| Literature DB >> 33746453 |
Dibya L Praharaj1, Bipadabhanjan Mallick1, Preetam Nath1, Sarat C Panigrahi1, Prasanta Padhan2, Nageswar Sahu3.
Abstract
Hepatic involvement in systemic lupus erythematosus (SLE) is common but described infrequently. Liver is usually never the primary organ to be affected in lupus. Again hepatic involvement probably does not carry much prognostic importance though it may correlate with lupus activity. We here report a case of 21-year-old man with no prior comorbidity or addiction who presented to us with acute hepatic illness with jaundice. He also had malar rash and arthralgia. Viral markers were negative. Antinuclear antibody and anti-double-stranded DNA (dsDNA) were strongly positive. Liver biopsy was consistent with autoimmune hepatitis, whereas skin biopsy was suggestive of SLE. He had a brisk and complete recovery with prompt use of immunosuppressive agents (corticosteroids and azathioprine). Cyclophosphamide was started latter in view of lupus nephritis. This is probably the fourth reported case of SLE presenting as acute hepatic illness with jaundice.Entities:
Keywords: ACR, American College of Rheumatology; AIH, Autoimmune Hepatitis; ALP, Alkaline Phosphatase; ALT, Alanine Transaminase; ANA, Antinuclear Antibody; AST, Aspartate Transaminase; DILI, Drug-induced Liver Injury; HAV, Hepatitis A Virus; HEV, Hepatitis E Virus; MRCP, Magnetic Resonance Cholangiopancreatography; PBC, Primary Biliary Cholangitis; PSC, Primary Sclerosing Cholangitis; SLE, Systemic Lupus Erythematosus; TLC, Total Leucocyte Count; acute hepatitis; ds DNA, Double-stranded DNA; immunosuppressive agents; lupus hepatitis; lupus nephritis; systemic lupus erythematous
Year: 2020 PMID： 33746453 PMCID： PMC7953008 DOI： 10.1016/j.jceh.2020.05.009
Source DB: PubMed Journal: J Clin Exp Hepatol ISSN： 0973-6883