Gilbert Habib1,2, Paola Anna Erba3,4, Bernard Iung5, Erwan Donal6, Bernard Cosyns7, Cécile Laroche8, Bogdan A Popescu9, Bernard Prendergast10, Pilar Tornos11, Anita Sadeghpour12, Leopold Oliver13, Jolanta-Justina Vaskelyte14, Rouguiatou Sow15, Olivier Axler16, Aldo P Maggioni17, Patrizio Lancellotti18,19,20. 1. Cardiology Department, APHM, La Timone Hospital, Boulevard Jean Moulin, Marseille, France. 2. Aix Marseille University, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France. 3. Nuclear Medicine, Department of Translational Research and New Technology, Medicine University of Pisa and Azienda Ospedaliero Universitaria Pisana, Pisa, Italy. 4. Medical Imaging Center, University Medical Center Groningen, Groningen, The Netherlands. 5. Bichat Hospital, APHP, DHU Fire, Paris Diderot University, Paris, France. 6. University of Rennes, CHU Rennes, Inserm, LTSI - UMR 1099, Rennes, France. 7. Center for Cardiovascular Diseases (CHVZ), University Hospital Brussel, Brussels, Belgium. 8. EURObservational Research Programme (EORP), European Society of Cardiology, Sophia-Antipolis, France. 9. Department of Cardiology, University of Medicine and Pharmacy "Carol Davila" Euroecolab, Emergency Institute of Cardiovascular Diseases "Prof. Dr C. C. Iliescu", Bucharest, Romania. 10. Department of Cardiology, Guy's and St Thomas' Hospital, London, Great Britain. 11. Department of Cardiology, Hospital Quiron Barcelona. 12. Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. 13. Department of Cardiovascular Medicine, SOS Endocardites Unit, Henri-Mondor University Hospital, AP-HP, Creteil, France. 14. Department of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania. 15. Luxembourg Hospital Centre, Luxembourg. 16. Cardiology Department, Gaston Bourret Hospital Centre, New Caledonia University, Noumea, New Caledonia, France. 17. EURObservational Research Programme, European Society of Cardiology, France. 18. ANMCO Research Center, Florence, Italy. 19. Department of Cardiology, Heart Valve Clinic, University of Liege Hospital, GIGA Cardiovascular Sciences, CHU Sart Tilman, Liege, Belgium. 20. Gruppo Villa Maria Care and Research, Anthea Hospital, Bari, Italy.
Abstract
AIMS: The EURO-ENDO registry aimed to study the management and outcomes of patients with infective endocarditis (IE). METHODS AND RESULTS: Prospective cohort of 3116 adult patients (2470 from Europe, 646 from non-ESC countries), admitted to 156 hospitals in 40 countries between January 2016 and March 2018 with a diagnosis of IE based on ESC 2015 diagnostic criteria. Clinical, biological, microbiological, and imaging [echocardiography, computed tomography (CT) scan, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)] data were collected. Infective endocarditis was native (NVE) in 1764 (56.6%) patients, prosthetic (PVIE) in 939 (30.1%), and device-related (CDRIE) in 308 (9.9%). Infective endocarditis was community-acquired in 2046 (65.66%) patients. Microorganisms involved were staphylococci in 1085 (44.1%) patients, oral streptococci in 304 (12.3%), enterococci in 390 (15.8%), and Streptococcus gallolyticus in 162 (6.6%). 18F-fluorodeoxyglucose positron emission tomography/computed tomography was performed in 518 (16.6%) patients and presented with cardiac uptake (major criterion) in 222 (42.9%) patients, with a better sensitivity in PVIE (66.8%) than in NVE (28.0%) and CDRIE (16.3%). Embolic events occurred in 20.6% of patients, and were significantly associated with tricuspid or pulmonary IE, presence of a vegetation and Staphylococcus aureus IE. According to ESC guidelines, cardiac surgery was indicated in 2160 (69.3%) patients, but finally performed in only 1596 (73.9%) of them. In-hospital death occurred in 532 (17.1%) patients and was more frequent in PVIE. Independent predictors of mortality were Charlson index, creatinine > 2 mg/dL, congestive heart failure, vegetation length > 10 mm, cerebral complications, abscess, and failure to undertake surgery when indicated. CONCLUSION: Infective endocarditis is still a life-threatening disease with frequent lethal outcome despite profound changes in its clinical, microbiological, imaging, and therapeutic profiles. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: The EURO-ENDO registry aimed to study the management and outcomes of patients with infective endocarditis (IE). METHODS AND RESULTS: Prospective cohort of 3116 adult patients (2470 from Europe, 646 from non-ESC countries), admitted to 156 hospitals in 40 countries between January 2016 and March 2018 with a diagnosis of IE based on ESC 2015 diagnostic criteria. Clinical, biological, microbiological, and imaging [echocardiography, computed tomography (CT) scan, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)] data were collected. Infective endocarditis was native (NVE) in 1764 (56.6%) patients, prosthetic (PVIE) in 939 (30.1%), and device-related (CDRIE) in 308 (9.9%). Infective endocarditis was community-acquired in 2046 (65.66%) patients. Microorganisms involved were staphylococci in 1085 (44.1%) patients, oral streptococci in 304 (12.3%), enterococci in 390 (15.8%), and Streptococcus gallolyticus in 162 (6.6%). 18F-fluorodeoxyglucose positron emission tomography/computed tomography was performed in 518 (16.6%) patients and presented with cardiac uptake (major criterion) in 222 (42.9%) patients, with a better sensitivity in PVIE (66.8%) than in NVE (28.0%) and CDRIE (16.3%). Embolic events occurred in 20.6% of patients, and were significantly associated with tricuspid or pulmonary IE, presence of a vegetation and Staphylococcus aureus IE. According to ESC guidelines, cardiac surgery was indicated in 2160 (69.3%) patients, but finally performed in only 1596 (73.9%) of them. In-hospital death occurred in 532 (17.1%) patients and was more frequent in PVIE. Independent predictors of mortality were Charlson index, creatinine > 2 mg/dL, congestive heart failure, vegetation length > 10 mm, cerebral complications, abscess, and failure to undertake surgery when indicated. CONCLUSION:Infective endocarditis is still a life-threatening disease with frequent lethal outcome despite profound changes in its clinical, microbiological, imaging, and therapeutic profiles. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: B Lefèvre; B Hoen; F Goehringer; W Ngueyon Sime; N Aissa; C Alauzet; E Jeanmaire; S Hénard; L Filippetti; C Selton-Suty; N Agrinier Journal: Eur J Clin Microbiol Infect Dis Date: 2021-08-12 Impact factor: 3.267
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Authors: Sean Coffey; Ross Roberts-Thomson; Alex Brown; Jonathan Carapetis; Mao Chen; Maurice Enriquez-Sarano; Liesl Zühlke; Bernard D Prendergast Journal: Nat Rev Cardiol Date: 2021-06-25 Impact factor: 32.419