Literature DB >> 33743809

TOX as a potential target for immunotherapy in lymphocytic malignancies.

Chaofeng Liang1,2, Shuxin Huang1, Yujie Zhao1, Shaohua Chen3, Yangqiu Li4.   

Abstract

TOX (thymocyte selection-associated HMG BOX) is a member of a family of transcriptional factors that contain the highly conserved high mobility group box (HMG-box) region. Increasing studies have shown that TOX is involved in maintaining tumors and promoting T cell exhaustion. In this review, we summarized the biological functions of TOX and its contribution as related to lymphocytic malignancies. We also discussed the potential role of TOX as an immune biomarker and target in immunotherapy for hematological malignancies.

Entities:  

Keywords:  Biological function; Immune biomarker; Immunotherapy; Lymphocytic malignancies; T cell exhaustion; Thymocyte selection-associated HMG BOX

Year:  2021        PMID： 33743809      PMCID： PMC7981945          DOI： 10.1186/s40364-021-00275-y

Source DB:  PubMed          Journal:  Biomark Res        ISSN： 2050-7771


  47 in total

1.  The role of the tumor suppressor RUNX3 in giant cell tumor of the bone.

Authors:  Ya-Xin Han; De-Yong Liang
Journal:  Int J Oncol       Date:  2011-11-04       Impact factor: 5.650

Review 2.  The many roles of TOX in the immune system.

Authors:  Parinaz Aliahmad; Akop Seksenyan; Jonathan Kaye
Journal:  Curr Opin Immunol       Date:  2011-12-30       Impact factor: 7.486

3.  TOX2 regulates human natural killer cell development by controlling T-BET expression.

Authors:  Queenie P Vong; Wai-Hang Leung; Jim Houston; Ying Li; Barbara Rooney; Martha Holladay; Robert A J Oostendorp; Wing Leung
Journal:  Blood       Date:  2014-10-28       Impact factor: 22.113

4.  TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia.

Authors:  Riadh Lobbardi; Jordan Pinder; Barbara Martinez-Pastor; Marina Theodorou; Jessica S Blackburn; Brian J Abraham; Yuka Namiki; Marc Mansour; Nouran S Abdelfattah; Aleksey Molodtsov; Gabriela Alexe; Debra Toiber; Manon de Waard; Esha Jain; Myriam Boukhali; Mattia Lion; Deepak Bhere; Khalid Shah; Alejandro Gutierrez; Kimberly Stegmaier; Lewis B Silverman; Ruslan I Sadreyev; John M Asara; Marjorie A Oettinger; Wilhelm Haas; A Thomas Look; Richard A Young; Raul Mostoslavsky; Graham Dellaire; David M Langenau
Journal:  Cancer Discov       Date:  2017-10-03       Impact factor: 39.397

5.  TOX3 regulates calcium-dependent transcription in neurons.

Authors:  Shauna H Yuan; Zilong Qiu; Anirvan Ghosh
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-05       Impact factor: 11.205

Review 6.  Role, function and regulation of the thymocyte selection-associated high mobility group box protein in CD8+ T cell exhaustion.

Authors:  Yanmin Cheng; Zhaozhao Shao; Li Chen; Qiaoyu Zheng; Qiqi Zhang; Wenjie Ding; Meng Zhang; Qiongfang Yu; Dian Gao
Journal:  Immunol Lett       Date:  2020-11-11       Impact factor: 3.685

7.  TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion.

Authors:  Hyungseok Seo; Joyce Chen; Edahí González-Avalos; Daniela Samaniego-Castruita; Arundhoti Das; Yueqiang H Wang; Isaac F López-Moyado; Romain O Georges; Wade Zhang; Atsushi Onodera; Cheng-Jang Wu; Li-Fan Lu; Patrick G Hogan; Avinash Bhandoola; Anjana Rao
Journal:  Proc Natl Acad Sci U S A       Date:  2019-05-31       Impact factor: 12.779

8.  Genetic and Epigenetic Regulation of TOX3 Expression in Breast Cancer.

Authors:  Yoo-Jeong Han; Jing Zhang; Yonglan Zheng; Dezheng Huo; Olufunmilayo I Olopade
Journal:  PLoS One       Date:  2016-11-02       Impact factor: 3.240

9.  TOX3 is a favorable prognostic indicator and potential immunomodulatory factor in lung adenocarcinoma.

Authors:  Haoyu Lin; Jianxiong Cui; Weiquan Liang
Journal:  Oncol Lett       Date:  2019-08-16       Impact factor: 2.967

10.  IL-1α Gene Deletion Protects Oligodendrocytes after Spinal Cord Injury through Upregulation of the Survival Factor Tox3.

