Sarah M Kashanian1, Andrew Y Li1, Moaath Mustafa Ali1,2, Mark E Sutherland1,3,4, Vu H Duong1,2, Bryan C Hambley5, Kyle Zacholski5, Firas El Chaer1,2,6, Noa G Holtzman1,2,7, Mohammad Imran1,2, Ciera L Patzke2,8, Jonathan Cornu8, Alison Duffy2,8,9, Amy E Dezern5, Ivana Gojo5, Kelly J Norsworthy5, Mark J Levis5, B Douglas Smith5, Maria R Baer1,2, Gabriel Ghiaur5, Ashkan Emadi1,2,10. 1. Department of Medicine, University of Maryland School of Medicine, Baltimore, MD. 2. University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD. 3. Department of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD. 4. Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD. 5. The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD. 6. Present address: Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA. 7. Present address: Immune Deficiency Cellular Therapy Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD. 8. Department of Pharmacy, University of Maryland Medical Center, Baltimore, MD. 9. University of Maryland School of Pharmacy, Baltimore, MD. 10. Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD.
Abstract
Introduction: Obesity has become increasingly prevalent worldwide and is a risk factor for many malignancies. We studied the correlation between body mass index (BMI) and the incidence of acute promyelocytic leukemia (APL), non-APL acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and control hospitalized patients without leukemia in the same community. Methods: Multi-center, retrospective analysis of 71,196 patients: APL (n=200), AML (n=437), ALL (n=103), non-leukemia hospitalized (n=70,456) admitted to University of Maryland and Johns Hopkins Cancer Centers, and University of Maryland Medical Center. Results: Patients with APL had a significantly higher unadjusted mean and median BMI (32.5 kg/m2 and 30.3 kg/m2) than those with AML (28.3 kg/m2 and 27.1 kg/m2), ALL (29.3 kg/m2 and 27.7 kg/m2), and others (29.3 kg/m2 and 27.7 kg/m2) (p<0.001). Log-transformed BMI multivariable models demonstrated that APL patients had a significantly higher adjusted mean BMI by 3.7 kg/m2 (p<0.001) or approximately 10% (p<0.01) compared to the other groups, when controlled for sex, race, and age. Conclusions: This study confirms that when controlled for sex, age, and race there is an independent association of higher BMI among patients with APL compared to patients with ALL, AML, and hospitalized individuals without leukemia in the same community.
Introduction: Obesity has become increasingly prevalent worldwide and is a risk factor for many malignancies. We studied the correlation between body mass index (BMI) and the incidence of acute promyelocytic leukemia (APL), non-APL acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and control hospitalized patients without leukemia in the same community. Methods: Multi-center, retrospective analysis of 71,196 patients: APL (n=200), AML (n=437), ALL (n=103), non-leukemia hospitalized (n=70,456) admitted to University of Maryland and Johns Hopkins Cancer Centers, and University of Maryland Medical Center. Results: Patients with APL had a significantly higher unadjusted mean and median BMI (32.5 kg/m2 and 30.3 kg/m2) than those with AML (28.3 kg/m2 and 27.1 kg/m2), ALL (29.3 kg/m2 and 27.7 kg/m2), and others (29.3 kg/m2 and 27.7 kg/m2) (p<0.001). Log-transformed BMI multivariable models demonstrated that APL patients had a significantly higher adjusted mean BMI by 3.7 kg/m2 (p<0.001) or approximately 10% (p<0.01) compared to the other groups, when controlled for sex, race, and age. Conclusions: This study confirms that when controlled for sex, age, and race there is an independent association of higher BMI among patients with APL compared to patients with ALL, AML, and hospitalized individuals without leukemia in the same community.
Entities:
Keywords:
APL; BMI; acute promyelocytic leukemia; body mass index; obesity
Authors: E K Choi; H B Park; K H Lee; J H Park; M Eisenhut; H J van der Vliet; G Kim; J I Shin Journal: Ann Oncol Date: 2018-03-01 Impact factor: 32.976
Authors: Jorge J Castillo; Flora Mulkey; Susan Geyer; Jonathan E Kolitz; William Blum; Bayard L Powell; Stephen L George; Richard A Larson; Richard M Stone Journal: Am J Hematol Date: 2015-11-26 Impact factor: 10.047
Authors: Gitanjali M Singh; Goodarz Danaei; Farshad Farzadfar; Gretchen A Stevens; Mark Woodward; David Wormser; Stephen Kaptoge; Gary Whitlock; Qing Qiao; Sarah Lewington; Emanuele Di Angelantonio; Stephen Vander Hoorn; Carlene M M Lawes; Mohammed K Ali; Dariush Mozaffarian; Majid Ezzati Journal: PLoS One Date: 2013-07-30 Impact factor: 3.240
Authors: Sarah M Kashanian; Andrew Y Li; Moaath Mustafa Ali; Mark E Sutherland; Vu H Duong; Bryan C Hambley; Kyle Zacholski; Firas El Chaer; Noa G Holtzman; Mohammad Imran; Ciera L Patzke; Jonathan Cornu; Alison Duffy; Amy E Dezern; Ivana Gojo; Kelly J Norsworthy; Mark J Levis; B Douglas Smith; Maria R Baer; Gabriel Ghiaur; Ashkan Emadi Journal: EJHaem Date: 2021-01-06
Authors: John W R Kincaid; Gretchen Weiss; Anne E Hill-Baskin; Heidi M Schmidt; Ovwoioise Omoijuanfo; Cheryl L Thompson; Rose C Beck; Nathan A Berger Journal: Obesity (Silver Spring) Date: 2022-05-24 Impact factor: 9.298
Authors: Sarah M Kashanian; Andrew Y Li; Moaath Mustafa Ali; Mark E Sutherland; Vu H Duong; Bryan C Hambley; Kyle Zacholski; Firas El Chaer; Noa G Holtzman; Mohammad Imran; Ciera L Patzke; Jonathan Cornu; Alison Duffy; Amy E Dezern; Ivana Gojo; Kelly J Norsworthy; Mark J Levis; B Douglas Smith; Maria R Baer; Gabriel Ghiaur; Ashkan Emadi Journal: EJHaem Date: 2021-01-06