Literature DB >> 33688830

Exploring the origins of nucleation.

Katarzyna Marta Zoltowska1, Lucía Chávez-Gutiérrez1,2.   

Abstract

An approach called deep mutational scanning is improving our understanding of amyloid beta aggregation.
© 2021, Zoltowska and Chávez-Gutiérrez.

Entities:  

Keywords:  Alzheimer's; S. cerevisiae; aggregation; amyloid; computational biology; deep mutagenesis; genetics; genomics; nucleation; systems biology

Mesh：

Substances：

Year:  2021        PMID： 33688830      PMCID： PMC7946419          DOI： 10.7554/eLife.67269

Source DB:  PubMed          Journal:  Elife        ISSN： 2050-084X            Impact factor:   8.140


  8 in total

1.  Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.

Authors:  Maria Szaruga; Bogdan Munteanu; Sam Lismont; Sarah Veugelen; Katrien Horré; Marc Mercken; Takaomi C Saido; Natalie S Ryan; Tatjana De Vos; Savvas N Savvides; Rodrigo Gallardo; Joost Schymkowitz; Frederic Rousseau; Nick C Fox; Carsten Hopf; Bart De Strooper; Lucía Chávez-Gutiérrez
Journal:  Cell       Date:  2017-07-27       Impact factor: 41.582

2.  Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain.

Authors:  Gunnar Brinkmalm; Wei Hong; Zemin Wang; Wen Liu; Tiernan T O'Malley; Xin Sun; Matthew P Frosch; Dennis J Selkoe; Erik Portelius; Henrik Zetterberg; Kaj Blennow; Dominic M Walsh
Journal:  Brain       Date:  2019-05-01       Impact factor: 13.501

3.  How evolutionary pressure against protein aggregation shaped chaperone specificity.

Authors:  Frederic Rousseau; Luis Serrano; Joost W H Schymkowitz
Journal:  J Mol Biol       Date:  2005-11-28       Impact factor: 5.469

4.  Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate.

Authors:  Ting Yang; Shaomin Li; Huixin Xu; Dominic M Walsh; Dennis J Selkoe
Journal:  J Neurosci       Date:  2017-01-04       Impact factor: 6.167

5.  Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.

Authors:  Maria Szaruga; Sarah Veugelen; Manasi Benurwar; Sam Lismont; Diego Sepulveda-Falla; Alberto Lleo; Natalie S Ryan; Tammaryn Lashley; Nick C Fox; Shigeo Murayama; Harrie Gijsen; Bart De Strooper; Lucía Chávez-Gutiérrez
Journal:  J Exp Med       Date:  2015-10-19       Impact factor: 14.307

6.  Elucidating the Molecular Determinants of Aβ Aggregation with Deep Mutational Scanning.

Authors:  Vanessa E Gray; Katherine Sitko; Floriane Z Ngako Kameni; Miriam Williamson; Jason J Stephany; Nicholas Hasle; Douglas M Fowler
Journal:  G3 (Bethesda)       Date:  2019-11-05       Impact factor: 3.154

7.  The genetic landscape for amyloid beta fibril nucleation accurately discriminates familial Alzheimer's disease mutations.

Authors:  Mireia Seuma; Andre J Faure; Marta Badia; Ben Lehner; Benedetta Bolognesi
Journal:  Elife       Date:  2021-02-01       Impact factor: 8.140

Review 8.  The amyloid hypothesis of Alzheimer's disease at 25 years.

Authors:  Dennis J Selkoe; John Hardy
Journal:  EMBO Mol Med       Date:  2016-06-01       Impact factor: 12.137
  8 in total

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