Literature DB >> 33716767

Antioxidant and Protective Effects of Artemisia campestris Essential Oil Against Chlorpyrifos-Induced Kidney and Liver Injuries in Rats.

Mongi Saoudi1, Riadh Badraoui2,3,4, Fatma Rahmouni4, Kamel Jamoussi5, Abdelfattah El Feki1.   

Abstract

This study is aimed to elucidate the possible antioxidant and protective effects of Artemisia campestris essential oil (ACEO) against the deleterious effects of chlorpyrifos (CPF) in rats. The in vivo study revealed increases in aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP) activities and the serum contents of creatinine, urea, uric acid, cholesterol, triglycerides, low density lipoproteins (LDL), and glucose in rats treated with CPF as compared to controls. Meanwhile, hepatic and renal activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in liver and kidney decreased and the content of malondialdehyde (MDA) increased. Some histopathologic features were noticed in liver and kidney of the CPF group. Interestingly, ACEO alleviated the biochemical disruptions and reduced these hepato-renal morphologic changes.
Copyright © 2021 Saoudi, Badraoui, Rahmouni, Jamoussi and El Feki.

Entities:  

Keywords:  Artemisia campestris essential oil; chlorpyrifos toxicity; kidney injury; liver injury; oxidative stress

Year:  2021        PMID： 33716767      PMCID： PMC7945717          DOI： 10.3389/fphys.2021.618582

Source DB:  PubMed          Journal:  Front Physiol        ISSN： 1664-042X            Impact factor:   4.566


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