Isabella Melena1, Petter Bjornstad1, Michal Schäfer2, Kendall S Hunter3, Alex J Barker4, Amy Baumgartner1, Linh Chung1, Pattara Wiromrat1, Uyen Truong5, Jane E B Reusch6, Kristen J Nadeau7. 1. Department of Pediatric Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. 2. Department of Pediatric Cardiology, University of Colorado School of Medicine, Aurora, CO, USA. 3. Department of Pediatric Cardiology, University of Colorado School of Medicine, Aurora, CO, USA; Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. 4. Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. 5. Department of Pediatric Cardiology, University of Colorado School of Medicine, Aurora, CO, USA; Department of Pediatric Cardiology, Virginia Commonwealth University, Richmond, VA, USA. 6. Department of Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. 7. Department of Pediatric Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: kristen.nadeau@childrenscolorado.org.
Abstract
AIMS: Cardiovascular disease (CVD) is the major cause of mortality in type 1 diabetes (T1D). Biomarkers, N-terminal pro-brain natriuretic peptide (NT-proBNP) and copeptin have been linked with measures of CVD, but their relationship in adolescents with T1D remains incompletely understood. Accordingly, we examined the associations between NT-proBNP and copeptin and hemodynamic markers of central aortic stiffness in adolescents with T1D. METHODS: In this pilot study, forty-nine pubertal adolescents with T1D (mean age 17 ± 2 years, median [Q1-Q3] Tanner Stage 5 [5, 5] and HbA1c 8.5 ± 1.5%), from the EMERALD study, were assessed for copeptin and NT-proBNP, and indices of central aortic stiffness non-invasively assessed by MRI. Pearson correlations and generalized linear regression models, adjusting for confounders, were applied to examine the relationships between biomarkers and vascular measures. RESULTS: Copeptin correlated independently with both ascending aortic (AA) (β ± SE: -4.28 ± 1.87, p = 0.03) and descending aortic (DA) relative area change (RAC) (-3.41 ± 1.55, p = 0.04). NT-proBNP was independently associated with DA time-averaged wall shear stress (WSSTA) (0.87 ± 0.25, p = 0.001) and DA maximum wall shear stress (WSSmax) (2.45 ± 1.00, p = 0.02). CONCLUSIONS: Serum copeptin and NT-proBNP may be associated with central aortic stiffness and elevated WSS in youth with T1D, potentially offering a non-invasive way to identify and monitor the development of early CVD in an at-risk population.
AIMS: Cardiovascular disease (CVD) is the major cause of mortality in type 1 diabetes (T1D). Biomarkers, N-terminal pro-brain natriuretic peptide (NT-proBNP) and copeptin have been linked with measures of CVD, but their relationship in adolescents with T1D remains incompletely understood. Accordingly, we examined the associations between NT-proBNP and copeptin and hemodynamic markers of central aortic stiffness in adolescents with T1D. METHODS: In this pilot study, forty-nine pubertal adolescents with T1D (mean age 17 ± 2 years, median [Q1-Q3] Tanner Stage 5 [5, 5] and HbA1c 8.5 ± 1.5%), from the EMERALD study, were assessed for copeptin and NT-proBNP, and indices of central aortic stiffness non-invasively assessed by MRI. Pearson correlations and generalized linear regression models, adjusting for confounders, were applied to examine the relationships between biomarkers and vascular measures. RESULTS: Copeptin correlated independently with both ascending aortic (AA) (β ± SE: -4.28 ± 1.87, p = 0.03) and descending aortic (DA) relative area change (RAC) (-3.41 ± 1.55, p = 0.04). NT-proBNP was independently associated with DA time-averaged wall shear stress (WSSTA) (0.87 ± 0.25, p = 0.001) and DA maximum wall shear stress (WSSmax) (2.45 ± 1.00, p = 0.02). CONCLUSIONS: Serum copeptin and NT-proBNP may be associated with central aortic stiffness and elevated WSS in youth with T1D, potentially offering a non-invasive way to identify and monitor the development of early CVD in an at-risk population.
Authors: Petter Bjornstad; Michal Schäfer; Uyen Truong; Melanie Cree-Green; Laura Pyle; Amy Baumgartner; Yesenia Garcia Reyes; Aristides Maniatis; Sunil Nayak; R Paul Wadwa; Lorna P Browne; Jane E B Reusch; Kristen J Nadeau Journal: Circulation Date: 2018-12-18 Impact factor: 29.690
Authors: Bruno Pannier; Alain P Guérin; Sylvain J Marchais; Michel E Safar; Gérard M London Journal: Hypertension Date: 2005-03-07 Impact factor: 10.190
Authors: Kristen J Nadeau; Judith G Regensteiner; Timothy A Bauer; Mark S Brown; Jennifer L Dorosz; Amber Hull; Phil Zeitler; Boris Draznin; Jane E B Reusch Journal: J Clin Endocrinol Metab Date: 2009-11-13 Impact factor: 5.958
Authors: Shona J Livingstone; Helen C Looker; Eleanor J Hothersall; Sarah H Wild; Robert S Lindsay; John Chalmers; Stephen Cleland; Graham P Leese; John McKnight; Andrew D Morris; Donald W M Pearson; Norman R Peden; John R Petrie; Sam Philip; Naveed Sattar; Frank Sullivan; Helen M Colhoun Journal: PLoS Med Date: 2012-10-02 Impact factor: 11.069