Literature DB >> 33728599

GABAB Receptors in Neurodegeneration.

Alessandra P Princivalle1.   

Abstract

GABA is the main inhibitory neurotransmitter in the mammalian central nervous system (CNS) and acts via metabotropic GABAB receptors. Neurodegenerative diseases are a major burden and affect an ever increasing number of humans. The actual therapeutic drugs available are partially effective to slow down the progression of the diseases, but there is a clear need to improve pharmacological treatment thus find alternative drug targets and develop newer pharmaco-treatments. This chapter is dedicated to reviewing the latest evidence about GABAB receptors and their inhibitory mechanisms and pathways involved in the neurodegenerative pathologies.
© 2021. Springer Nature Switzerland AG.

Entities:  

Keywords:  Alzheimer’s disease; GABAB receptors; Hippocampal sclerosis; Neurodegenerative diseases; Parkinson’s disease; Temporal lobe epilepsy

Mesh：

Substances：

Year:  2022        PMID： 33728599     DOI： 10.1007/7854_2021_222

Source DB:  PubMed          Journal:  Curr Top Behav Neurosci        ISSN： 1866-3370


  136 in total

1.  Expression of GABA(B1) and GABA(B2) mRNA in the human brain.

Authors:  A Berthele; S Platzer; S Weis; B Conrad; T R Tölle
Journal:  Neuroreport       Date:  2001-10-29       Impact factor: 1.837

2.  Staging of brain pathology related to sporadic Parkinson's disease.

Authors:  Heiko Braak; Kelly Del Tredici; Udo Rüb; Rob A I de Vos; Ernst N H Jansen Steur; Eva Braak
Journal:  Neurobiol Aging       Date:  2003 Mar-Apr       Impact factor: 4.673

3.  GABA(B) receptor autoradiography in hippocampal sclerosis associated with human temporal lobe epilepsy.

Authors:  A Billinton; V H Baird; M Thom; J S Duncan; N Upton; N G Bowery
Journal:  Br J Pharmacol       Date:  2001-01       Impact factor: 8.739

4.  (-)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor.

Authors:  N G Bowery; D R Hill; A L Hudson; A Doble; D N Middlemiss; J Shaw; M Turnbull
Journal:  Nature       Date:  1980-01-03       Impact factor: 49.962

5.  Uncoupling of gamma-aminobutyric acid B receptors from GTP-binding proteins by N-ethylmaleimide: effect of N-ethylmaleimide on purified GTP-binding proteins.

Authors:  T Asano; N Ogasawara
Journal:  Mol Pharmacol       Date:  1986-03       Impact factor: 4.436

6.  gamma-aminobutyric acid type B receptor splice variant proteins GBR1a and GBR1b are both associated with GBR2 in situ and display differential regional and subcellular distribution.

Authors:  D Benke; M Honer; C Michel; B Bettler; H Mohler
Journal:  J Biol Chem       Date:  1999-09-17       Impact factor: 5.157

7.  Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice.

Authors:  Anders Borgkvist; Elizabeth M Avegno; Minerva Y Wong; Mazen A Kheirbek; Mark S Sonders; Rene Hen; David Sulzer
Journal:  Neuron       Date:  2015-09-02       Impact factor: 17.173

8.  Epileptogenesis reduces the sensitivity of presynaptic gamma-aminobutyric acidB receptors on glutamatergic afferents in the amygdala.

Authors:  E K Asprodini; D G Rainnie; P Shinnick-Gallagher
Journal:  J Pharmacol Exp Ther       Date:  1992-09       Impact factor: 4.030

9.  Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model.

Authors:  E H Buhl; T S Otis; I Mody
Journal:  Science       Date:  1996-01-19       Impact factor: 47.728

10.  A G protein couples serotonin and GABAB receptors to the same channels in hippocampus.

Authors:  R Andrade; R C Malenka; R A Nicoll
Journal:  Science       Date:  1986-12-05       Impact factor: 47.728
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