Antonio Rivero-Juarez1, Mario Frias1, Pedro Lopez-Lopez1, Juan Berenguer2, Federico García3, Juan Macias4, Begoña Alcaraz5, Angeles Castro-Iglesias6, Javier Caballero-Gomez1,7, Antonio Rivero1. 1. Instituto Maimonides de Investigación Biomédica de Córdoba, Hospital Universitario Reina Sofía de Córdoba, Universidad de Córdoba, Córdoba, Spain. 2. Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain. 3. Hospital Universitario San Cecilio, Instituto de Investigación Biosantaria Ibs, Granada, Spain. 4. Hospital Nuestra Señora de Valme, Seville, Spain. 5. Hospital General Universitario Santa Lucía, Cartagena, Spain. 6. Complejo Hospitalario Universitario a Coruña, A Coruña, Spain. 7. University of Córdoba - Agrifood Excellence International Campus, Córdoba, Spain.
Abstract
BACKGROUND: The objective of our study was to assess the prevalence and incidence of HEV in people living with HIV (PLWH) in a Spanish national cohort. METHODS: Retrospective longitudinal study including PLWH recruited in the cohort of adult HIV-infected patients of the AIDS Research Network in follow-up at 28 Spanish hospitals with available serum samples in 2014 and 2015. All samples were tested for HEV IgG, IgM, and RNA. Samples with detectable HEV viral loads were genotyped. Prevalence and incidence of HEV infection were calculated. RESULTS: The study sample comprised 845 PLWH. At baseline, 101 patients were positive for HEV IgG antibodies (11.9%), none had HEV IgM antibodies, and 2 presented detectable HEV RNA (0.23%). Forty-two seroconverted for IgG, supposing a cumulative incidence of 5.7%. One subject was positive for IgM (0.13%), and 2 showed detectable HEV RNA (0.27%). One case was infected by the emergent HEV genotype 3ra. CONCLUSION: Our study identifies one case of HEV 3ra genotype infection, the main host of which is rabbit, showing a potential zoonotic role of this emerging genotype in Spain.
BACKGROUND: The objective of our study was to assess the prevalence and incidence of HEV in people living with HIV (PLWH) in a Spanish national cohort. METHODS: Retrospective longitudinal study including PLWH recruited in the cohort of adult HIV-infected patients of the AIDS Research Network in follow-up at 28 Spanish hospitals with available serum samples in 2014 and 2015. All samples were tested for HEV IgG, IgM, and RNA. Samples with detectable HEV viral loads were genotyped. Prevalence and incidence of HEV infection were calculated. RESULTS: The study sample comprised 845 PLWH. At baseline, 101 patients were positive for HEV IgG antibodies (11.9%), none had HEV IgM antibodies, and 2 presented detectable HEV RNA (0.23%). Forty-two seroconverted for IgG, supposing a cumulative incidence of 5.7%. One subject was positive for IgM (0.13%), and 2 showed detectable HEV RNA (0.27%). One case was infected by the emergent HEV genotype 3ra. CONCLUSION: Our study identifies one case of HEV 3ra genotype infection, the main host of which is rabbit, showing a potential zoonotic role of this emerging genotype in Spain.
Authors: Javier Caballero-Gómez; Saul Jiménez-Ruiz; Pedro Lopez-Lopez; Joaquin Vicente; Maria A Risalde; David Cano-Terriza; Mario Frias; Jose A Barasona; Antonio Rivero; Ignacio García-Bocanegra; Antonio Rivero-Juarez Journal: Transbound Emerg Dis Date: 2019-06-07 Impact factor: 5.005
Authors: Antonio Rivero-Juarez; Loreto Martinez-Dueñas; Antonio Martinez-Peinado; Angela Camacho; Celia Cifuentes; Ana Gordon; Mario Frias; Julian Torre-Cisneros; Juan A Pineda; Antonio Rivero Journal: J Infect Date: 2014-11-05 Impact factor: 6.072
Authors: Antonio Rivero-Juárez; Antonio Aguilera; Ana Avellón; Miguel García-Deltoro; Federico García; Christian Gortazar; Rafael Granados; Juan Macías; Nicolás Merchante; José Antonio Oteo; María Teresa Pérez-Gracia; Juan Antonio Pineda; Antonio Rivero; David Rodriguez-Lazaro; Francisco Téllez; Luis E Morano-Amado Journal: Enferm Infecc Microbiol Clin (Engl Ed) Date: 2018-07-30
Authors: Donald B Smith; Peter Simmonds; Jacques Izopet; Edmilson F Oliveira-Filho; Rainer G Ulrich; Reimar Johne; Matthias Koenig; Shahid Jameel; Tim J Harrison; Xiang-Jin Meng; Hiroaki Okamoto; Wim H M Van der Poel; Michael A Purdy Journal: J Gen Virol Date: 2016-01-07 Impact factor: 3.891
Authors: Vanessa Suin; Sofieke E Klamer; Veronik Hutse; Magali Wautier; Marjorie Jacques; Mona Abady; Sophie Lamoral; Vera Verburgh; Isabelle Thomas; Bernard Brochier; Lorenzo Subissi; Steven Van Gucht Journal: Euro Surveill Date: 2019-03
Authors: Siddharth Sridhar; Cyril C Y Yip; Shusheng Wu; Jianpiao Cai; Anna Jin-Xia Zhang; Kit-Hang Leung; Tom W H Chung; Jasper F W Chan; Wan-Mui Chan; Jade L L Teng; Rex K H Au-Yeung; Vincent C C Cheng; Honglin Chen; Susanna K P Lau; Patrick C Y Woo; Ning-Shao Xia; Chung-Mau Lo; Kwok-Yung Yuen Journal: Emerg Infect Dis Date: 2018-12 Impact factor: 6.883