Literature DB >> 3372132

Trichosanthin, alpha-momorcharin and beta-momorcharin: identity of abortifacient and ribosome-inactivating proteins.

H W Yeung1, W W Li, Z Feng, L Barbieri, F Stirpe.   

Abstract

The abortifacient proteins trichosanthin, alpha-momorcharin and beta-momorcharin at nM concentrations inhibit cell-free protein synthesis. The momorcharins and the ribosome-inactivating proteins isolated from Momordica charantia seeds cross-react with the respective antisera. The ribosome-inactivating proteins saporins, pokeweed antiviral protein (PAP) and, to a lesser extent, gelonin have abortifacient activity on pregnant mice.

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Year:  1988        PMID： 3372132     DOI： 10.1111/j.1399-3011.1988.tb00033.x

Source DB:  PubMed          Journal:  Int J Pept Protein Res        ISSN： 0367-8377


  13 in total

1.  Cloning and characterisation of a gene encoding an antiviral protein from Clerodendrum aculeatum L.

Authors:  D Kumar; H N Verma; N Tuteja; K K Tewari
Journal:  Plant Mol Biol       Date:  1997-03       Impact factor: 4.076

Review 2.  Targeted kill: from umbrellas to monoclonal antibodies.

Authors:  V S Byers; R W Baldwin
Journal:  J Clin Immunol       Date:  1992-11       Impact factor: 8.317

3.  A maize ribosome-inactivating protein is controlled by the transcriptional activator Opaque-2.

Authors:  H W Bass; C Webster; G R OBrian; J K Roberts; R S Boston
Journal:  Plant Cell       Date:  1992-02       Impact factor: 11.277

4.  Trichosanthin, a potent HIV-1 inhibitor, can cleave supercoiled DNA in vitro.

Authors:  M X Li; H W Yeung; L P Pan; S I Chan
Journal:  Nucleic Acids Res       Date:  1991-11-25       Impact factor: 16.971

Review 5.  The role of plant-derived drugs and herbal medicines in healthcare.

Authors:  P A De Smet
Journal:  Drugs       Date:  1997-12       Impact factor: 9.546

6.  Studies on crystal structures, active-centre geometry and depurinating mechanism of two ribosome-inactivating proteins.

Authors:  Q Huang; S Liu; Y Tang; S Jin; Y Wang
Journal:  Biochem J       Date:  1995-07-01       Impact factor: 3.857

7.  The mechanism of action of trichosanthin on eukaryotic ribosomes--RNA N-glycosidase activity of the cytotoxin.

Authors:  J S Zhang; W Y Liu
Journal:  Nucleic Acids Res       Date:  1992-03-25       Impact factor: 16.971

8.  Antiviral activity of shiga toxin requires enzymatic activity and is associated with increased permeability of the target cells.

Authors:  Indira Basu; Witold A Ferens; Diana M Stone; Carolyn J Hovde
Journal:  Infect Immun       Date:  2003-01       Impact factor: 3.441

Review 9.  Ribosome-inactivating proteins: from plant defense to tumor attack.

Authors:  Maddalena de Virgilio; Alessio Lombardi; Rocco Caliandro; Maria Serena Fabbrini
Journal:  Toxins (Basel)       Date:  2010-11-10       Impact factor: 4.546

10.  Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors.

Authors:  J Zhao; L H Ben; Y L Wu; W Hu; K Ling; S M Xin; H L Nie; L Ma; G Pei
Journal:  J Exp Med       Date:  1999-07-05       Impact factor: 14.307
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