Authors:  Dominic Bastien; Victor Bellver Landete; Martine Lessard; Nicolas Vallières; Mathieu Champagne; Akira Takashima; Marie-Ève Tremblay; Yannick Doyon; Steve Lacroix
Journal:  J Neurosci       Date:  2015-07-29       Impact factor: 6.167
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  10 in total

1.  Immune checkpoint receptor VISTA on immune cells is associated with expression of T-cell exhaustion marker TOX and worse prognosis in renal cell carcinoma with venous tumor thrombus.

Authors:  Łukasz Zapała; Michał Kunc; Sumit Sharma; Rafał Pęksa; Marta Popęda; Wojciech Biernat; Piotr Radziszewski
Journal:  J Cancer Res Clin Oncol       Date:  2022-08-30       Impact factor: 4.322

Review 2.  TCF-1: a maverick in T cell development and function.

Authors:  Fotini Gounari; Khashayarsha Khazaie
Journal:  Nat Immunol       Date:  2022-04-29       Impact factor: 31.250

3.  Increased TOX expression associates with exhausted T cells in patients with multiple myeloma.

Authors:  Yujie Zhao; Pengjun Liao; Shuxin Huang; Tairan Deng; Jiaxiong Tan; Youxue Huang; Huien Zhan; Yangqiu Li; Shaohua Chen; Liye Zhong
Journal:  Exp Hematol Oncol       Date:  2022-03-04

4.  Risk Association of TOX3 and MMP7 Gene Polymorphisms with Sporadic Breast Cancer in Mexican Women.

Authors:  Orlando Solis-Coronado; Mónica Patricia Villarreal-Vela; Hazyadee Frecia Rodríguez-Gutiérrez; Juan Francisco González-Guerrero; Ricardo M Cerda-Flores; Fernando Alcorta-Núñez; Karen Paola Camarillo-Cárdenas; Diana Cristina Pérez-Ibave; Oscar Vidal-Gutiérrez; Genaro A Ramírez-Correa; María Lourdes Garza-Rodríguez
Journal:  Curr Oncol       Date:  2022-02-11       Impact factor: 3.677

Review 5.  Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing.

Authors:  Alexander Dimitri; Friederike Herbst; Joseph A Fraietta
Journal:  Mol Cancer       Date:  2022-03-18       Impact factor: 27.401

Review 6.  Targeting macrophages in hematological malignancies: recent advances and future directions.

Authors:  Wei Li; Fang Wang; Rongqun Guo; Zhilei Bian; Yongping Song
Journal:  J Hematol Oncol       Date:  2022-08-17       Impact factor: 23.168

7.  BET bromodomain inhibition rescues PD-1-mediated T-cell exhaustion in acute myeloid leukemia.

Authors:  Mengjun Zhong; Rili Gao; Ruocong Zhao; Youxue Huang; Cunte Chen; Kehan Li; Xibao Yu; Dingrui Nie; Zheng Chen; Xin Liu; Zhuandi Liu; Shaohua Chen; Yuhong Lu; Zhi Yu; Liang Wang; Peng Li; Chengwu Zeng; Yangqiu Li
Journal:  Cell Death Dis       Date:  2022-08-02       Impact factor: 9.685

8.  Susac Syndrome With Livedo Reticularis: Pathogenesis and Literature Review.

Authors:  Bahadar S Srichawla
Journal:  Cureus       Date:  2022-07-27

9.  Immunohistochemical Expression Patterns of CD45RO, p105/p50, JAK3, TOX, and IL-17 in Early-Stage Mycosis Fungoides.

Authors:  Tariq N Aladily; Tasnim Abushunar; Ahmad Alhesa; Raneen Alrawi; Noor Almaani; Maram Abdaljaleel
Journal:  Diagnostics (Basel)       Date:  2022-01-17

10.  CD4+ T cells in classical Hodgkin lymphoma express exhaustion associated transcription factors TOX and TOX2: Characterizing CD4+ T cells in Hodgkin lymphoma.

Authors:  Johanna Veldman; Jessica Rodrigues Plaça; Lauren Chong; Miente Martijn Terpstra; Mirjam Mastik; Léon C van Kempen; Klaas Kok; Tomohiro Aoki; Christian Steidl; Anke van den Berg; Lydia Visser; Arjan Diepstra
Journal:  Oncoimmunology       Date:  2022-01-27       Impact factor: 8.110
  10 in total

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