Fatin Halim1,2, Hizwan Yahya1,2, Khairul Nizam Jaafar3, Syahir Mansor4,3. 1. Oncological and Radiological Science Cluster, Advanced Medical and Dental Institute, SAINS@BERTAM, Universiti Sains Malaysia, Penang, Malaysia. 2. Department of Nuclear Medicine, Penang Hospital, Penang, Malaysia; and. 3. Nuclear Medicine Unit, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, Malaysia. 4. Oncological and Radiological Science Cluster, Advanced Medical and Dental Institute, SAINS@BERTAM, Universiti Sains Malaysia, Penang, Malaysia; syahir.mansor@usm.my.
Abstract
Advances in iterative image reconstruction enable absolute quantification of SPECT/CT studies by incorporating compensations for collimator-detector response, attenuation, and scatter. This study aimed to assess the quantitative accuracy of SPECT/CT based on different levels of 99mTc activity (low/high) using different SUV metrics (SUVmean, SUVmax, SUV0.6 max, and SUV0.75 max [the average values that include pixels greater than 60% and 75% of the SUVmax in the volume of interest, respectively]). Methods: A Jaszczak phantom equipped with 6 fillable spheres was set up with low and high activity ratios of 1:4 and 1:10 (background-to-sphere) on background activities of 10 and 60 kBq/mL, respectively. The fixed-size volume of interest based on the diameter of each sphere was drawn on SPECT images using various metrics for SUV quantification purposes. Results: The convergence of activity concentration was dependent on the number of iterations and application of postfiltering. For the background-to-sphere ratio of 1:10 with a low background activity concentration, the SUVmean metric showed an underestimation of about 38% from the actual SUV, and SUVmax exhibited an overestimation of about 24% for the largest sphere diameter. Meanwhile, bias reductions of as much as -6% and -7% for SUV0.6 max and SUV0.75 max, respectively, were observed. SUVmax gave a more accurate reading than the others, although points that exceeded the actual value were detected. At 1:4 and 1:10 background activity of 10 kBq/mL, a low activity concentration attained a value close to the actual ratio. Use of 2 iterations and 10 subsets without postfiltering gave the most accurate values for reconstruction and the best image overall. Conclusion: SUVmax is the best metric in a high- or low-contrast-ratio phantom with at least 2 iterations, 10 subsets, and no postfiltering.
Advances in iterative image reconstruction enable absolute quantification of SPECT/CT studies by incorporating compensations for collimator-detector response, attenuation, and scatter. This study aimed to assess the quantitative accuracy of SPECT/CT based on different levels of 99mTc activity (low/high) using different SUV metrics (SUVmean, SUVmax, SUV0.6 max, and SUV0.75 max [the average values that include pixels greater than 60% and 75% of the SUVmax in the volume of interest, respectively]). Methods: A Jaszczak phantom equipped with 6 fillable spheres was set up with low and high activity ratios of 1:4 and 1:10 (background-to-sphere) on background activities of 10 and 60 kBq/mL, respectively. The fixed-size volume of interest based on the diameter of each sphere was drawn on SPECT images using various metrics for SUV quantification purposes. Results: The convergence of activity concentration was dependent on the number of iterations and application of postfiltering. For the background-to-sphere ratio of 1:10 with a low background activity concentration, the SUVmean metric showed an underestimation of about 38% from the actual SUV, and SUVmax exhibited an overestimation of about 24% for the largest sphere diameter. Meanwhile, bias reductions of as much as -6% and -7% for SUV0.6 max and SUV0.75 max, respectively, were observed. SUVmax gave a more accurate reading than the others, although points that exceeded the actual value were detected. At 1:4 and 1:10 background activity of 10 kBq/mL, a low activity concentration attained a value close to the actual ratio. Use of 2 iterations and 10 subsets without postfiltering gave the most accurate values for reconstruction and the best image overall. Conclusion: SUVmax is the best metric in a high- or low-contrast-ratio phantom with at least 2 iterations, 10 subsets, and no postfiltering.
Authors: Peter Knoll; Daniela Kotalova; Gunnar Köchle; Ivan Kuzelka; Greg Minear; Siroos Mirzaei; Martin Sámal; Ladislav Zadrazil; Helmar Bergmann Journal: Z Med Phys Date: 2011-07-01 Impact factor: 4.820
Authors: T Van den Wyngaert; K Strobel; W U Kampen; T Kuwert; W van der Bruggen; H K Mohan; G Gnanasegaran; R Delgado-Bolton; W A Weber; M Beheshti; W Langsteger; F Giammarile; F M Mottaghy; F Paycha Journal: Eur J Nucl Med Mol Imaging Date: 2016-06-04 Impact factor: 9.236