Literature DB >> 33718279

Clinical Experience of Personalized Phage Therapy Against Carbapenem-Resistant Acinetobacter baumannii Lung Infection in a Patient With Chronic Obstructive Pulmonary Disease.

Xin Tan1, Huaisheng Chen2, Min Zhang3,4, Ying Zhao5, Yichun Jiang2, Xueyan Liu2, Wei Huang3,4, Yingfei Ma1.   

Abstract

Overuse of antibiotics in clinical medicine has contributed to the global spread of multidrug-resistant bacterial pathogens, including Acinetobacter baumannii. We present a case of an 88-year-old Chinese man who developed hospital-acquired pneumonia caused by carbapenem-resistant A. baumannii (CRAB). A personalized lytic pathogen-specific single-phage preparation was nebulized to the patient continuously for 16 days in combination with tigecycline and polymyxin E. The treatment was well tolerated and resulted in clearance of the pathogen and clinical improvement of the patient's lung function.
Copyright © 2021 Tan, Chen, Zhang, Zhao, Jiang, Liu, Huang and Ma.

Entities:  

Keywords:  carbapenem-resistant Acinetobacter baumannii; endotoxin; lung infection; personalized phage therapy; phage

Mesh：

Substances：

Year:  2021        PMID： 33718279      PMCID： PMC7952606          DOI： 10.3389/fcimb.2021.631585

Source DB:  PubMed          Journal:  Front Cell Infect Microbiol        ISSN： 2235-2988            Impact factor:   5.293


  24 in total

1.  Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials.

Authors:  Fernando Gordillo Altamirano; John H Forsyth; Ruzeen Patwa; Xenia Kostoulias; Michael Trim; Dinesh Subedi; Stuart K Archer; Faye C Morris; Cody Oliveira; Luisa Kielty; Denis Korneev; Moira K O'Bryan; Trevor J Lithgow; Anton Y Peleg; Jeremy J Barr
Journal:  Nat Microbiol       Date:  2021-01-11       Impact factor: 17.745

2.  Practical procedures for the purification of bacterial viruses.

Authors:  U Bachrach; A Friedmann
Journal:  Appl Microbiol       Date:  1971-10

Review 3.  New Treatment Options against Carbapenem-Resistant Acinetobacter baumannii Infections.

Authors:  Burcu Isler; Yohei Doi; Robert A Bonomo; David L Paterson
Journal:  Antimicrob Agents Chemother       Date:  2018-12-21       Impact factor: 5.191

4.  Characterization of the inflammatory response to inhaled lipopolysaccharide in mild to moderate chronic obstructive pulmonary disease.

Authors:  Vandana Gupta; Antonia Banyard; Aoibheann Mullan; Srividya Sriskantharajah; Thomas Southworth; Dave Singh
Journal:  Br J Clin Pharmacol       Date:  2015-05       Impact factor: 4.335

Review 5.  Acinetobacter baumannii: epidemiology, antimicrobial resistance, and treatment options.

Authors:  Lisa L Maragakis; Trish M Perl
Journal:  Clin Infect Dis       Date:  2008-04-15       Impact factor: 9.079

6.  Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis.

Authors:  Evelina Tacconelli; Elena Carrara; Alessia Savoldi; Stephan Harbarth; Marc Mendelson; Dominique L Monnet; Céline Pulcini; Gunnar Kahlmeter; Jan Kluytmans; Yehuda Carmeli; Marc Ouellette; Kevin Outterson; Jean Patel; Marco Cavaleri; Edward M Cox; Chris R Houchens; M Lindsay Grayson; Paul Hansen; Nalini Singh; Ursula Theuretzbacher; Nicola Magrini
Journal:  Lancet Infect Dis       Date:  2017-12-21       Impact factor: 71.421

7.  Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus.

Authors:  Rebekah M Dedrick; Carlos A Guerrero-Bustamante; Rebecca A Garlena; Daniel A Russell; Katrina Ford; Kathryn Harris; Kimberly C Gilmour; James Soothill; Deborah Jacobs-Sera; Robert T Schooley; Graham F Hatfull; Helen Spencer
Journal:  Nat Med       Date:  2019-05-08       Impact factor: 53.440

8.  Characterization and genomic analysis of ValSw3-3, a new Siphoviridae bacteriophage infecting Vibrio alginolyticus.

Authors:  Ling Chen; Quan Liu; Jiqiang Fan; Tingwei Yan; Haoran Zhang; Jinfang Yang; Deng Deng; Chaolan Liu; Ting Wei; Yingfei Ma
Journal:  J Virol       Date:  2020-03-04       Impact factor: 5.103

9.  SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler.

Authors:  Ruibang Luo; Binghang Liu; Yinlong Xie; Zhenyu Li; Weihua Huang; Jianying Yuan; Guangzhu He; Yanxiang Chen; Qi Pan; Yunjie Liu; Jingbo Tang; Gengxiong Wu; Hao Zhang; Yujian Shi; Yong Liu; Chang Yu; Bo Wang; Yao Lu; Changlei Han; David W Cheung; Siu-Ming Yiu; Shaoliang Peng; Zhu Xiaoqian; Guangming Liu; Xiangke Liao; Yingrui Li; Huanming Yang; Jian Wang; Tak-Wah Lam; Jun Wang
Journal:  Gigascience       Date:  2012-12-27       Impact factor: 6.524

