| Literature DB >> 3370994 |
C Benz1, M Keniry, H Goldberg.
Abstract
The antitumor toxicity of gossypol was measured in 6 human carcinoma cell lines and compared with its toxicity against human bone marrow stem cells. Marrow cells were more resistant than any of the tumor cell lines, and tumor cell sensitivity depended on the content of intracellular LDH-M. [31P]-Magnetic resonance spectroscopy showed decline in tumor ATP levels occurring within 24 hours of treatment, suggesting that this non-invasive technique may serve as an early biochemical monitor of gossypol toxicity.Entities:
Keywords: Cancer; Clinical Research; Contraception; Contraceptive Agents, Male--pharmacodynamics; Contraceptive Agents--pharmacodynamics; Diseases; Family Planning; Gossypol--pharmacodynamics; In Vitro; Neoplasms; Research Methodology; Treatment
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Year: 1988 PMID： 3370994 DOI： 10.1016/0010-7824(88)90024-8
Source DB: PubMed Journal: Contraception ISSN： 0010-7824 Impact factor: 3.375