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Literature DB >> 32183948

m⁶A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer.

Huilin Huang¹, Hengyou Weng², Jianjun Chen³.

Abstract

N6-Methyladenosine (m6A) RNA modification has emerged in recent years as a new layer of regulatory mechanism controlling gene expression in eukaryotes. As a reversible epigenetic modification found not only in messenger RNAs but also in non-coding RNAs, m6A affects the fate of the modified RNA molecules and plays important roles in almost all vital bioprocesses, including cancer development. Here we review the up-to-date knowledge of the pathological roles and underlying molecular mechanism of m6A modifications (in both coding and non-coding RNAs) in cancer pathogenesis and drug response/resistance, and discuss the therapeutic potential of targeting m6A regulators for cancer therapy.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: N(6)-methyladenosine (m(6)A); RNA modification; cancer epigenetics; cancer stem cells; drug resistance; epitranscriptome; immune therapy; non-coding RNA; prognosis; targeted therapeutics

Mesh：

Substances：

Year: 2020 PMID： 32183948 PMCID： PMC7141420 DOI： 10.1016/j.ccell.2020.02.004

Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743

187 in total

1. The methylated constituents of L cell messenger RNA: evidence for an unusual cluster at the 5' terminus.

Authors: R P Perry; D E Kelley; K Friderici; F Rottman
Journal: Cell Date: 1975-04 Impact factor: 41.582

Review 2. The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer.

Authors: Marcell Lederer; Nadine Bley; Christian Schleifer; Stefan Hüttelmaier
Journal: Semin Cancer Biol Date: 2014-07-25 Impact factor: 15.707

3. Cytoplasmic m⁶A reader YTHDF3 promotes mRNA translation.

Authors: Ang Li; Yu-Sheng Chen; Xiao-Li Ping; Xin Yang; Wen Xiao; Ying Yang; Hui-Ying Sun; Qin Zhu; Poonam Baidya; Xing Wang; Devi Prasad Bhattarai; Yong-Liang Zhao; Bao-Fa Sun; Yun-Gui Yang
Journal: Cell Res Date: 2017-01-20 Impact factor: 25.617

4. Ythdc2 is an N⁶-methyladenosine binding protein that regulates mammalian spermatogenesis.

Authors: Phillip J Hsu; Yunfei Zhu; Honghui Ma; Yueshuai Guo; Xiaodan Shi; Yuanyuan Liu; Meijie Qi; Zhike Lu; Hailing Shi; Jianying Wang; Yiwei Cheng; Guanzheng Luo; Qing Dai; Mingxi Liu; Xuejiang Guo; Jiahao Sha; Bin Shen; Chuan He
Journal: Cell Res Date: 2017-08-15 Impact factor: 25.617

Review 5. Roles and Regulation of Long Noncoding RNAs in Hepatocellular Carcinoma.

Authors: Lee Jin Lim; Samuel Y S Wong; Feiyang Huang; Sheng Lim; Samuel S Chong; London Lucien Ooi; Oi Lian Kon; Caroline G Lee
Journal: Cancer Res Date: 2019-07-23 Impact factor: 12.701

6. RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated.

Authors: Atsushi Tanabe; Kenya Tanikawa; Mai Tsunetomi; Kaori Takai; Hiroto Ikeda; Junpei Konno; Toshihiko Torigoe; Hideki Maeda; Goro Kutomi; Kenji Okita; Mitsuru Mori; Hiroeki Sahara
Journal: Cancer Lett Date: 2016-03-17 Impact factor: 8.679

7. Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome.

Authors: Bastian Linder; Anya V Grozhik; Anthony O Olarerin-George; Cem Meydan; Christopher E Mason; Samie R Jaffrey
Journal: Nat Methods Date: 2015-06-29 Impact factor: 28.547

8. Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m⁶A machinery component Wtap/Fl(2)d.

Authors: Philip Knuckles; Tina Lence; Irmgard U Haussmann; Dominik Jacob; Nastasja Kreim; Sarah H Carl; Irene Masiello; Tina Hares; Rodrigo Villaseñor; Daniel Hess; Miguel A Andrade-Navarro; Marco Biggiogera; Mark Helm; Matthias Soller; Marc Bühler; Jean-Yves Roignant
Journal: Genes Dev Date: 2018-03-13 Impact factor: 11.361

9. Single-base mapping of m⁶A by an antibody-independent method.

Authors: Zhang Zhang; Li-Qian Chen; Yu-Li Zhao; Cai-Guang Yang; Ian A Roundtree; Zijie Zhang; Jian Ren; Wei Xie; Chuan He; Guan-Zheng Luo
Journal: Sci Adv Date: 2019-07-03 Impact factor: 14.136

10. DART-seq: an antibody-free method for global m⁶A detection.

Authors: Kate D Meyer
Journal: Nat Methods Date: 2019-09-23 Impact factor: 28.547

241 in total

1. Identification of pathology-specific regulators of m⁶A RNA modification to optimize lung cancer management in the context of predictive, preventive, and personalized medicine.

Authors: Na Li; Xianquan Zhan
Journal: EPMA J Date: 2020-07-29 Impact factor: 6.543

Review 2. RNA N6-methyladenosine modification in regulating cancer stem cells and tumor immune microenvironment and its implication for cancer therapy.

Authors: Subhadra Kumari; Santosh Kumar; Srinivasan Muthuswamy
Journal: J Cancer Res Clin Oncol Date: 2022-07-07 Impact factor: 4.553

3. LEAD-m⁶ A-seq for Locus-Specific Detection of N⁶ -Methyladenosine and Quantification of Differential Methylation.

Authors: Yuru Wang; Zijie Zhang; Caraline Sepich-Poore; Lisheng Zhang; Yu Xiao; Chuan He
Journal: Angew Chem Int Ed Engl Date: 2020-11-10 Impact factor: 15.336

4. The m⁶A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis.

Authors: Rami Bechara; Nilesh Amatya; Rachel D Bailey; Yang Li; Felix E Y Aggor; De-Dong Li; Chetan V Jawale; Bianca M Coleman; Ning Dai; Nandan S Gokhale; Tiffany C Taylor; Stacy M Horner; Amanda C Poholek; Anita Bansal; Partha S Biswas; Sarah L Gaffen
Journal: Sci Immunol Date: 2021-07-02

10. FTO demethylates m6A modifications in HOXB13 mRNA and promotes endometrial cancer metastasis by activating the WNT signalling pathway.

Authors: Lin Zhang; Yicong Wan; Zihan Zhang; Yi Jiang; Jinghe Lang; Wenjun Cheng; Lan Zhu
Journal: RNA Biol Date: 2020-11-05 Impact factor: 4.652