Paul Loubet1, Yatrika Koumar2, Catherine Lechiche2, Nicolas Cellier3, Sophie Schuldiner4, Pascal Kouyoumdjian3, Jean-Philippe Lavigne5, Albert Sotto1. 1. Department of Infectious and Tropical Disease, VBMI, INSERM U1407, CHU Nîmes, Univ Montpellier, Nîmes, France. 2. Department of Infectious and Tropical Disease, CHU Nîmes, Univ Montpellier, Nîmes, France. 3. Department of Orthopedic and Trauma Surgery, CHU Nîmes, Univ Montpellier, Nîmes, France. 4. Department of Metabolic and Endocrine Disease, VBMI, INSERM U1407, CHU Nîmes, Univ Montpellier, Nîmes, France. 5. Department of Microbiology and Hospital Hygiene, VBMI, INSERM U1407, CHU Nîmes, Univ Montpellier, Nîmes, France.
Abstract
BACKGROUND: Bone and joint infections (BJIs) due to Streptococcus agalactiae are rare but has been described to increase in the past few years. The objective of this study was to describe clinical features and outcomes of cases of S. BJIs. METHODS: We conducted a retrospective analysis of adult cases of S. agalactiae BJIs that occurred between January 2009 and June 2015 in a French university hospital. The treatment success was assessed until 24 months after the end of antibiotic treatment. RESULTS: Among the 26 patients included, 20 (77%) were male, mean age was 62 years ± 13 and mean Charlson comorbidity index score was 4.9 ± 3.2. Diabetes mellitus was the most common comorbidity (n = 14, 54%). Six had PJI (Prosthetic Joint Infections), five osteosynthesis-associated infections, 11 osteomyelitis and four native septic arthritis. Eleven patients had a delayed or late infection: six with a prosthetic joint infection and five with an internal fixation device infection. Sixteen patients (62%) had a polymicrobial BJI, most commonly with Gram-positive cocci (75%) notably Staphylococcus aureus (44%). Polymicrobial infections were more frequently found in foot infections (90% vs 44%, p = 0.0184). During the two-year follow-up, three patients died (3/25, 12%) and seven (7/25, 28%) had treatment failure. CONCLUSION: Diabetes mellitus was the most common comorbidity. We observed an heterogenous management and a high rate of relapse.
BACKGROUND:Bone and joint infections (BJIs) due to Streptococcus agalactiae are rare but has been described to increase in the past few years. The objective of this study was to describe clinical features and outcomes of cases of S. BJIs. METHODS: We conducted a retrospective analysis of adult cases of S. agalactiae BJIs that occurred between January 2009 and June 2015 in a French university hospital. The treatment success was assessed until 24 months after the end of antibiotic treatment. RESULTS: Among the 26 patients included, 20 (77%) were male, mean age was 62 years ± 13 and mean Charlson comorbidity index score was 4.9 ± 3.2. Diabetes mellitus was the most common comorbidity (n = 14, 54%). Six had PJI (Prosthetic Joint Infections), five osteosynthesis-associated infections, 11 osteomyelitis and four native septic arthritis. Eleven patients had a delayed or late infection: six with a prosthetic joint infection and five with an internal fixation device infection. Sixteen patients (62%) had a polymicrobial BJI, most commonly with Gram-positive cocci (75%) notably Staphylococcus aureus (44%). Polymicrobial infections were more frequently found in foot infections (90% vs 44%, p = 0.0184). During the two-year follow-up, three patientsdied (3/25, 12%) and seven (7/25, 28%) had treatment failure. CONCLUSION:Diabetes mellitus was the most common comorbidity. We observed an heterogenous management and a high rate of relapse.
Authors: A Tazi; P C Morand; H Réglier-Poupet; N Dmytruk; A Billoët; D Antona; P Trieu-Cuot; C Poyart Journal: Clin Microbiol Infect Date: 2011-08-29 Impact factor: 8.067
Authors: S Kernéis; C Plainvert; J-P Barnier; A Tazi; N Dmytruk; B Gislain; J Loubinoux; F El Sayed; V Cattoir; N Desplaces; V Vernet; P Morand; C Poyart Journal: Eur J Clin Microbiol Infect Dis Date: 2017-04-26 Impact factor: 3.267
Authors: Joan M Nolla; Carmen Gómez-Vaquero; Xavier Corbella; Sergi Ordóñez; Carmen García-Gómez; Albert Pérez; Javier Cabo; Josep Valverde; Javier Ariza Journal: Medicine (Baltimore) Date: 2003-03 Impact factor: 1.889
Authors: Christina R Phares; Ruth Lynfield; Monica M Farley; Janet Mohle-Boetani; Lee H Harrison; Susan Petit; Allen S Craig; William Schaffner; Shelley M Zansky; Ken Gershman; Karen R Stefonek; Bernadette A Albanese; Elizabeth R Zell; Anne Schuchat; Stephanie J Schrag Journal: JAMA Date: 2008-05-07 Impact factor: 56.272
Authors: Valérie Zeller; Marina Lavigne; David Biau; Philippe Leclerc; Jean Marc Ziza; Patrick Mamoudy; Nicole Desplaces Journal: Joint Bone Spine Date: 2009-06-13 Impact factor: 4.929
Authors: E Fiaux; M Titecat; O Robineau; J Lora-Tamayo; Y El Samad; M Etienne; N Frebourg; N Blondiaux; B Brunschweiler; F Dujardin; E Beltrand; C Loiez; V Cattoir; J P Canarelli; C Hulet; M Valette; S Nguyen; F Caron; H Migaud; E Senneville Journal: BMC Infect Dis Date: 2016-10-13 Impact factor: 3.090
Authors: Mariana Albano; Melissa J Karau; Kerryl E Greenwood-Quaintance; Douglas R Osmon; Caitlin P Oravec; Daniel J Berry; Matthew P Abdel; Robin Patel Journal: Microbiol Spectr Date: 2021-07-14