| Literature DB >> 33750783 |
Shixiong Hu1, Wei Wang2, Yan Wang2, Maria Litvinova3,4, Kaiwei Luo1, Lingshuang Ren2, Qianlai Sun1, Xinghui Chen2, Ge Zeng1, Jing Li2, Lu Liang5, Zhihong Deng1, Wen Zheng2, Mei Li2, Hao Yang1, Jinxin Guo2, Kai Wang2, Xinhua Chen2, Ziyan Liu1, Han Yan2, Huilin Shi2, Zhiyuan Chen2, Yonghong Zhou2, Kaiyuan Sun6, Alessandro Vespignani4,7, Cécile Viboud6, Lidong Gao8, Marco Ajelli9,10, Hongjie Yu11,12,13,14.
Abstract
Several mechanisms driving SARS-CoV-2 transmission remain unclear. Based on individual records of 1178 potential SARS-CoV-2 infectors and their 15,648 contacts in Hunan, China, we estimated key transmission parameters. The mean generation time was estimated to be 5.7 (median: 5.5, IQR: 4.5, 6.8) days, with infectiousness peaking 1.8 days before symptom onset, with 95% of transmission events occurring between 8.8 days before and 9.5 days after symptom onset. Most transmission events occurred during the pre-symptomatic phase (59.2%). SARS-CoV-2 susceptibility to infection increases with age, while transmissibility is not significantly different between age groups and between symptomatic and asymptomatic individuals. Contacts in households and exposure to first-generation cases are associated with higher odds of transmission. Our findings support the hypothesis that children can effectively transmit SARS-CoV-2 and highlight how pre-symptomatic and asymptomatic transmission can hinder control efforts.Entities:
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Year: 2021 PMID： 33750783 PMCID： PMC7943579 DOI： 10.1038/s41467-021-21710-6
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919