| Literature DB >> 19239885 |
Chris P Ponting1, Peter L Oliver, Wolf Reik.
Abstract
RNA is not only a messenger operating between DNA and protein. Transcription of essentially the entire eukaryotic genome generates a myriad of non-protein-coding RNA species that show complex overlapping patterns of expression and regulation. Although long noncoding RNAs (lncRNAs) are among the least well-understood of these transcript species, they cannot all be dismissed as merely transcriptional "noise." Here, we review the evolution of lncRNAs and their roles in transcriptional regulation, epigenetic gene regulation, and disease.Mesh：
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Year: 2009 PMID： 19239885 DOI： 10.1016/j.cell.2009.02.006
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582