Literature DB >> 33691146

The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19.

Maarten H Geurts1, Jelte van der Vaart1, Joep Beumer2, Hans Clevers3.   

Abstract

Many pathogenic viruses that affect man display species specificity, limiting the use of animal models. Studying viral biology and identifying potential treatments therefore benefits from the development of in vitro cell systems that closely mimic human physiology. In the current COVID-19 pandemic, rapid scientific insights are of the utmost importance to limit its impact on public health and society. Organoids are emerging as versatile tools to progress the understanding of SARS-CoV-2 biology and to aid in the quest for novel treatments.
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  COVID-19; SARS-CoV-2; organoid; virus

Year:  2021        PMID： 33691146      PMCID： PMC7940129          DOI： 10.1016/j.stemcr.2020.11.009

Source DB:  PubMed          Journal:  Stem Cell Reports        ISSN： 2213-6711            Impact factor:   7.765


  39 in total

1.  Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids.

Authors:  Birgitta E Michels; Mohammed H Mosa; Barbara I Streibl; Tianzuo Zhan; Constantin Menche; Khalil Abou-El-Ardat; Tahmineh Darvishi; Ewelina Członka; Sebastian Wagner; Jan Winter; Hind Medyouf; Michael Boutros; Henner F Farin
Journal:  Cell Stem Cell       Date:  2020-04-28       Impact factor: 24.633

2.  Infection of bat and human intestinal organoids by SARS-CoV-2.

Authors:  Jie Zhou; Cun Li; Xiaojuan Liu; Man Chun Chiu; Xiaoyu Zhao; Dong Wang; Yuxuan Wei; Andrew Lee; Anna Jinxia Zhang; Hin Chu; Jian-Piao Cai; Cyril Chik-Yan Yip; Ivy Hau-Yee Chan; Kenneth Kak-Yuen Wong; Owen Tak-Yin Tsang; Kwok-Hung Chan; Jasper Fuk-Woo Chan; Kelvin Kai-Wang To; Honglin Chen; Kwok Yung Yuen
Journal:  Nat Med       Date:  2020-05-13       Impact factor: 53.440

3.  Hydroxychloroquine or Chloroquine for Treatment or Prophylaxis of COVID-19: A Living Systematic Review.

Authors:  Adrian V Hernandez; Yuani M Roman; Vinay Pasupuleti; Joshuan J Barboza; C Michael White
Journal:  Ann Intern Med       Date:  2020-05-27       Impact factor: 25.391

4.  Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients.

Authors:  Salo N Ooft; Fleur Weeber; Krijn K Dijkstra; Chelsea M McLean; Sovann Kaing; Erik van Werkhoven; Luuk Schipper; Louisa Hoes; Daniel J Vis; Joris van de Haar; Warner Prevoo; Petur Snaebjornsson; Daphne van der Velden; Michelle Klein; Myriam Chalabi; Henk Boot; Monique van Leerdam; Haiko J Bloemendal; Laurens V Beerepoot; Lodewyk Wessels; Edwin Cuppen; Hans Clevers; Emile E Voest
Journal:  Sci Transl Med       Date:  2019-10-09       Impact factor: 17.956

5.  Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.

Authors:  Manli Wang; Ruiyuan Cao; Leike Zhang; Xinglou Yang; Jia Liu; Mingyue Xu; Zhengli Shi; Zhihong Hu; Wu Zhong; Gengfu Xiao
Journal:  Cell Res       Date:  2020-02-04       Impact factor: 25.617

6.  Differentiated human airway organoids to assess infectivity of emerging influenza virus.

Authors:  Jie Zhou; Cun Li; Norman Sachs; Man Chun Chiu; Bosco Ho-Yin Wong; Hin Chu; Vincent Kwok-Man Poon; Dong Wang; Xiaoyu Zhao; Lei Wen; Wenjun Song; Shuofeng Yuan; Kenneth Kak-Yuen Wong; Jasper Fuk-Woo Chan; Kelvin Kai-Wang To; Honglin Chen; Hans Clevers; Kwok-Yung Yuen
Journal:  Proc Natl Acad Sci U S A       Date:  2018-06-11       Impact factor: 11.205

7.  Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.

Authors:  Vanessa Monteil; Hyesoo Kwon; Patricia Prado; Astrid Hagelkrüys; Reiner A Wimmer; Martin Stahl; Alexandra Leopoldi; Elena Garreta; Carmen Hurtado Del Pozo; Felipe Prosper; Juan Pablo Romero; Gerald Wirnsberger; Haibo Zhang; Arthur S Slutsky; Ryan Conder; Nuria Montserrat; Ali Mirazimi; Josef M Penninger
Journal:  Cell       Date:  2020-04-24       Impact factor: 41.582

8.  The Role of Host Genetic Factors in Coronavirus Susceptibility: Review of Animal and Systematic Review of Human Literature.

