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Literature DB >> 3375058

The YYRR box: a conserved dipyrimidine-dipurine sequence element in Drosophila and other eukaryotes.

D Cavener¹, Y Feng, B Foster, P Krasney, M Murtha, C Schonbaum, X Xiao.

Abstract

We have discovered a novel DNA sequence element in Drosophila which is based upon a CTGA tandem repeat. This element has been named the YYRR box to emphasize its dipyrimidine-dipurine nature which is predicted to have unusual structural features. Southern hybridization analysis of genomic DNA indicates the presence of 25-30 copies of the YYRR box in each of three Drosophila species (melanogaster, pseudoobscura, and virilis) and conservation of genomic location within species. Similar analysis of human and rat DNA indicates the presence of YYRR related sequences in mammals as well. YYRR boxes have been localized to two genetic loci in Drosophila: Gld and a gene tentative identified as ted. These two genes exhibit correlated patterns of developmental expression and an identical mutant phenotype. Sequence analysis of the Gld YYRR box in three Drosophila species revealed a high degree of conservation despite its intronic location.

Entities: Chemical Gene Species

Mesh：

Year: 1988 PMID： 3375058 PMCID： PMC336500 DOI： 10.1093/nar/16.8.3375

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

22 in total

1. Molecular Genetics of the Bithorax Complex in Drosophila melanogaster.

Authors: W Bender; M Akam; F Karch; P A Beachy; M Peifer; P Spierer; E B Lewis; D S Hogness
Journal: Science Date: 1983-07-01 Impact factor: 47.728

2. Interspecific nucleotide sequence comparisons used to identify regulatory and structural features of the Drosophila hsp82 gene.

Authors: R K Blackman; M Meselson
Journal: J Mol Biol Date: 1986-04-20 Impact factor: 5.469

3. opa: a novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster.

Authors: K A Wharton; B Yedvobnick; V G Finnerty; S Artavanis-Tsakonas
Journal: Cell Date: 1985-01 Impact factor: 41.582

Review 1. Potential genetic functions of tandem repeated DNA sequence blocks in the human genome are based on a highly conserved "chromatin folding code".

Authors: P Vogt
Journal: Hum Genet Date: 1990-03 Impact factor: 4.132

2. Molecular structure and transformation of the glucose dehydrogenase gene in Drosophila melanogaster.

Authors: R Whetten; E Organ; P Krasney; D Cox-Foster; D Cavener
Journal: Genetics Date: 1988-10 Impact factor: 4.562

2 in total

The YYRR box: a conserved dipyrimidine-dipurine sequence element in Drosophila and other eukaryotes.

1. Molecular Genetics of the Bithorax Complex in Drosophila melanogaster.

2. Interspecific nucleotide sequence comparisons used to identify regulatory and structural features of the Drosophila hsp82 gene.

3. opa: a novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster.

4. A common structural feature in promoter sequences of E. coli.

5. The abdominal region of the bithorax complex.

6. Structural features are as important as sequence homologies in Drosophila heat shock gene upstream regions.

7. Patterns of DNA structural polymorphism and their evolutionary implications.

8. Immunoglobulin class switching.

9. Reversible bending and helix geometry in a B-DNA dodecamer: CGCGAATTBrCGCG.

10. DNA sequencing with chain-terminating inhibitors.

Review 1. Potential genetic functions of tandem repeated DNA sequence blocks in the human genome are based on a highly conserved "chromatin folding code".

2. Molecular structure and transformation of the glucose dehydrogenase gene in Drosophila melanogaster.