| Literature DB >> 33707447 |
Eleanor Sinclair1, Drupad K Trivedi1, Depanjan Sarkar1, Caitlin Walton-Doyle1, Joy Milne1, Tilo Kunath2, Anouk M Rijs3, Rob M A de Bie4, Royston Goodacre5, Monty Silverdale6, Perdita Barran7.
Abstract
Parkinson's disease (PD) is a progressive neurodegenerative disorder, which is characterised by degeneration of distinct neuronal populations, including dopaminergic neurons of the substantia nigra. Here, we use a metabolomics profiling approach to identify changes to lipids in PD observed in sebum, a non-invasively available biofluid. We used liquid chromatography-mass spectrometry (LC-MS) to analyse 274 samples from participants (80 drug naïve PD, 138 medicated PD and 56 well matched control subjects) and detected metabolites that could predict PD phenotype. Pathway enrichment analysis shows alterations in lipid metabolism related to the carnitine shuttle, sphingolipid metabolism, arachidonic acid metabolism and fatty acid biosynthesis. This study shows sebum can be used to identify potential biomarkers for PD.Entities:
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Year: 2021 PMID： 33707447 PMCID： PMC7952564 DOI： 10.1038/s41467-021-21669-4
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919