Felicidade Mota Pereira1,2, Pablo Ivan Pereira Ramos3, Monique Lirio1, Ajax Mercês Atta4, Isabela Silva de Oliveira4, Fabio Carneiro Vosqui Nascimento5, Marcelo Costa Silva6, Bernardo Galvão-Castro7, Maria Fernanda Rios Grassi1,7. 1. Laboratório Avançado de Saúde Pública, Fundação Oswaldo Cruz, Salvador, Brazil. 2. Laboratório Central de Saúde Pública Prof. Gonçalo Moniz - Secretaria da Saúde do Estado da Bahia, Salvador, Brazil. 3. Centro de Integração de Dados e Conhecimentos para Saúde - CIDACS, Fundação Oswaldo Cruz, Salvador, Brazil. 4. Faculdade de Farmácia, Universidade Federal da Bahia, Salvador, Brazil. 5. Secretaria Municipal de Saúde de Feira de Santana, Feira de Santana, Brazil. 6. Secretaria da Saúde do Estado da Bahia, Salvador, Brazil. 7. Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil.
Abstract
BACKGROUND: Co-infection between the human T-cell lymphotropic virus (HTLV) and the hepatitis C virus (HCV) can modify the natural history of HCV infection. The aim of this study was to describe the inflammatory cytokines and IL-10 network in patients co-infected with HTLV and HCV viruses in Bahia, Brazil. METHODS: Samples from 31 HTLV/HCV co-infected individuals and 27 HCV monoinfected individuals were evaluated. IFN-γ, TNF-α, IL-10, IL-8, and IL-1 cytokines were quantified by ELISA. Clinical, laboratory data were obtained from patient records. Serum levels of the cytokines were log10-transformed and data mining was performed using Z-score statistics and correlation analysis. RESULTS: Co-infected individuals presented a tendency toward higher production of INF-γ compared to the HCV monoinfected group. Regarding cytokine pairs, there was a positive correlation (P-value < 0.05) between IL-1 and IL-8 in the HTLV/HCV co-infected group and uninfected controls, and two correlations in the HCV mono-infected group IL-8 - IL10 and IL- INF-γ - IL-10 pairs. There was no significant difference between the groups for the other parameters analyzed. CONCLUSION: The results presented herein indicated that HTLV/HCV co-infection was associated with a trend in IFN-γ production while HCV-infected individuals presented a positive correlation with both inflammatory cytokines (IL-8 and IFN-γ) and the regulatory cytokine IL-10.
BACKGROUND: Co-infection between the human T-cell lymphotropic virus (HTLV) and the hepatitis C virus (HCV) can modify the natural history of HCV infection. The aim of this study was to describe the inflammatory cytokines and IL-10 network in patients co-infected with HTLV and HCV viruses in Bahia, Brazil. METHODS: Samples from 31 HTLV/HCV co-infected individuals and 27 HCV monoinfected individuals were evaluated. IFN-γ, TNF-α, IL-10, IL-8, and IL-1 cytokines were quantified by ELISA. Clinical, laboratory data were obtained from patient records. Serum levels of the cytokines were log10-transformed and data mining was performed using Z-score statistics and correlation analysis. RESULTS: Co-infected individuals presented a tendency toward higher production of INF-γ compared to the HCV monoinfected group. Regarding cytokine pairs, there was a positive correlation (P-value < 0.05) between IL-1 and IL-8 in the HTLV/HCV co-infected group and uninfected controls, and two correlations in the HCV mono-infected group IL-8 - IL10 and IL- INF-γ - IL-10 pairs. There was no significant difference between the groups for the other parameters analyzed. CONCLUSION: The results presented herein indicated that HTLV/HCV co-infection was associated with a trend in IFN-γ production while HCV-infected individuals presented a positive correlation with both inflammatory cytokines (IL-8 and IFN-γ) and the regulatory cytokine IL-10.
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