Kwangwoo Nam1, Nayoung Kim2,3, Hyun Joo Song4, Gwang Ho Baik5, Suck Chei Choi6, Hyun Jin Kim7, Ju Yup Lee8, Kyung Sik Park8, Sun-Young Park9, Seun Ja Park10. 1. Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea. 2. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, 13620, Korea. nakim49@snu.ac.kr. 3. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea. nakim49@snu.ac.kr. 4. Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea. 5. Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea. 6. Department of Internal Medicine, Digestive Disease Research Institute, Wonkwang University College of Medicine, Iksan, Korea. 7. Department of Internal Medicine and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea. 8. Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. 9. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. 10. Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
Abstract
BACKGROUND: The overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS) is associated with more severe gastrointestinal (GI) symptoms and lower quality of life. However, the gender differences in FD-IBS overlap remain unclear. This study aimed to investigate the gender differences in patients with FD-IBS overlap. METHODS: Controls and cases were prospectively enrolled from July 2019 to June 2020 at nine tertiary referral centers. The patients underwent esophagogastroduodenoscopy, and their symptoms were evaluated using a questionnaire including GI symptom-related items and the Hospital Anxiety Depression Scale (HADS). FD and IBS were diagnosed according to the Rome IV criteria, and the clinical characteristics of the FD-IBS overlap group were compared with those of the FD-only or IBS-only group. RESULTS: Among 667 subjects (334 healthy controls, 168 with FD-only, 37 with IBS-only, 128 with FD-IBS overlap), the FD-IBS overlap group (19.2%) showed a higher rate of preference for dairy products, a higher rate of history of Helicobacter pylori eradication, and higher HADS scores than the non-overlap group (P < 0.05). In the FD-IBS overlap group, men complained of reflux symptom and loose/watery stools more than women (P < 0.05), whereas women showed more severe GI symptoms, especially epigastric pain/burning symptoms, and higher depression scores than men (all P < 0.05). CONCLUSIONS: FD-IBS overlap patients are associated with severe upper GI symptoms and depression compared to non-overlap patients. Moreover, women with FD-IBS overlap experience more severe GI and depression symptoms than men.
BACKGROUND: The overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS) is associated with more severe gastrointestinal (GI) symptoms and lower quality of life. However, the gender differences in FD-IBS overlap remain unclear. This study aimed to investigate the gender differences in patients with FD-IBS overlap. METHODS: Controls and cases were prospectively enrolled from July 2019 to June 2020 at nine tertiary referral centers. The patients underwent esophagogastroduodenoscopy, and their symptoms were evaluated using a questionnaire including GI symptom-related items and the Hospital Anxiety Depression Scale (HADS). FD and IBS were diagnosed according to the Rome IV criteria, and the clinical characteristics of the FD-IBS overlap group were compared with those of the FD-only or IBS-only group. RESULTS: Among 667 subjects (334 healthy controls, 168 with FD-only, 37 with IBS-only, 128 with FD-IBS overlap), the FD-IBS overlap group (19.2%) showed a higher rate of preference for dairy products, a higher rate of history of Helicobacter pylori eradication, and higher HADS scores than the non-overlap group (P < 0.05). In the FD-IBS overlap group, men complained of reflux symptom and loose/watery stools more than women (P < 0.05), whereas women showed more severe GI symptoms, especially epigastric pain/burning symptoms, and higher depression scores than men (all P < 0.05). CONCLUSIONS: FD-IBS overlap patients are associated with severe upper GI symptoms and depression compared to non-overlap patients. Moreover, women with FD-IBS overlap experience more severe GI and depression symptoms than men.
Authors: Lesley A Houghton; Margaret Heitkemper; Michael Crowell; Anton Emmanuel; Albena Halpert; James A McRoberts; Brenda Toner Journal: Gastroenterology Date: 2016-02-15 Impact factor: 22.682
Authors: Christopher J Black; Peter A Paine; Anurag Agrawal; Imran Aziz; Maria P Eugenicos; Lesley A Houghton; Pali Hungin; Ross Overshott; Dipesh H Vasant; Sheryl Rudd; Richard C Winning; Maura Corsetti; Alexander C Ford Journal: Gut Date: 2022-07-07 Impact factor: 31.793