Catarina Sousa1,2, Paulo Nogueira3, Fausto J Pinto4,5. 1. Centro Cardiovascular da Universidade de Lisboa (CCUL), Centro Académico de Medicina de Lisboa (CAML), Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz MB, 1649-028, Lisbon, Portugal. catarinasousacardio@gmail.com. 2. Serviço de Cardiologia, Centro Hospitalar Barreiro Montijo (CHBM), EPE, Barreiro, Portugal. catarinasousacardio@gmail.com. 3. Área Disciplinar Autónoma de Bioestatística (Laboratório de Biomatemática), Instituto Medicina Preventiva E Saúde Publica, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz MB, Lisbon, 1649-028, Portugal. 4. Centro Cardiovascular da Universidade de Lisboa (CCUL), Centro Académico de Medicina de Lisboa (CAML), Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz MB, 1649-028, Lisbon, Portugal. 5. Departamento Do Coração E Vasos, Centro Hospitalar Universitário Lisboa Norte (CHULN), EPE, Lisbon, Portugal.
Abstract
BACKGROUND: Nationwide hospital admissions data series have contributed to a reliable assessment of the changing epidemiology of infective endocarditis, even though conclusions are not uniform. We sought to use a recent populational series to describe the temporal trends on the incidence of infective endocarditis, its clinical characteristics and outcome results, in Portugal. METHODS: A nationwide retrospective temporal trend study on the incidence and clinical characterization of patients hospitalized with infective endocarditis, between 2010 and 2018. RESULTS: 7574 patients were hospitalized with infective endocarditis from 2010 to 2018 in Portuguese public hospitals. The average length of hospitalization was 29.3 ± 28.7 days, predominantly men (56.9%), and 47.1% had between 60 and 79 years old. The most frequent infectious agents involved were Staphylococcus (16.4%) and Streptococcus (13.6%). During hospitalization, 12.4% of patients underwent heart valve surgery and 20% of the total cohort died. After a 1-year post-discharge follow-up, 13.2% of the total initial cohort had had heart valve surgery and 21.2% in total died. The annual incidence of infective endocarditis was 8.31 per 100,000 habitants, being higher in men (9.96 per 100,000 in males versus 6.82 in females, p < 0.001) and increased with age, peaking at patients 80 years old or older (40.62 per 100,000). In-hospital mortality rate significantly increased during the analyzed period, the strongest independent predictors being ischemic or hemorrhagic stroke, sepsis, and acute renal failure. Younger age and cardiac surgery had a protective effect towards a fatal outcome. CONCLUSIONS: In Portugal, between 2010 and 2018, the incidence of infective endocarditis presented a general growth trend with a deceleration in the most recent years. Also, a significant rate of in-hospital complications, a mildly lower than expected stable surgical rate and a still high and growing mortality rate were noted.
BACKGROUND: Nationwide hospital admissions data series have contributed to a reliable assessment of the changing epidemiology of infective endocarditis, even though conclusions are not uniform. We sought to use a recent populational series to describe the temporal trends on the incidence of infective endocarditis, its clinical characteristics and outcome results, in Portugal. METHODS: A nationwide retrospective temporal trend study on the incidence and clinical characterization of patients hospitalized with infective endocarditis, between 2010 and 2018. RESULTS: 7574 patients were hospitalized with infective endocarditis from 2010 to 2018 in Portuguese public hospitals. The average length of hospitalization was 29.3 ± 28.7 days, predominantly men (56.9%), and 47.1% had between 60 and 79 years old. The most frequent infectious agents involved were Staphylococcus (16.4%) and Streptococcus (13.6%). During hospitalization, 12.4% of patients underwent heart valve surgery and 20% of the total cohort died. After a 1-year post-discharge follow-up, 13.2% of the total initial cohort had had heart valve surgery and 21.2% in total died. The annual incidence of infective endocarditis was 8.31 per 100,000 habitants, being higher in men (9.96 per 100,000 in males versus 6.82 in females, p < 0.001) and increased with age, peaking at patients 80 years old or older (40.62 per 100,000). In-hospital mortality rate significantly increased during the analyzed period, the strongest independent predictors being ischemic or hemorrhagic stroke, sepsis, and acute renal failure. Younger age and cardiac surgery had a protective effect towards a fatal outcome. CONCLUSIONS: In Portugal, between 2010 and 2018, the incidence of infective endocarditis presented a general growth trend with a deceleration in the most recent years. Also, a significant rate of in-hospital complications, a mildly lower than expected stable surgical rate and a still high and growing mortality rate were noted.
