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Literature DB >> 33708203

Role of HCA₂ in Regulating Intestinal Homeostasis and Suppressing Colon Carcinogenesis.

Zhuoyue Li¹, Kayleen J McCafferty¹, Robert L Judd¹.

Abstract

Hydroxycarboxylic acid receptor 2 (HCA2) is vital for sensing intermediates of metabolism, including β-hydroxybutyrate and butyrate. It also regulates profound anti-inflammatory effects in various tissues, indicating that HCA2 may serve as an essential therapeutic target for mediating inflammation-associated diseases. Butyrate and niacin, endogenous and exogenous ligands of HCA2, have been reported to play an essential role in maintaining intestinal homeostasis. HCA2, predominantly expressed in diverse immune cells, is also present in intestinal epithelial cells (IECs), where it regulates the intricate communication network between diet, microbiota, and immune cells. This review summarizes the physiological role of HCA2 in intestinal homeostasis and its pathological role in intestinal inflammation and cancer.

Entities: CellLine Chemical Disease Gene Species

Keywords: HCA2; anti-inflammatory; colon cancer; intestinal homeostasis; intestinal inflammation; microbiota; mucosal immunity

Mesh：

Substances：

Year: 2021 PMID： 33708203 PMCID： PMC7940178 DOI： 10.3389/fimmu.2021.606384

Source DB: PubMed Journal: Front Immunol ISSN： 1664-3224 Impact factor: 7.561

119 in total

Review 1. Intestinal epithelial cells: regulators of barrier function and immune homeostasis.

Authors: Lance W Peterson; David Artis
Journal: Nat Rev Immunol Date: 2014-03 Impact factor: 53.106

2. Sodium Butyrate Attenuates Diarrhea in Weaned Piglets and Promotes Tight Junction Protein Expression in Colon in a GPR109A-Dependent Manner.

Authors: Wenqian Feng; Yancheng Wu; Guangxin Chen; Shoupeng Fu; Bai Li; Bingxu Huang; Dali Wang; Wei Wang; Juxiong Liu
Journal: Cell Physiol Biochem Date: 2018-06-27

3. Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine.

Authors: Santhakumar Manicassamy; Boris Reizis; Rajesh Ravindran; Helder Nakaya; Rosa Maria Salazar-Gonzalez; Yi-Chong Wang; Bali Pulendran
Journal: Science Date: 2010-08-13 Impact factor: 47.728

4. Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine.

Authors: Shin-ichiro Karaki; Retsu Mitsui; Hisayoshi Hayashi; Ikuo Kato; Hiroshi Sugiya; Toshihiko Iwanaga; John B Furness; Atsukazu Kuwahara
Journal: Cell Tissue Res Date: 2006-02-01 Impact factor: 5.249

5. Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria.

Authors: Jochem H Bernink; Lisette Krabbendam; Kristine Germar; Esther de Jong; Konrad Gronke; Michael Kofoed-Nielsen; J Marius Munneke; Mette D Hazenberg; Julien Villaudy; Christianne J Buskens; Willem A Bemelman; Andreas Diefenbach; Bianca Blom; Hergen Spits
Journal: Immunity Date: 2015-07-14 Impact factor: 31.745

Review 6. New cytokine therapeutics for inflammatory bowel disease.

Authors: P C F Stokkers; D W Hommes
Journal: Cytokine Date: 2004 Nov 21-Dec 7 Impact factor: 3.861

7. Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice.

Authors: Julien Hanson; Andreas Gille; Sabrina Zwykiel; Martina Lukasova; Björn E Clausen; Kashan Ahmed; Sorin Tunaru; Angela Wirth; Stefan Offermanns
Journal: J Clin Invest Date: 2010-07-26 Impact factor: 14.808

8. GSK256073, a selective agonist of G-protein coupled receptor 109A (GPR109A) reduces serum glucose in subjects with type 2 diabetes mellitus.

Authors: R L Dobbins; S P Shearn; R L Byerly; F F Gao; K M Mahar; A Napolitano; G J Nachbaur; A-C Le Monnier de Gouville
Journal: Diabetes Obes Metab Date: 2013-06-12 Impact factor: 6.577

4. Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling.

Authors: Jon J Kibbie; Stephanie M Dillon; Tezha A Thompson; Christine M Purba; Martin D McCarter; Cara C Wilson
Journal: Immunobiology Date: 2021-07-30 Impact factor: 3.152

4 in total

Role of HCA₂ in Regulating Intestinal Homeostasis and Suppressing Colon Carcinogenesis.

Review 1. Intestinal epithelial cells: regulators of barrier function and immune homeostasis.

2. Sodium Butyrate Attenuates Diarrhea in Weaned Piglets and Promotes Tight Junction Protein Expression in Colon in a GPR109A-Dependent Manner.

3. Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine.

4. Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine.

5. Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria.

Review 6. New cytokine therapeutics for inflammatory bowel disease.

7. Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice.

8. GSK256073, a selective agonist of G-protein coupled receptor 109A (GPR109A) reduces serum glucose in subjects with type 2 diabetes mellitus.

9. Tributyrin supplementation protects mice from acute ethanol-induced gut injury.

10. NAD biosynthesis: identification of the tryptophan to quinolinate pathway in bacteria.

Review 1. Role of Lactate in Inflammatory Processes: Friend or Foe.

2. MafK accelerates Salmonella mucosal infection through caspase-3 activation.

Review 3. Therapeutic approaches to colorectal cancer via strategies based on modulation of gut microbiota.

4. Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling.