Literature DB >> 19196971

TOX3 regulates calcium-dependent transcription in neurons.

Shauna H Yuan1, Zilong Qiu, Anirvan Ghosh.   

Abstract

We report the cloning and characterization of TOX3, a high mobility group box protein involved in mediating calcium-dependent transcription. TOX3 was identified as a calcium-dependent transactivator using the Transactivator Trap screen. We find that TOX3 interacts with both cAMP response element (CRE)-binding protein (CREB) and CREB-binding protein (CBP), and knockdown of the endogenous TOX3 by RNAi leads to significant reduction of calcium-induced c-fos expression and complete inhibition of calcium activation of the c-fos promoter. The effects of TOX3 on calcium-dependent transcription require the CRE elements. These observations identify TOX3 as an important regulator of calcium-dependent transcription and suggest that TOX3 exerts its effect on CRE-mediated transcription via its association with the CREB-CBP complex.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19196971      PMCID： PMC2650364          DOI： 10.1073/pnas.0805555106

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  23 in total

1.  cDNAs with long CAG trinucleotide repeats from human brain.

Authors:  R L Margolis; M R Abraham; S B Gatchell; S H Li; A S Kidwai; T S Breschel; O C Stine; C Callahan; M G McInnis; C A Ross
Journal:  Hum Genet       Date:  1997-07       Impact factor: 4.132

2.  CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases.

Authors:  M Sheng; M A Thompson; M E Greenberg
Journal:  Science       Date:  1991-06-07       Impact factor: 47.728

3.  Regulation of dendritic growth and remodeling by Rho, Rac, and Cdc42.

Authors:  R Threadgill; K Bobb; A Ghosh
Journal:  Neuron       Date:  1997-09       Impact factor: 17.173

4.  Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133.

Authors:  G A Gonzalez; M R Montminy
Journal:  Cell       Date:  1989-11-17       Impact factor: 41.582

5.  Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock.

Authors:  D D Ginty; J M Kornhauser; M A Thompson; H Bading; K E Mayo; J S Takahashi; M E Greenberg
Journal:  Science       Date:  1993-04-09       Impact factor: 47.728

6.  CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV.

Authors:  S Chawla; G E Hardingham; D R Quinn; H Bading
Journal:  Science       Date:  1998-09-04       Impact factor: 47.728

7.  Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB.

Authors:  D D Ginty; A Bonni; M E Greenberg
Journal:  Cell       Date:  1994-06-03       Impact factor: 41.582

8.  Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene.

Authors:  M R Montminy; L M Bilezikjian
Journal:  Nature       Date:  1987 Jul 9-15       Impact factor: 49.962

9.  Phosphorylated CREB binds specifically to the nuclear protein CBP.

Authors:  J C Chrivia; R P Kwok; N Lamb; M Hagiwara; M R Montminy; R H Goodman
Journal:  Nature       Date:  1993-10-28       Impact factor: 49.962

10.  Activation of the HIV-1 enhancer by the LEF-1 HMG protein on nucleosome-assembled DNA in vitro.

Authors:  P L Sheridan; C T Sheline; K Cannon; M L Voz; M J Pazin; J T Kadonaga; K A Jones
Journal:  Genes Dev       Date:  1995-09-01       Impact factor: 11.361
View more
  35 in total

1.  Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program.

Authors:  Joris van Arensbergen; Javier García-Hurtado; Ignasi Moran; Miguel Angel Maestro; Xiaobo Xu; Mark Van de Casteele; Anouchka L Skoudy; Matteo Palassini; Harry Heimberg; Jorge Ferrer
Journal:  Genome Res       Date:  2010-04-15       Impact factor: 9.043

