Martijn J H Doeleman1,2, Sytze de Roock3,4, Nathan Buijsse3,4, Mark Klein3, Gouke J Bonsel5,6, Vicki Seyfert-Margolis7, Joost F Swart3,4, Nico M Wulffraat3,4. 1. Department of Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, P.O. Box 85090, 3508, AB, Utrecht, The Netherlands. m.j.h.doeleman@umcutrecht.nl. 2. Faculty of Medicine, Utrecht University, Utrecht, The Netherlands. m.j.h.doeleman@umcutrecht.nl. 3. Department of Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, P.O. Box 85090, 3508, AB, Utrecht, The Netherlands. 4. Faculty of Medicine, Utrecht University, Utrecht, The Netherlands. 5. The EuroQol Research Foundation, Rotterdam, The Netherlands. 6. Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands. 7. MyOwnMed Inc., Bethesda, MD, USA.
Abstract
BACKGROUND: Pediatric patients with juvenile idiopathic arthritis (JIA) are at risk for a lower health-related quality of life compared to their healthy peers. Remote monitoring of health-related quality of life using electronic patient-reported outcomes could provide important information to treating physicians. The aim of this study was to investigate if self-assessment with the EuroQol five-dimensional 'youth' questionnaire with five levels (EQ-5D-Y-5 L) inside a mobile E-health application could identify JIA patients in need of possible treatment adjustments. METHODS: The EQ-5D-Y-5 L was completed via a mobile application (Reuma2Go) between October 2017 and January 2019. The clinical juvenile arthritis disease activity score with 71 joint count (cJADAS-71) was reported at every corresponding visit as reference for disease activity. Previously described cJADAS-71 thresholds were used to identify patients in possible need of treatment adjustments. Discriminatory power of the EQ-5D-Y-5 L was assessed by ROC-curves and diagnostic characteristics. RESULTS: Sixty-eight JIA patients completed the EQ-5D-Y-5 L questionnaire. Median cJADAS-71 indicated low disease activity overall in the studied population. ROC curves and diagnostic characteristics demonstrated that self-assessment with the EQ-5D-Y-5 L could distinguish between patients with inactive disease (or minimal disease activity) and moderate to high disease activity with good accuracy (87%), sensitivity (85%), specificity (89%) and negative predictive value (86%). CONCLUSIONS: Results demonstrate that the EQ-5D-Y-5 L was able to identify JIA patients in need of possible treatment adjustments in our studied population. Remote monitoring of health-related quality of life and patient-reported outcomes via E-health applications could provide important additional information to determine the frequency of clinical visits, assess therapeutic efficacy and guide treat-to-target strategies in pediatric patients with JIA.
BACKGROUND: Pediatric patients with juvenile idiopathic arthritis (JIA) are at risk for a lower health-related quality of life compared to their healthy peers. Remote monitoring of health-related quality of life using electronic patient-reported outcomes could provide important information to treating physicians. The aim of this study was to investigate if self-assessment with the EuroQol five-dimensional 'youth' questionnaire with five levels (EQ-5D-Y-5 L) inside a mobile E-health application could identify JIA patients in need of possible treatment adjustments. METHODS: The EQ-5D-Y-5 L was completed via a mobile application (Reuma2Go) between October 2017 and January 2019. The clinical juvenile arthritis disease activity score with 71 joint count (cJADAS-71) was reported at every corresponding visit as reference for disease activity. Previously described cJADAS-71 thresholds were used to identify patients in possible need of treatment adjustments. Discriminatory power of the EQ-5D-Y-5 L was assessed by ROC-curves and diagnostic characteristics. RESULTS: Sixty-eight JIA patients completed the EQ-5D-Y-5 L questionnaire. Median cJADAS-71 indicated low disease activity overall in the studied population. ROC curves and diagnostic characteristics demonstrated that self-assessment with the EQ-5D-Y-5 L could distinguish between patients with inactive disease (or minimal disease activity) and moderate to high disease activity with good accuracy (87%), sensitivity (85%), specificity (89%) and negative predictive value (86%). CONCLUSIONS: Results demonstrate that the EQ-5D-Y-5 L was able to identify JIA patients in need of possible treatment adjustments in our studied population. Remote monitoring of health-related quality of life and patient-reported outcomes via E-health applications could provide important additional information to determine the frequency of clinical visits, assess therapeutic efficacy and guide treat-to-target strategies in pediatric patients with JIA.
Entities:
Keywords:
Disease activity; E-health; EQ-5D-Y-5 L; Health-related quality of life; Juvenile idiopathic arthritis; Mobile applications; Remote monitoring
Authors: Anita Tollisen; Anne M Selvaag; Hanne A Aulie; Vibke Lilleby; Astrid Aasland; Anners Lerdal; Berit Flatø Journal: Arthritis Care Res (Hoboken) Date: 2018-03-07 Impact factor: 4.794
Authors: L Haverman; M A Grootenhuis; J M van den Berg; M van Veenendaal; K M Dolman; J F Swart; T W Kuijpers; M A J van Rossum Journal: Arthritis Care Res (Hoboken) Date: 2012-05 Impact factor: 4.794
Authors: M G Sawyer; J N Whitham; D M Roberton; J E Taplin; J W Varni; P A Baghurst Journal: Rheumatology (Oxford) Date: 2003-10-17 Impact factor: 7.580
Authors: Ellen Nordal; Veronika Rypdal; Ellen Dalen Arnstad; Kristiina Aalto; Lillemor Berntson; Maria Ekelund; Anders Fasth; Mia Glerup; Troels Herlin; Susan Nielsen; Suvi Peltoniemi; Marek Zak; Nils Thomas Songstad; Marite Rygg Journal: Pediatr Rheumatol Online J Date: 2019-07-15 Impact factor: 3.054
Authors: Luiza R Grazziotin; Gillian Currie; Marinka Twilt; Maarten J IJzerman; Michelle M A Kip; Hendrik Koffijberg; Gouke Bonsel; Susanne M Benseler; Joost F Swart; Sebastiaan J Vastert; Nico M Wulffraat; Rae S M Yeung; Wineke Armbrust; J Merlijn van den Berg; Deborah A Marshall Journal: Pediatr Rheumatol Online J Date: 2022-07-23 Impact factor: 3.413
Authors: Sonia Butler; Dean Sculley; Derek Santos; Antoni Fellas; Xavier Gironès; Davinder Singh-Grewal; Andrea Coda Journal: J Med Internet Res Date: 2022-02-02 Impact factor: 5.428