Literature DB >> 33723389

RNA N6-methyladenosine: a new player in autophagy-mediated anti-cancer drug resistance.

Arumugam Paramasivam1, Jayaseelan Vijayashree Priyadharsini2.   

Abstract

Dysregulation of N6-methyladenosine (m6A) modification is associated with cancer development and progression. The m6A modification plays a crucial role in autophagy regulation precipitating anti-cancer drug resistance. In line with this fact, this commentary discusses m6A modification interfering with autophagy machinery as a major contributing factor for drug resistance in cancer.

Entities:  

Mesh：

Substances：

Year:  2021        PMID： 33723389      PMCID： PMC8110764          DOI： 10.1038/s41416-021-01314-z

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  12 in total

1.  FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylation.

Authors:  Shun Zhou; Zhou-Lan Bai; Di Xia; Zhi-Jun Zhao; Ren Zhao; Yan-Yang Wang; Hong Zhe
Journal:  Mol Carcinog       Date:  2018-02-01       Impact factor: 4.784

2.  RNA N-6-methyladenosine enzymes and resistance of cancer cells to chemotherapy and radiotherapy.

Authors:  Meiyi Xiang; Wensu Liu; Wei Tian; Abin You; Dajun Deng
Journal:  Epigenomics       Date:  2020-06-09       Impact factor: 4.778

3.  m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7.

Authors:  Xinxia Wang; Ruifan Wu; Youhua Liu; Yuanling Zhao; Zhen Bi; Yongxi Yao; Qing Liu; Hailing Shi; Fengqin Wang; Yizhen Wang
Journal:  Autophagy       Date:  2019-08-26       Impact factor: 16.016

Review 4.  m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer.

Authors:  Huilin Huang; Hengyou Weng; Jianjun Chen
Journal:  Cancer Cell       Date:  2020-03-16       Impact factor: 31.743

5.  The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells.

Authors:  Kosuke Taketo; Masamitsu Konno; Ayumu Asai; Jun Koseki; Masayasu Toratani; Taroh Satoh; Yuichiro Doki; Masaki Mori; Hideshi Ishii; Kazuhiko Ogawa
Journal:  Int J Oncol       Date:  2017-12-07       Impact factor: 5.650

6.  ALKBH5 inhibited autophagy of epithelial ovarian cancer through miR-7 and BCL-2.

Authors:  Hongtao Zhu; Xiaoling Gan; Xingwei Jiang; Shuai Diao; Huan Wu; Jianguo Hu
Journal:  J Exp Clin Cancer Res       Date:  2019-04-15

7.  m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.

Authors:  Seungwon Yang; Jiangbo Wei; Yan-Hong Cui; Gayoung Park; Palak Shah; Yu Deng; Andrew E Aplin; Zhike Lu; Seungmin Hwang; Chuan He; Yu-Ying He
Journal:  Nat Commun       Date:  2019-06-25       Impact factor: 14.919

8.  RNA m6 A methylation regulates sorafenib resistance in liver cancer through FOXO3-mediated autophagy.

Authors:  Ziyou Lin; Yi Niu; Arabella Wan; Dongshi Chen; Heng Liang; Xijun Chen; Lei Sun; Siyue Zhan; Liutao Chen; Chao Cheng; Xiaolei Zhang; Xianzhang Bu; Weiling He; Guohui Wan
Journal:  EMBO J       Date:  2020-05-05       Impact factor: 11.598

Review 9.  Autophagy and autophagy-related proteins in cancer.

Authors:  Xiaohua Li; Shikun He; Binyun Ma
Journal:  Mol Cancer       Date:  2020-01-22       Impact factor: 27.401
View more
  4 in total

Review 1.  Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance.

Authors:  Hong Lin; Yuxi Wang; Pinghan Wang; Fangyi Long; Ting Wang
Journal:  Mol Cancer       Date:  2022-07-18       Impact factor: 41.444

2.  METTL16 promotes hepatocellular carcinoma progression through downregulating RAB11B-AS1 in an m6A-dependent manner.

Authors:  Yun-Zhang Dai; Yong-da Liu; Jie Li; Mei-Ting Chen; Mei Huang; Fang Wang; Qing-Song Yang; Ji-Hang Yuan; Shu-Han Sun
Journal:  Cell Mol Biol Lett       Date:  2022-05-20       Impact factor: 8.702

3.  The Prognostic Value and Immune Landscapes of a m6A/m5C/m1A-Related LncRNAs Signature in Head and Neck Squamous Cell Carcinoma.

Authors:  Enhao Wang; Yang Li; Ruijie Ming; Jiahui Wei; Peiyu Du; Peng Zhou; Shimin Zong; Hongjun Xiao
Journal:  Front Cell Dev Biol       Date:  2021-11-30

4.  5-Azacytidine Inhibits the Activation of Senescence Program and Promotes Cytotoxic Autophagy during Trdmt1-Mediated Oxidative Stress Response in Insulinoma β-TC-6 Cells.

Authors:  Kamila Filip; Anna Lewińska; Jagoda Adamczyk-Grochala; Antonella Marino Gammazza; Francesco Cappello; Marianna Lauricella; Maciej Wnuk
Journal:  Cells       Date:  2022-04-04       Impact factor: 6.600
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.