Literature DB >> 26335644

Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice.

Anders Borgkvist1, Elizabeth M Avegno2, Minerva Y Wong2, Mazen A Kheirbek3, Mark S Sonders4, Rene Hen5, David Sulzer6.   

Abstract

Degeneration of dopamine (DA) neurons in Parkinson's disease (PD) causes hypokinesia, but DA replacement therapy can elicit exaggerated voluntary and involuntary behaviors that have been attributed to enhanced DA receptor sensitivity in striatal projection neurons. Here we reveal that in hemiparkinsonian mice, striatal D1 receptor-expressing medium spiny neurons (MSNs) directly projecting to the substantia nigra reticulata (SNr) lose tonic presynaptic inhibition by GABAB receptors. The absence of presynaptic GABAB response potentiates evoked GABA release from MSN efferents to the SNr and drives motor sensitization. This alternative mechanism of sensitization suggests a synaptic target for PD pharmacotherapy.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 26335644      PMCID： PMC4559856          DOI： 10.1016/j.neuron.2015.08.022

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  61 in total

1.  Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry.

Authors:  Alexxai V Kravitz; Benjamin S Freeze; Philip R L Parker; Kenneth Kay; Myo T Thwin; Karl Deisseroth; Anatol C Kreitzer
Journal:  Nature       Date:  2010-07-07       Impact factor: 49.962

2.  Distinct roles of synaptic transmission in direct and indirect striatal pathways to reward and aversive behavior.

Authors:  Takatoshi Hikida; Kensuke Kimura; Norio Wada; Kazuo Funabiki; Shigetada Nakanishi
Journal:  Neuron       Date:  2010-06-24       Impact factor: 17.173

Review 3.  Short-term synaptic plasticity.

Authors:  Robert S Zucker; Wade G Regehr
Journal:  Annu Rev Physiol       Date:  2002       Impact factor: 19.318

4.  Optical induction of synaptic plasticity using a light-sensitive channel.

Authors:  Yan-Ping Zhang; Thomas G Oertner
Journal:  Nat Methods       Date:  2006-12-31       Impact factor: 28.547

5.  Dopamine modulates release from corticostriatal terminals.

Authors:  Nigel S Bamford; Siobhan Robinson; Richard D Palmiter; John A Joyce; Cynthia Moore; Charles K Meshul
Journal:  J Neurosci       Date:  2004-10-27       Impact factor: 6.167

6.  Levodopa-induced dyskinesias in tyrosine hydroxylase deficiency.

Authors:  Roser Pons; Dimitris Syrengelas; Sotiris Youroukos; Irene Orfanou; Arqirios Dinopoulos; Bru Cormand; Aida Ormazabal; Angels Garzía-Cazorla; Mercedes Serrano; Rafael Artuch
Journal:  Mov Disord       Date:  2013-02-06       Impact factor: 10.338

7.  Synaptic organization of GABAergic inputs from the striatum and the globus pallidus onto neurons in the substantia nigra and retrorubral field which project to the medullary reticular formation.

Authors:  M von Krosigk; Y Smith; J P Bolam; A D Smith
Journal:  Neuroscience       Date:  1992-10       Impact factor: 3.590

8.  Recurrent collateral connections of striatal medium spiny neurons are disrupted in models of Parkinson's disease.

Authors:  Stefano Taverna; Ema Ilijic; D James Surmeier
Journal:  J Neurosci       Date:  2008-05-21       Impact factor: 6.167

9.  Cannabinoids inhibit striatonigral GABAergic neurotransmission in the mouse.

Authors:  I Wallmichrath; B Szabo
Journal:  Neuroscience       Date:  2002       Impact factor: 3.590

10.  Phosphodiesterase 10A controls D1-mediated facilitation of GABA release from striato-nigral projections under normal and dopamine-depleted conditions.

