| Literature DB >> 33737394 |
Lorenzo Rella1, Euclides E Fernandes Póvoa1, Jonas Mars1, Annabel L P Ebbing1, Luc Schoppink1, Marco C Betist1, Hendrik C Korswagen2,3.
Abstract
Members of the Wnt family of secreted glycoproteins regulate cell migration through distinct canonical and noncanonical signaling pathways. Studies of vertebrate development and disease have shown that these pathways can have opposing effects on cell migration, but the mechanism of this functional interplay is not known. In the nematode Caenorhabditis elegans, a switch from noncanonical to canonical Wnt signaling terminates the long-range migration of the QR neuroblast descendants, providing a tractable system to study this mechanism in vivo. Here, we show that noncanonical Wnt signaling acts through PIX-1/RhoGEF, while canonical signaling directly activates the Slt-Robo pathway component EVA-1/EVA1C and the Rho GTPase-activating protein RGA-9b/ARHGAP, which are required for migration inhibition. Our results support a model in which cross-talk between noncanonical and canonical Wnt signaling occurs through antagonistic regulation of the Rho GTPases that drive cell migration.Entities:
Keywords: C. elegans; Slt-Robo; Wnt; cell migration; pathway interactions
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Year: 2021 PMID： 33737394 PMCID： PMC8000201 DOI： 10.1073/pnas.2013239118
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 12.779