágnes Fazekas; Sándor Kovács; Viktória Szőke; Gábor Szigligeti; János Leszkoven; Daniel Collins; Patrick Breen; Stephen Frohlich; Ruth Whelan; Bairbre McNicholas; Michael Scully; Siobhan Casey; Maeve Kernan; Peter Doran; Michael O’Dywer; Michelle Smyth; Leanne Hayes; Oscar Hoiting; Marco Peters; Els Rengers; Mirjam Evers; Anton Prinssen; Jeroen Bosch Ziekenhuis; Koen Simons; Wim Rozendaal; F Polderman; P de Jager; M Moviat; A Paling; A Salet; Emma Rademaker; Anna Linda Peters; E de Jonge; J Wigbers; E Guilder; M Butler; Keri-Anne Cowdrey; Lynette Newby; Yan Chen; Catherine Simmonds; Rachael McConnochie; Jay Ritzema Carter; Seton Henderson; Kym Van Der Heyden; Jan Mehrtens; Tony Williams; Alex Kazemi; Rima Song; Vivian Lai; Dinu Girijadevi; Robert Everitt; Robert Russell; Danielle Hacking; Ulrike Buehner; Erin Williams; Troy Browne; Kate Grimwade; Jennifer Goodson; Owen Keet; Owen Callender; Robert Martynoga; Kara Trask; Amelia Butler; Livia Schischka; Chelsea Young; Eden Lesona; Shaanti Olatunji; Yvonne Robertson; Nuno José; Teodoro Amaro dos Santos Catorze; Tiago Nuno Alfaro de Lima Pereira; Lucilia Maria Neves Pessoa; Ricardo Manuel Castro Ferreira; Joana Margarida Pereira Sousa Bastos; Simin Aysel Florescu; Delia Stanciu; Miahela Florentina Zaharia; Alma Gabriela Kosa; Daniel Codreanu; Yaseen Marabi; Eman Al Qasim; Mohamned Moneer Hagazy; Lolowa Al Swaidan; Hatim Arishi; Rosana Muñoz-Bermúdez; Judith Marin-Corral; Anna Salazar Degracia; Francisco Parrilla Gómez; Maria Isabel Mateo López; Jorge Rodriguez Fernandez; Sheila Cárcel Fernández; Rosario Carmona Flores; Rafael León López; Carmen de la Fuente Martos; Angela Allan; Petra Polgarova; Neda Farahi; Stephen McWilliam; Daniel Hawcutt; Laura Rad; Laura O’Malley; Jennifer Whitbread; 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Sarah Cornell; Suresh Pillai; Rachel Harford; Tabitha Rees; Helen Ivatt; Ajay Sundara Raman; Miriam Davey; Kelvin Lee; Russell Barber; Manish Chablani; Farooq Brohi; Vijay Jagannathan; Michele Clark; Sarah Purvis; Bill Wetherill; Ahilanandan Dushianthan; Rebecca Cusack; Kim de Courcy-Golder; Simon Smith; Susan Jackson; Ben Attwood; Penny Parsons; Valerie Page; Xiao Bei Zhao; Deepali Oza; Jonathan Rhodes; Tom Anderson; Sheila Morris; Charlotte Xia Le Tai; Amy Thomas; Alexandra Keen; Stephen Digby; Nicholas Cowley; Laura Wild; David Southern; Harsha Reddy; Andy Campbell; Claire Watkins; Sara Smuts; Omar Touma; Nicky Barnes; Peter Alexander; Tim Felton; Susan Ferguson; Katharine Sellers; Joanne Bradley-Potts; David Yates; Isobel Birkinshaw; Kay Kell; Nicola Marshall; Lisa Carr-Knott; Charlotte Summers Journal: JAMA Date: 2020-10-06 Impact factor: 56.272
Authors: Sofia Ramiro; Rémy L M Mostard; César Magro-Checa; Christel M P van Dongen; Tom Dormans; Jacqueline Buijs; Michiel Gronenschild; Martijn D de Kruif; Eric H J van Haren; Tom van Kraaij; Mathie P G Leers; Ralph Peeters; Dennis R Wong; Robert B M Landewé Journal: Ann Rheum Dis Date: 2020-07-20 Impact factor: 19.103
Authors: Mónica Climente-Martí; Oreto Ruiz-Millo; Ian López-Cruz; Ángel Atienza-García; Eva Martínez-Moragón; Emilio Garijo-Gómez; María Luisa López-Grima; Rafael Zaragoza-Crespo; Juan Vicente Llau-Pitarch; Daniel Bautista-Rentero; José Miguel Nogueira-Coito; Tomás Ripollés-González; María Antonia Marco-Artal; Ramón Romero-Serrano; Francisco Dolz-Sinisterra; Rosario López-Estudillo Journal: Int J Clin Pract Date: 2021-06-28 Impact factor: 3.149
Authors: Giuseppe Pannone; Vito Carlo Alberto Caponio; Ilenia Sara De Stefano; Maria Antonietta Ramunno; Mario Meccariello; Alessio Agostinone; Maria Carmela Pedicillo; Giuseppe Troiano; Khrystyna Zhurakivska; Tommaso Cassano; Maria Eleonora Bizzoca; Silvana Papagerakis; Franco Maria Buonaguro; Shailesh Advani; Lorenzo Lo Muzio Journal: Infect Agent Cancer Date: 2021-05-17 Impact factor: 2.965
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