| Literature DB >> 33710354 |
Abstract
Mitochondria supply cellular energy through oxidative phosphorylation and fulfill numerous additional functions that are fundamental to cellular homeostasis and stress responses. Mitochondrial malfunction, arising from inherent defects of the organelle itself, aging, or acute or chronic stress, can cause substantial damage to organismal health. For instance, mitochondrial malfunction contributes to inflammation, neurodegeneration, tumorigenesis and cardiovascular diseases. Therefore, various quality control mechanisms exist that support a functional mitochondrial organelle compartment. The CMLS Forum Reviews introduced here present a collection of articles covering select topics on basic mechanisms and pathophysiological contexts of mitochondrial damage control.Entities:
Keywords: Apoptosis; Autophagy; Mitochondria; Mitochondrial dynamics; Mitochondrial quality control; Mitochondrial retrograde response; Mitochondrial unfolded protein response; Mitophagy; Stress signaling
Mesh:
Year: 2021 PMID: 33710354 DOI: 10.1007/s00018-021-03804-y
Source DB: PubMed Journal: Cell Mol Life Sci ISSN: 1420-682X Impact factor: 9.261