Manish Anand1, Jed A Diekfuss2, Alexis B Slutsky-Ganesh3, Dustin R Grooms4, Scott Bonnette5, Kim D Barber Foss6, Christopher A DiCesare5, Jennifer L Hunnicutt7, Gregory D Myer8. 1. The SPORT Center, Division of Sports Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Emory Sports Performance And Research Center, Flowery Branch, GA, USA. Electronic address: manish.anand@emory.edu. 2. The SPORT Center, Division of Sports Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Emory Sports Performance And Research Center, Flowery Branch, GA, USA; Department of Orthopaedics, Emory School of Medicine, Emory University, Atlanta, GA, USA. 3. Department of Kinesiology, University of North Carolina at Greensboro, Greensboro, NC, USA. 4. Ohio Musculoskeletal & Neurological Institute, Ohio University, Athens, OH, USA; Division of Athletic Training, School of Applied Health Sciences and Wellness, College of Health Sciences and Professions, Ohio University, Athens, OH, USA; Division of Physical Therapy, School of Rehabilitation and Communication Sciences, College of Health Sciences and Professions, Ohio University, Grover Center, Athens, OH, USA. 5. The SPORT Center, Division of Sports Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. 6. The SPORT Center, Division of Sports Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Emory Sports Performance And Research Center, Flowery Branch, GA, USA. 7. Department of Orthopaedics, Emory School of Medicine, Emory University, Atlanta, GA, USA. 8. The SPORT Center, Division of Sports Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Emory Sports Performance And Research Center, Flowery Branch, GA, USA; Department of Orthopaedics, Emory School of Medicine, Emory University, Atlanta, GA, USA; Emory Sports Medicine Center, Atlanta, GA, USA; Department of Pediatrics and Orthopaedic Surgery, University of Cincinnati, Cincinnati, OH, USA; The Micheli Center for Sports Injury Prevention, Waltham, MA, USA.
Abstract
BACKGROUND: To better understand the neural drivers of aberrant motor control, methods are needed to identify whole brain neural correlates of isolated joints during multi-joint lower-extremity coordinated movements. This investigation aimed to identify the neural correlates of knee kinematics during a unilateral leg press task. NEW METHOD: The current study utilized an MRI-compatible motion capture system in conjunction with a lower extremity unilateral leg press task during fMRI. Knee joint kinematics and brain activity were collected concurrently and averaged range of motion were modeled as covariates to determine the neural substrates of knee out-of-plane (frontal) and in-plane (sagittal) range of motion. RESULTS: Increased out-of-plane (frontal) range of motion was associated with altered brain activity in regions important for attention, sensorimotor control, and sensorimotor integration (z >3.1, p < .05), but no such correlates were found with in-plane (sagittal) range of motion (z >3.1, p > .05). Comparison with Existing Method(s): Previous studies have either presented overall brain activation only, or utilized biomechanical data collected outside MRI in a standard biomechanics lab for identifying single-joint neural correlates. CONCLUSIONS: The study shows promise for the MRI-compatible system to capture lower-extremity biomechanical data collected concurrently during fMRI, and the present data identified potentially unique neural drivers of aberrant biomechanics. Future research can adopt these methods for patient populations with CNS-related movement disorders to identify single-joint kinematic neural correlates that may adjunctively supplement brain-body therapeutic approaches.
BACKGROUND: To better understand the neural drivers of aberrant motor control, methods are needed to identify whole brain neural correlates of isolated joints during multi-joint lower-extremity coordinated movements. This investigation aimed to identify the neural correlates of knee kinematics during a unilateral leg press task. NEW METHOD: The current study utilized an MRI-compatible motion capture system in conjunction with a lower extremity unilateral leg press task during fMRI. Knee joint kinematics and brain activity were collected concurrently and averaged range of motion were modeled as covariates to determine the neural substrates of knee out-of-plane (frontal) and in-plane (sagittal) range of motion. RESULTS: Increased out-of-plane (frontal) range of motion was associated with altered brain activity in regions important for attention, sensorimotor control, and sensorimotor integration (z >3.1, p < .05), but no such correlates were found with in-plane (sagittal) range of motion (z >3.1, p > .05). Comparison with Existing Method(s): Previous studies have either presented overall brain activation only, or utilized biomechanical data collected outside MRI in a standard biomechanics lab for identifying single-joint neural correlates. CONCLUSIONS: The study shows promise for the MRI-compatible system to capture lower-extremity biomechanical data collected concurrently during fMRI, and the present data identified potentially unique neural drivers of aberrant biomechanics. Future research can adopt these methods for patient populations with CNS-related movement disorders to identify single-joint kinematic neural correlates that may adjunctively supplement brain-body therapeutic approaches.
Authors: Mark V Paterno; Laura C Schmitt; Kevin R Ford; Mitchell J Rauh; Gregory D Myer; Bin Huang; Timothy E Hewett Journal: Am J Sports Med Date: 2010-08-11 Impact factor: 6.202
Authors: Jed A Diekfuss; Dustin R Grooms; Katharine S Nissen; Daniel K Schneider; Kim D Barber Foss; Staci Thomas; Scott Bonnette; Jonathan A Dudley; Weihong Yuan; Danielle L Reddington; Jonathan D Ellis; James Leach; Michael Gordon; Craig Lindsey; Ken Rushford; Carlee Shafer; Gregory D Myer Journal: Braz J Phys Ther Date: 2019-07-17 Impact factor: 3.377
Authors: Dustin R Grooms; Adam W Kiefer; Michael A Riley; Jonathan D Ellis; Staci Thomas; Katie Kitchen; Christopher A DiCesare; Scott Bonnette; Brooke Gadd; Kim D Barber Foss; Weihong Yuan; Paula Silva; Ryan Galloway; Jed A Diekfuss; James Leach; Kate Berz; Gregory D Myer Journal: J Sport Rehabil Date: 2018-09-03 Impact factor: 1.931
Authors: Sheri P Silfies; Jennifer M C Vendemia; Paul F Beattie; Jill Campbell Stewart; Max Jordon Journal: Pain Med Date: 2017-11-01 Impact factor: 3.750
Authors: Manish Anand; Jed A Diekfuss; Scott Bonnette; Ian Short; Matthew Hurn; Dustin R Grooms; Gregory D Myer Journal: Int J Sports Phys Ther Date: 2020-12
Authors: Lukas Jaeger; Laura Marchal-Crespo; Peter Wolf; Robert Riener; Lars Michels; Spyros Kollias Journal: Front Hum Neurosci Date: 2014-10-28 Impact factor: 3.169
Authors: Dustin R Grooms; Jed A Diekfuss; Cody R Criss; Manish Anand; Alexis B Slutsky-Ganesh; Christopher A DiCesare; Gregory D Myer Journal: PLoS One Date: 2022-08-11 Impact factor: 3.752
Authors: Stefano Di Paolo; Stefano Zaffagnini; Filippo Tosarelli; Fabrizio Aggio; Laura Bragonzoni; Alberto Grassi; Francesco Della Villa Journal: Knee Surg Sports Traumatol Arthrosc Date: 2021-09-04 Impact factor: 4.342