Guillaume Camuset1, Sandrine Picot2, Julien Jaubert2, Gianandrea Borgherini2, Cyril Ferdynus2, Aurélie Foucher2, Jean-Christophe Maïza2, Olivier Fels2, Claire Poyart3, Patrice Poubeau2, Patrick Gérardin4. 1. Centre Hospitalier Universitaire (CHU), F-97400, SaintPierre/Saint-Denis, La Réunion, France. Electronic address: guillaume.camuset@chu-reunion.fr. 2. Centre Hospitalier Universitaire (CHU), F-97400, SaintPierre/Saint-Denis, La Réunion, France. 3. Centre National de Référence des Streptocoques, Groupe Hospitalier Cochin-Saint Vincent de Paul, Assistance Publique-Hôpitaux de Paris, F- 75679 Paris, France; Institut Cochin-Inserm; U567-UMR CNRS 10, Université Paris Descartes, F-75014 Paris, France; Unité Biologie des Bactéries Pathogènes à Gram-Positif-URA CNRS 2172, Institut Pasteur, F-75724 Paris, France. 4. Centre Hospitalier Universitaire (CHU), F-97400, SaintPierre/Saint-Denis, La Réunion, France; Centre d'Investigation Clinique 1410 (Inserm/CHU/Université de La Réunion/Union Régionale des Médecins Libéraux de l'Océan Indien), F-97410, Saint Pierre, La Réunion; UMR PIMIT "Processus Infectieux en Milieu Insulaire Tropical" (Inserm 1187, CNRS 9192, IRD 249, Université de La Réunion), plateforme technologique CYROI, F-97490, Sainte Clotilde, La Réunion.
Abstract
OBJECTIVES: While the prevalence of Group B streptococcus (GBS) colonization is important, little is known about invasive GBS (iGBS) disease in tropical areas. Our objective was to assess the burden of iGBS disease among non-pregnant adults. METHODS: A prospective hospital-based study of all non-pregnant adult patients with iGBS disease was conducted between January and December 2011 in Saint Pierre, Réunion Island, to assess its cumulative incidence rate (CIR). Capsular serotyping and multilocus sequence typing were performed to characterize GBS isolates. Case-control study was done to identify risk factors. RESULTS: The overall CIR of iGBS disease was 10.1 per 100,000. The CIR in elderly patients (≥ 65 yrs) was estimated at 40.6 per 100.000, and that of adults (15-64 years) at 6.7 per 100.000. Aboriginal origin in the Indian Ocean and overweight were both associated with iGBS disease. The most prominent clinical forms were osteo-articular and skin/soft tissue infections, as a consequence of diabetic foot. The serotypes were classic, type-Ia being the most prevalent. The hyper virulent ST-17 (CC17) was associated with type-III. CONCLUSIONS: The incidence of iGBS disease found in Réunion island is twofold that usually reported. This burden is linked to overweight in aboriginal people from the Indian Ocean.
OBJECTIVES: While the prevalence of Group B streptococcus (GBS) colonization is important, little is known about invasive GBS (iGBS) disease in tropical areas. Our objective was to assess the burden of iGBS disease among non-pregnant adults. METHODS: A prospective hospital-based study of all non-pregnant adult patients with iGBS disease was conducted between January and December 2011 in Saint Pierre, Réunion Island, to assess its cumulative incidence rate (CIR). Capsular serotyping and multilocus sequence typing were performed to characterize GBS isolates. Case-control study was done to identify risk factors. RESULTS: The overall CIR of iGBS disease was 10.1 per 100,000. The CIR in elderly patients (≥ 65 yrs) was estimated at 40.6 per 100.000, and that of adults (15-64 years) at 6.7 per 100.000. Aboriginal origin in the Indian Ocean and overweight were both associated with iGBS disease. The most prominent clinical forms were osteo-articular and skin/soft tissue infections, as a consequence of diabetic foot. The serotypes were classic, type-Ia being the most prevalent. The hyper virulent ST-17 (CC17) was associated with type-III. CONCLUSIONS: The incidence of iGBS disease found in Réunion island is twofold that usually reported. This burden is linked to overweight in aboriginal people from the Indian Ocean.
Authors: Paul Loubet; Yatrika Koumar; Catherine Lechiche; Nicolas Cellier; Sophie Schuldiner; Pascal Kouyoumdjian; Jean-Philippe Lavigne; Albert Sotto Journal: PLoS One Date: 2021-03-12 Impact factor: 3.240
Authors: Robin L P Jump; Brigid M Wilson; Daniel Baechle; Janet M Briggs; Richard E Banks; Sunah Song; Taissa Zappernick; Federico Perez Journal: JAMA Netw Open Date: 2019-12-02