10.  The RAST Server: rapid annotations using subsystems technology.

Authors:  Ramy K Aziz; Daniela Bartels; Aaron A Best; Matthew DeJongh; Terrence Disz; Robert A Edwards; Kevin Formsma; Svetlana Gerdes; Elizabeth M Glass; Michael Kubal; Folker Meyer; Gary J Olsen; Robert Olson; Andrei L Osterman; Ross A Overbeek; Leslie K McNeil; Daniel Paarmann; Tobias Paczian; Bruce Parrello; Gordon D Pusch; Claudia Reich; Rick Stevens; Olga Vassieva; Veronika Vonstein; Andreas Wilke; Olga Zagnitko
Journal:  BMC Genomics       Date:  2008-02-08       Impact factor: 3.969
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  12 in total

1.  Isolation and Characterisation of Bacteriophage Selective for Key Acinetobacter baumannii Capsule Chemotypes.

Authors:  Rosesathorn Soontarach; Potjanee Srimanote; Mark C Enright; George Blundell-Hunter; Matthew J Dorman; Nicholas R Thomson; Peter W Taylor; Supayang P Voravuthikunchai
Journal:  Pharmaceuticals (Basel)       Date:  2022-04-02

2.  Genetic Signatures from Adaptation of Bacteria to Lytic Phage Identify Potential Agents To Aid Phage Killing of Multidrug-Resistant Acinetobacter baumannii.

Authors:  Greater Kayode Oyejobi; Dongyan Xiong; Mengjuan Shi; Xiaoxu Zhang; Hang Yang; Heng Xue; Faith Ogolla; Hongping Wei
Journal:  J Bacteriol       Date:  2022-02-14       Impact factor: 3.476

Review 3.  Essential Topics for the Regulatory Consideration of Phages as Clinically Valuable Therapeutic Agents: A Perspective from Spain.

Authors:  Roberto Vázquez; Roberto Díez-Martínez; Pilar Domingo-Calap; Pedro García; Diana Gutiérrez; Maite Muniesa; María Ruiz-Ruigómez; Rafael Sanjuán; María Tomás; María Ángeles Tormo-Mas; Pilar García
Journal:  Microorganisms       Date:  2022-03-26

4.  Phage-antibiotic combination is a superior treatment against Acinetobacter baumannii in a preclinical study.

Authors:  Fernando L Gordillo Altamirano; Xenia Kostoulias; Dinesh Subedi; Denis Korneev; Anton Y Peleg; Jeremy J Barr
Journal:  EBioMedicine       Date:  2022-05-07       Impact factor: 11.205

Review 5.  Phage Therapy in the Era of Multidrug Resistance in Bacteria: A Systematic Review.

Authors:  Carlos Aranaga; Lady Daniela Pantoja; Edgar Andrés Martínez; Aura Falco
Journal:  Int J Mol Sci       Date:  2022-04-21       Impact factor: 6.208

6.  Involvement of a Phage-Encoded Wzy Protein in the Polymerization of K127 Units To Form the Capsular Polysaccharide of Acinetobacter baumannii Isolate 36-1454.

Authors:  Ruth M Hall; Yuriy A Knirel; Johanna J Kenyon; Nikolay P Arbatsky; Anastasiya A Kasimova; Alexander S Shashkov; Mikhail M Shneider; Anastasiya V Popova; Dmitry A Shagin; Andrey A Shelenkov; Yuliya V Mikhailova; Yurii G Yanushevich
Journal:  Microbiol Spectr       Date:  2022-04-27

Review 7.  Prospects of Inhaled Phage Therapy for Combatting Pulmonary Infections.

Authors:  Xiang Wang; Zuozhou Xie; Jinhong Zhao; Zhenghua Zhu; Chen Yang; Yi Liu
Journal:  Front Cell Infect Microbiol       Date:  2021-12-06       Impact factor: 5.293

8.  Enhanced antibacterial effect of a novel Friunavirus phage vWU2001 in combination with colistin against carbapenem-resistant Acinetobacter baumannii.

Authors:  Phitchayapak Wintachai; Narumon Phaonakrop; Sittiruk Roytrakul; Ampapan Naknaen; Rattanaruji Pomwised; Supayang Piyawan Voravuthikunchai; Komwit Surachat; Duncan R Smith
Journal:  Sci Rep       Date:  2022-02-16       Impact factor: 4.379

Review 9.  Gram-Negative Bacteria Holding Together in a Biofilm: The Acinetobacter baumannii Way.

Authors:  Arianna Pompilio; Daniela Scribano; Meysam Sarshar; Giovanni Di Bonaventura; Anna Teresa Palamara; Cecilia Ambrosi
Journal:  Microorganisms       Date:  2021-06-22

10.  Improving Phage-Biofilm In Vitro Experimentation.

Authors:  Stephen T Abedon; Katarzyna M Danis-Wlodarczyk; Daniel J Wozniak; Matthew B Sullivan
Journal:  Viruses       Date:  2021-06-19       Impact factor: 5.048
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