Literature DB >> 33704891

Parental monitoring for type 1 diabetes in genetically at-risk young children: The TEDDY study.

Laura B Smith1, Kristian F Lynch2, Kimberly A Driscoll3, Suzanne Bennett Johnson4.   

Abstract

OBJECTIVE: We examined parental diabetes monitoring behaviors in a cohort of children at increased genetic risk for type 1 diabetes. We hypothesized that being informed of a positive islet autoantibody (IA) would increase monitoring behaviors. RESEARCH DESIGN AND METHODS: The Environmental Determinants of Diabetes in the Young (TEDDY) study follows 8676 children with high-risk human leucocyte antigen-DQ genotypes from birth to age 15, including general population (GP) children and those with a first-degree relative (FDR) with diabetes. Data on parental monitoring behaviors were solicited yearly. Serum samples were tested for IA and parents were informed of child results. We examined parental monitoring behaviors during the first 7 years of TEDDY.
RESULTS: In IA- children, the most common monitoring behavior was participating in TEDDY study tasks; up to 49.8% and 44.2% of mothers and fathers, respectively, reported this. Among FDRs, 7%-10% reported watching for diabetes symptoms and 7%-9% reported monitoring the child's glucose, for mothers and fathers, respectively. After IA+ notification, all monitoring behaviors significantly increased in GP parents; only glucose monitoring increased in FDR parents and these behaviors continued for up to 4 years. FDR status, accurate diabetes risk perception, and anxiety were associated with glucose monitoring in IA+ and IA- cohorts.
CONCLUSIONS: Many parents view TEDDY participation as a way to monitor for type 1 diabetes, a benefit of enrollment in a longitudinal study with no prevention offered. IA+ notification increases short- and long-term monitoring behaviors. For IA- and IA+ children, FDR parents engage in glucose monitoring, even when not instructed to do so.
© 2021 John Wiley & Sons Ltd.

Entities:  

Keywords:  blood glucose self-monitoring; genetic screening; observational study; pediatrics; type 1 diabetes mellitus

Mesh:

Substances:

Year:  2021        PMID: 33704891      PMCID: PMC8771863          DOI: 10.1111/pedi.13173

Source DB:  PubMed          Journal:  Pediatr Diabetes        ISSN: 1399-543X            Impact factor:   3.409


  22 in total

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Review 2.  Psychological and ethical aspects of prevention trials.

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Review 3.  Clinical practice. Postpartum depression.

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4.  Maternal efforts to prevent type 1 diabetes in at-risk children.

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Journal:  Diabetes Care       Date:  2005-04       Impact factor: 19.112

5.  Disease-associated autoantibodies as surrogate markers of type 1 diabetes in young children at increased genetic risk. Childhood Diabetes in Finland Study Group.

Authors:  T Kimpimäki; P Kulmala; K Savola; P Vähäsalo; H Reijonen; J Ilonen; H K Akerblom; M Knip
Journal:  J Clin Endocrinol Metab       Date:  2000-03       Impact factor: 5.958

6.  Risk assessment for developing type 1 diabetes: intentions of behavioural changes prior to risk notification.

Authors:  C Hendrieckx; F De Smet; I Kristoffersen; C Bradley
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7.  Ketoacidosis at diagnosis of type 1 diabetes: Effect of prospective studies with newborn genetic screening and follow up of risk children.

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Journal:  Pediatr Diabetes       Date:  2017-05-23       Impact factor: 4.866

8.  Residual beta-cell function in diabetes children followed and diagnosed in the TEDDY study compared to community controls.

Authors:  Andrea K Steck; Helena Elding Larsson; Xiang Liu; Riitta Veijola; Jorma Toppari; William A Hagopian; Michael J Haller; Simi Ahmed; Beena Akolkar; Åke Lernmark; Marian J Rewers; Jeffrey P Krischer
Journal:  Pediatr Diabetes       Date:  2017-01-27       Impact factor: 3.409

9.  Factors associated with maternal-reported actions to prevent type 1 diabetes in the first year of the TEDDY study.

Authors:  Laura B Smith; Kristian F Lynch; Judith Baxter; Barbro Lernmark; Roswith Roth; Tuula Simell; Suzanne Bennett Johnson
Journal:  Diabetes Care       Date:  2013-09-16       Impact factor: 17.152

10.  My Child Is Islet Autoantibody Positive: Impact on Parental Anxiety.

Authors:  Suzanne Bennett Johnson; Kristian F Lynch; Roswith Roth; Desmond Schatz
Journal:  Diabetes Care       Date:  2017-06-29       Impact factor: 17.152

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