Literature DB >> 33728194

Role of Monoclonal Antibody "Alemtuzumab" in the Treatment of Multiple Sclerosis.

Sadia Nosher1, Sehrish Fuad2, Nupur Mishra2, Zaid A Alrashid3,4, Bindu Rathod5, Devyani Mohan6, Deepak M Basavanagowda5, Arveen Kaur5, Stacey E Heindl2,7.   

Abstract

This article will review current treatment options for multiple sclerosis (MS) while keeping our primary focus on alemtuzumab, as it is now approved in more than 65 countries. From a pathophysiological point of view, MS is a disabling disease impacting a patient's life both physically and mentally, leading to devastating social and economic impact. This review will elaborate on alemtuzumab's role in treating relapsing-remitting MS (RRMS) by comparing its efficacy, side effects, and monitoring with other disease-modifying therapies (DMTs) available in the market. It is a point of great concern not only for physicians but also for neurologists, nephrologists, endocrinologists, dermatologists, and oncologists when encountering long-term effects of alemtuzumab in the life of treated MS patients. We hope that our review will not only benefit treating faculties but also those who are suffering from this devastating disease.
Copyright © 2021, Nosher et al.

Entities:  

Keywords:  alemtuzumab; disease-modifying therapies; immune-mediated thrombocytopenia; multiple sclerosis; nephropathy; secondary autoimmune diseases; thyroid disorders

Year:  2021        PMID: 33728194      PMCID: PMC7948316          DOI: 10.7759/cureus.13246

Source DB:  PubMed          Journal:  Cureus        ISSN: 2168-8184


  40 in total

1.  Neutropenia with fatal outcome in a multiple sclerosis patient 23 days after alemtuzumab infusion.

Authors:  Konstantina G Yiannopoulou; Dimitra Papadimitriou; Aikaterini I Anastasiou; Marina Siakantaris
Journal:  Mult Scler Relat Disord       Date:  2018-04-28       Impact factor: 4.339

Review 2.  Cytokine-release syndrome: overview and nursing implications.

Authors:  Sheila Breslin
Journal:  Clin J Oncol Nurs       Date:  2007-02       Impact factor: 1.027

3.  Sphingosine 1-phosphate signaling at the blood-brain barrier.

Authors:  Briana Prager; Simona F Spampinato; Richard M Ransohoff
Journal:  Trends Mol Med       Date:  2015-05-01       Impact factor: 11.951

4.  Hemophagocytic lymphohistiocytosis in 2 patients with multiple sclerosis treated with alemtuzumab.

Authors:  Mika Saarela; Keerthi Senthil; Joanne Jones; Pentti J Tienari; Merja Soilu-Hänninen; Laura Airas; Alasdair Coles; Jukka T Saarinen
Journal:  Neurology       Date:  2018-03-30       Impact factor: 9.910

5.  Interpreting Lymphocyte Reconstitution Data From the Pivotal Phase 3 Trials of Alemtuzumab.

Authors:  David Baker; Samuel S Herrod; Cesar Alvarez-Gonzalez; Gavin Giovannoni; Klaus Schmierer
Journal:  JAMA Neurol       Date:  2017-08-01       Impact factor: 18.302

6.  Risk factors for developing thyroid-associated ophthalmopathy among individuals with Graves disease.

Authors:  Joshua D Stein; David Childers; Shivani Gupta; Nidhi Talwar; Bin Nan; Brian J Lee; Terry J Smith; Raymond Douglas
Journal:  JAMA Ophthalmol       Date:  2015-03       Impact factor: 7.389

7.  Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial.

Authors:  Alasdair J Coles; Cary L Twyman; Douglas L Arnold; Jeffrey A Cohen; Christian Confavreux; Edward J Fox; Hans-Peter Hartung; Eva Havrdova; Krzysztof W Selmaj; Howard L Weiner; Tamara Miller; Elizabeth Fisher; Rupert Sandbrink; Stephen L Lake; David H Margolin; Pedro Oyuela; Michael A Panzara; D Alastair S Compston
Journal:  Lancet       Date:  2012-11-01       Impact factor: 79.321

8.  Intracerebral haemorrhage during alemtuzumab administration.

Authors:  Christina J Azevedo; Christen Kutz; Amy Dix; Aaron Boster; Nerses Sanossian; Jeffrey Kaplan
Journal:  Lancet Neurol       Date:  2019-02-15       Impact factor: 44.182

9.  Autoimmune disease after alemtuzumab treatment for multiple sclerosis in a multicenter cohort.

Authors:  M Cossburn; A A Pace; J Jones; R Ali; G Ingram; K Baker; C Hirst; J Zajicek; N Scolding; M Boggild; T Pickersgill; Y Ben-Shlomo; A Coles; N P Robertson
Journal:  Neurology       Date:  2011-07-27       Impact factor: 9.910

10.  A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis.

Authors:  Chris H Polman; Paul W O'Connor; Eva Havrdova; Michael Hutchinson; Ludwig Kappos; David H Miller; J Theodore Phillips; Fred D Lublin; Gavin Giovannoni; Andrzej Wajgt; Martin Toal; Frances Lynn; Michael A Panzara; Alfred W Sandrock
Journal:  N Engl J Med       Date:  2006-03-02       Impact factor: 91.245

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.