Authors:  Dalila Mango; Alessandra Bonito-Oliva; Ada Ledonne; Robert Nisticò; Valentina Castelli; Mauro Giorgi; Giuseppe Sancesario; Gilberto Fisone; Nicola Berretta; Nicola Biagio Mercuri
Journal:  Neuropharmacology       Date:  2013-08-22       Impact factor: 5.250
View more
  29 in total

Review 1.  Dopaminergic modulation of striatal function and Parkinson's disease.

Authors:  Shenyu Zhai; Weixing Shen; Steven M Graves; D James Surmeier
Journal:  J Neural Transm (Vienna)       Date:  2019-04-01       Impact factor: 3.575

2.  Optostimulation of striatonigral terminals in substantia nigra induces dyskinesia that increases after L-DOPA in a mouse model of Parkinson's disease.

Authors:  Ettel Keifman; Irene Ruiz-DeDiego; Diego Esteban Pafundo; Rodrigo Manuel Paz; Oscar Solís; Mario Gustavo Murer; Rosario Moratalla
Journal:  Br J Pharmacol       Date:  2019-05-21       Impact factor: 8.739

3.  Abnormal Cortico-Basal Ganglia Neurotransmission in a Mouse Model of l-DOPA-Induced Dyskinesia.

Authors:  Indriani Dwi Wahyu; Satomi Chiken; Taku Hasegawa; Hiromi Sano; Atsushi Nambu
Journal:  J Neurosci       Date:  2021-02-09       Impact factor: 6.167

Review 4.  Synaptic plasticity may underlie l-DOPA induced dyskinesia.

Authors:  Anders Borgkvist; Ori J Lieberman; David Sulzer
Journal:  Curr Opin Neurobiol       Date:  2017-11-07       Impact factor: 6.627

5.  Dopamine Triggers the Maturation of Striatal Spiny Projection Neuron Excitability during a Critical Period.

Authors:  Ori J Lieberman; Avery F McGuirt; Eugene V Mosharov; Irena Pigulevskiy; Benjamin D Hobson; Sejoon Choi; Micah D Frier; Emanuela Santini; Anders Borgkvist; David Sulzer
Journal:  Neuron       Date:  2018-07-26       Impact factor: 17.173

6.  Striatal D1 medium spiny neuron activation induces dyskinesias in parkinsonian mice.

Authors:  Xiomara A Perez; Danhui Zhang; Tanuja Bordia; Maryka Quik
Journal:  Mov Disord       Date:  2017-03-03       Impact factor: 10.338

7.  A Subpopulation of Striatal Neurons Mediates Levodopa-Induced Dyskinesia.

Authors:  Allison E Girasole; Matthew Y Lum; Diane Nathaniel; Chloe J Bair-Marshall; Casey J Guenthner; Liqun Luo; Anatol C Kreitzer; Alexandra B Nelson
Journal:  Neuron       Date:  2018-02-01       Impact factor: 17.173

8.  Enhanced GABA Transmission Drives Bradykinesia Following Loss of Dopamine D2 Receptor Signaling.

Authors:  Julia C Lemos; Danielle M Friend; Alanna R Kaplan; Jung Hoon Shin; Marcelo Rubinstein; Alexxai V Kravitz; Veronica A Alvarez
Journal:  Neuron       Date:  2016-05-18       Impact factor: 17.173

9.  Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M4 Muscarinic Receptor.

Authors:  Mark S Moehle; Tristano Pancani; Nellie Byun; Samantha E Yohn; George H Wilson; Johnathan W Dickerson; Daniel H Remke; Zixiu Xiang; Colleen M Niswender; Jürgen Wess; Carrie K Jones; Craig W Lindsley; Jerri M Rook; P Jeffrey Conn
Journal:  Neuron       Date:  2017-12-20       Impact factor: 17.173

10.  Cell-type-specific regulation of neuronal intrinsic excitability by macroautophagy.

Authors:  Ori J Lieberman; Micah D Frier; Avery F McGuirt; Christopher J Griffey; Elizabeth Rafikian; Mu Yang; Ai Yamamoto; Anders Borgkvist; Emanuela Santini; David Sulzer
Journal:  Elife       Date:  2020-01-08       Impact factor: 8.140
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.