Literature DB >> 337164

[Biosynthesis and structure of the yeast fatty acid synthetase complex].

E Schweizer.   

Abstract

Genetic as well as biochemical data suggest that the yeast fatty-acid synthetase complex has an (AB)6 protein structure where A and B represent multifunctional polypeptide chains with molecular weights of 185000 and 180000 daltons, respectively. Subunit A contains at least 3 and subunit B4 of the 8 known biochemical functions of the multienzyme complex. It is concluded that this complex structure has evolved from the corresponding prokaryotic system of monofunctional enzymes due to a selective advantage regarding the biosynthesis and assembly of the complex components.

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Year:  1977        PMID： 337164     DOI： 10.1007/bf00368735

Source DB:  PubMed          Journal:  Naturwissenschaften        ISSN： 0028-1042


  39 in total

1.  Presence of two polypeptide chains comprising fatty acid synthetase.

Authors:  J K Stoops; M J Arslanian; Y H Oh; K C Aune; T C Vanaman; S J Wakil
Journal:  Proc Natl Acad Sci U S A       Date:  1975-05       Impact factor: 11.205

2.  Fatty acid synthesis in adipose tissue. I. Purification and properties of a long chain fatty acid-synthesizing system.

Authors:  D B MARTIN; M G HORNING; P R VAGELOS
Journal:  J Biol Chem       Date:  1961-03       Impact factor: 5.157

3.  Fine structure analysis of a eukaryotic multifunctional gene.

Authors:  A P Bollon
Journal:  Nature       Date:  1974-08-23       Impact factor: 49.962

4.  Structural homology of the glutamine amidotransferase subunits of the anthranilate synthetases of Escherichia coli, Salmonella typhimurium and Serratia marcescens.

Authors:  S L Li; J Hanlon; C Yanofsky
Journal:  Nature       Date:  1974-03-01       Impact factor: 49.962

5.  Pantetheine-free mutants of the yeast fatty-acid-synthetase complex.

Authors:  E Schweizer; B Kniep; H Castorph; U Holzner
Journal:  Eur J Biochem       Date:  1973-11-15

Review 6.  The formation and stabilization of protein structure.

Authors:  C B Anfinsen
Journal:  Biochem J       Date:  1972-07       Impact factor: 3.857

7.  Fatty-acid elongation in a mutant of Saccharomyces cerevisiae deficient in fatty-acid synthetase.

Authors:  T W Orme; J McIntyre; F Lynen; L Kühn; E Schweizer
Journal:  Eur J Biochem       Date:  1972-01-21

8.  A new gene cluster in yeast: the fatty acid synthetase system.

Authors:  E Schweizer; L Kühn; H Castorph
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1971-03

9.  End group analysis of yeast fatty acid synthetase.

Authors:  H Schwietz; G Dietlein; E Schiltz; E Schweizer
Journal:  Biochim Biophys Acta       Date:  1976-12-22

10.  Saturated fatty acid mutant of Saccharomyces cerevisiae with an intact fatty acid synthetase.

Authors:  K H Meyer; E Schweizer
Journal:  J Bacteriol       Date:  1974-02       Impact factor: 3.490
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  1 in total

Review 1.  Fatty acid biosynthesis in yeast.

Authors:  E Schweizer; K Werkmeister; M K Jain
Journal:  Mol Cell Biochem       Date:  1978-11-01       Impact factor: 3.396
  1 in total

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