Authors: João Pedro Ferreira; Filipa Gomes; Patrícia Rodrigues; Miguel Araújo Abreu; José Miguel Maia; Paulo Bettencourt; André Luz; Severo Torres; João Araújo Correia Journal: Rev Port Cardiol Date: 2013-10-25 Impact factor: 1.374
Authors: Xavier Duval; François Delahaye; François Alla; Pierre Tattevin; Jean-François Obadia; Vincent Le Moing; Thanh Doco-Lecompte; Marie Celard; Claire Poyart; Christophe Strady; Catherine Chirouze; Michelle Bes; Emmanuelle Cambau; Bernard Iung; Christine Selton-Suty; Bruno Hoen Journal: J Am Coll Cardiol Date: 2012-05-29 Impact factor: 24.094
Authors: Neusa Guiomar; M Vaz-da-Silva; D Mbala; B Sousa-Pinto; J P Monteiro; P Ponce; F Carneiro; F Neves; R Ferraz; D Rijo; M Teixeira; L Vouga; P Braga Journal: Rev Port Cardiol Date: 2020-04-25 Impact factor: 1.374
Authors: Karsten Keller; Ralph S von Bardeleben; Mir A Ostad; Lukas Hobohm; Thomas Munzel; Stavros Konstantinides; Mareike Lankeit Journal: Am J Cardiol Date: 2016-10-08 Impact factor: 2.778
Authors: Gilbert Habib; Patrizio Lancellotti; Manuel J Antunes; Maria Grazia Bongiorni; Jean-Paul Casalta; Francesco Del Zotti; Raluca Dulgheru; Gebrine El Khoury; Paola Anna Erba; Bernard Iung; Jose M Miro; Barbara J Mulder; Edyta Plonska-Gosciniak; Susanna Price; Jolien Roos-Hesselink; Ulrika Snygg-Martin; Franck Thuny; Pilar Tornos Mas; Isidre Vilacosta; Jose Luis Zamorano Journal: Eur Heart J Date: 2015-08-29 Impact factor: 29.983
Authors: Gilbert Habib; Bruno Hoen; Pilar Tornos; Franck Thuny; Bernard Prendergast; Isidre Vilacosta; Philippe Moreillon; Manuel de Jesus Antunes; Ulf Thilen; John Lekakis; Maria Lengyel; Ludwig Müller; Christoph K Naber; Petros Nihoyannopoulos; Anton Moritz; Jose Luis Zamorano Journal: Eur Heart J Date: 2009-08-27 Impact factor: 29.983
Authors: Ana Marques; Inês Cruz; Daniel Caldeira; Sofia Alegria; Ana Catarina Gomes; Ana Luísa Broa; Isabel João; Hélder Pereira Journal: Arq Bras Cardiol Date: 2020-01 Impact factor: 2.000
Authors: Ana Lopez-de-Andres; Rodrigo Jimenez-Garcia; Valentin Hernández-Barrera; Javier de-Miguel-Díez; Jose M de-Miguel-Yanes; David Martinez-Hernandez; David Carabantes-Alarcon; Jose J Zamorano-Leon; Concepción Noriega Journal: Cardiovasc Diabetol Date: 2022-09-30 Impact factor: 8.949