Ceyda Karadağ1, Sertaç Esin2, Yusuf Aytaç Tohma2, Ethem Serdar Yalvaç3, Tuğrul Başar4, Burak Karadağ5. 1. Akdeniz University Faculty of Medicine, Department of Obstetrics and Gynecology, Antalya, Turkey. 2. Başkent University Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey. 3. Bozok University Faculty of Medicine, Department of Obstetrics and Gynecology, Yozgat, Turkey. 4. Ankara Gölbaşı Şehit Ahmet Özsoy State Hospital, Clinic of Obstetrics and Gynecology Ankara, Turkey. 5. Antalya Training and Research Hospital, Clinic of Obstetrics and Gynecology Antalya, Turkey.
Abstract
OBJECTIVE: To compare the obstetric and neonatal outcomes of patients treated with repeated-dose prostaglandin E2 (dinoprostone) vaginal insert when the first dose fails. MATERIALS AND METHODS: This retrospective study included 1.043 pregnant women who received dinoprostone for labor induction between November 2012 and August 2015. Pregnant women were divided into two groups according to the number of dinoprostone administrations: group 1, single-dose dinoprostone (n=1.000), and group 2, repeated-dose dinoprostone (n=43). Intrapartum, postpartum, and neonatal outcomes of the pregnant women were compared. RESULTS: Vaginal delivery rate was 65% in group 1 and 30.2% in group 2 (p=0.001). The need for the neonatal intensive care unit was found in 44 pregnant women (4.4%) in group 1 and 6 pregnant women (13.6%) in group 2 (p=0.006). CONCLUSION: When obstetric and neonatal data were evaluated in our study, we observed that dinoprostone administration was associated with increased cesarean rates and adverse neonatal outcomes with repeated-dose dinoprostone when the first dose failed.
OBJECTIVE: To compare the obstetric and neonatal outcomes of patients treated with repeated-dose prostaglandin E2 (dinoprostone) vaginal insert when the first dose fails. MATERIALS AND METHODS: This retrospective study included 1.043 pregnant women who received dinoprostone for labor induction between November 2012 and August 2015. Pregnant women were divided into two groups according to the number of dinoprostone administrations: group 1, single-dose dinoprostone (n=1.000), and group 2, repeated-dose dinoprostone (n=43). Intrapartum, postpartum, and neonatal outcomes of the pregnant women were compared. RESULTS: Vaginal delivery rate was 65% in group 1 and 30.2% in group 2 (p=0.001). The need for the neonatal intensive care unit was found in 44 pregnant women (4.4%) in group 1 and 6 pregnant women (13.6%) in group 2 (p=0.006). CONCLUSION: When obstetric and neonatal data were evaluated in our study, we observed that dinoprostone administration was associated with increased cesarean rates and adverse neonatal outcomes with repeated-dose dinoprostone when the first dose failed.
Authors: Mohammed T Gadel Rab; Abdel Baset F Mohammed; Khalid A Zahran; Mo'men M Hassan; Abdel Razek M Eldeen; Emad M Ebrahim; Mohammed Yehia Journal: J Matern Fetal Neonatal Med Date: 2014-08-14
Authors: Farnaz K Aghideh; Patrick M Mullin; Sue Ingles; Joseph G Ouzounian; Neisha Opper; Melissa L Wilson; David A Miller; Richard H Lee Journal: J Matern Fetal Neonatal Med Date: 2013-08-27
Authors: Rachel G Sinkey; Jasmin Lacevic; Tea Reljic; Iztok Hozo; Kelly S Gibson; Anthony O Odibo; Benjamin Djulbegovic; Charles J Lockwood Journal: PLoS One Date: 2018-04-25 Impact factor: 3.240