Authors:  Marissa LoPresti; David B Beck; Priya Duggal; Derek A T Cummings; Benjamin D Solomon
Journal:  Am J Hum Genet       Date:  2020-08-12       Impact factor: 11.025

9.  Development of Feline Ileum- and Colon-Derived Organoids and Their Potential Use to Support Feline Coronavirus Infection.

Authors:  Gergely Tekes; Rosina Ehmann; Steeve Boulant; Megan L Stanifer
Journal:  Cells       Date:  2020-09-12       Impact factor: 6.600

10.  SARS-CoV-2 targets neurons of 3D human brain organoids.

Authors:  Anand Ramani; Lisa Müller; Philipp N Ostermann; Elke Gabriel; Pranty Abida-Islam; Andreas Müller-Schiffmann; Aruljothi Mariappan; Olivier Goureau; Henning Gruell; Andreas Walker; Marcel Andrée; Sandra Hauka; Torsten Houwaart; Alexander Dilthey; Kai Wohlgemuth; Heymut Omran; Florian Klein; Dagmar Wieczorek; Ortwin Adams; Jörg Timm; Carsten Korth; Heiner Schaal; Jay Gopalakrishnan
Journal:  EMBO J       Date:  2020-09-23       Impact factor: 11.598
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  8 in total

Review 1.  Defense of COVID-19 by Human Organoids.

Authors:  Ting Lv; Fanlu Meng; Meng Yu; Haihui Huang; Xinhua Lin; Bing Zhao
Journal:  Phenomics       Date:  2021-07-14

2.  The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research.

Authors:  Lars Muhl; Liqun He; Ying Sun; Maarja Andaloussi Mäe; Riikka Pietilä; Jianping Liu; Guillem Genové; Lei Zhang; Yuan Xie; Stefanos Leptidis; Giuseppe Mocci; Simon Stritt; Ahmed Osman; Andrey Anisimov; Karthik Amudhala Hemanthakumar; Markus Räsänen; Emil M Hansson; Johan Björkegren; Michael Vanlandewijck; Klas Blomgren; Taija Mäkinen; Xiao-Rong Peng; Yizhou Hu; Patrik Ernfors; Thomas D Arnold; Kari Alitalo; Urban Lendahl; Christer Betsholtz
Journal:  Stem Cell Reports       Date:  2022-04-21       Impact factor: 7.294

Review 3.  Human Organoids as a Promising Platform for Fighting COVID-19.

Authors:  Dong Chen; Xi Su; Haibo Chen; Siyan Chen; Yongsheng Zhao; Wei Wei
Journal:  Int J Biol Sci       Date:  2022-01-01       Impact factor: 6.580

Review 4.  When stem cells meet COVID-19: recent advances, challenges and future perspectives.

Authors:  Shasha Li; Hecheng Zhu; Ming Zhao; Weidong Liu; Lei Wang; Bin Zhu; Wen Xie; Cong Zhao; Yao Zhou; Caiping Ren; Hui Liu; Xingjun Jiang
Journal:  Stem Cell Res Ther       Date:  2022-01-10       Impact factor: 6.832

5.  Two Different Therapeutic Approaches for SARS-CoV-2 in hiPSCs-Derived Lung Organoids.

Authors:  Paola Spitalieri; Federica Centofanti; Michela Murdocca; Maria Giovanna Scioli; Andrea Latini; Silvia Di Cesare; Gennaro Citro; Antonio Rossi; Augusto Orlandi; Shane Miersch; Sachdev S Sidhu; Pier Paolo Pandolfi; Annalisa Botta; Federica Sangiuolo; Giuseppe Novelli
Journal:  Cells       Date:  2022-04-05       Impact factor: 6.600

Review 6.  100 plus years of stem cell research-20 years of ISSCR.

Authors:  Urban Lendahl
Journal:  Stem Cell Reports       Date:  2022-06-14       Impact factor: 7.294

7.  Microfluidic Tools for Enhanced Characterization of Therapeutic Stem Cells and Prediction of Their Potential Antimicrobial Secretome.

Authors:  Pasquale Marrazzo; Valeria Pizzuti; Silvia Zia; Azzurra Sargenti; Daniele Gazzola; Barbara Roda; Laura Bonsi; Francesco Alviano
Journal:  Antibiotics (Basel)       Date:  2021-06-22

8.  Air-Liquid-Interface Differentiated Human Nose Epithelium: A Robust Primary Tissue Culture Model of SARS-CoV-2 Infection.

Authors:  Bang M Tran; Samantha L Grimley; Julie L McAuley; Abderrahman Hachani; Linda Earnest; Sharon L Wong; Leon Caly; Julian Druce; Damian F J Purcell; David C Jackson; Mike Catton; Cameron J Nowell; Laura Leonie; Georgia Deliyannis; Shafagh A Waters; Joseph Torresi; Elizabeth Vincan
Journal:  Int J Mol Sci       Date:  2022-01-13       Impact factor: 5.923
  8 in total

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