2.  Fine scale mapping of the breast cancer 16q12 locus.

Authors:  Miriam S Udler; Shahana Ahmed; Catherine S Healey; Kerstin Meyer; Jeffrey Struewing; Melanie Maranian; Erika M Kwon; Jinghui Zhang; Jonathan Tyrer; Eric Karlins; Radka Platte; Bolot Kalmyrzaev; Ed Dicks; Helen Field; Ana-Teresa Maia; Radhika Prathalingam; Andrew Teschendorff; Stewart McArthur; David R Doody; Robert Luben; Carlos Caldas; Leslie Bernstein; Laurence K Kolonel; Brian E Henderson; Anna H Wu; Loic Le Marchand; Giske Ursin; Michael F Press; Annika Lindblom; Sara Margolin; Chen-Yang Shen; Show-Lin Yang; Chia-Ni Hsiung; Daehee Kang; Keun-Young Yoo; Dong-Young Noh; Sei-Hyun Ahn; Kathleen E Malone; Christopher A Haiman; Paul D Pharoah; Bruce A J Ponder; Elaine A Ostrander; Douglas F Easton; Alison M Dunning
Journal:  Hum Mol Genet       Date:  2010-03-23       Impact factor: 6.150

3.  HIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs.

Authors:  J Robert Chang; Ruma Mukerjee; Asen Bagashev; Luis Del Valle; Tinatin Chabrashvili; Brian J Hawkins; Johnny J He; Bassel E Sawaya
Journal:  J Biol Chem       Date:  2011-09-28       Impact factor: 5.157

4.  TOX3 Variants Are Involved in Restless Legs Syndrome and Parkinson's Disease with Opposite Effects.

Authors:  Sadaf Mohtashami; Qin He; Jennifer A Ruskey; Sirui Zhou; Patrick A Dion; Richard P Allen; Christopher J Earley; Edward A Fon; Lan Xiong; Nicolas Dupre; Yves Dauvilliers; Guy A Rouleau; Ziv Gan-Or
Journal:  J Mol Neurosci       Date:  2018-02-05       Impact factor: 3.444

5.  Decellularized porcine brain matrix for cell culture and tissue engineering scaffolds.

Authors:  Jessica A DeQuach; Shauna H Yuan; Lawrence S B Goldstein; Karen L Christman
Journal:  Tissue Eng Part A       Date:  2011-10-17       Impact factor: 3.845

6.  Significant association of TOX3/LOC643714 locus-rs3803662 and breast cancer risk in a cohort of Iranian population.

Authors:  Amir Tajbakhsh; Fahimeh Afzal Javan; Mahdi Rivandi; Atefeh Moezzi; Soheila Abedini; Mahla Asghari; Zahra Farjami; Hosein Soltanian; Fatemeh Homaei Shandiz; Mohammad Mahdi Kooshyar; Alireza Pasdar
Journal:  Mol Biol Rep       Date:  2018-12-04       Impact factor: 2.316

7.  Replication of breast cancer GWAS susceptibility loci in the Women's Health Initiative African American SHARe Study.

Authors:  Carolyn M Hutter; Alicia M Young; Heather M Ochs-Balcom; Cara L Carty; Tao Wang; Christina T L Chen; Thomas E Rohan; Charles Kooperberg; Ulrike Peters
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2011-07-27       Impact factor: 4.254

8.  An in silico approach to characterize nonsynonymous SNPs and regulatory SNPs in human TOX3 gene.

Authors:  Mehran Akhtar; Tazkira Jamal; Jalal Ud Din; Chandni Hayat; Mamoona Rauf; Syed Manzoor Ul Haq; Raham Sher Khan; Aftab Ali Shah; Muhsin Jamal; Fazal Jalil
Journal:  J Genet       Date:  2019-12       Impact factor: 1.166

9.  Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease.

Authors:  Jennifer L Wacker; Shao-Yi Huang; Andrew D Steele; Rebecca Aron; Gregor P Lotz; QuangVu Nguyen; Flaviano Giorgini; Erik D Roberson; Susan Lindquist; Eliezer Masliah; Paul J Muchowski
Journal:  J Neurosci       Date:  2009-07-15       Impact factor: 6.167

10.  Autocrine activation of neuronal NMDA receptors by aspartate mediates dopamine- and cAMP-induced CREB-dependent gene transcription.

Authors:  Luis E F Almeida; Peter D Murray; H Ronald Zielke; Clinton D Roby; Tami J Kingsbury; Bruce K Krueger
Journal:  J Neurosci       Date:  2009-10-07       Impact factor: 6.167
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.