Literature DB >> 3368516

Metabolism of sennosides by human intestinal bacteria.

M Hattori1, T Namba, T Akao, K Kobashi.   

Abstract

During the course of studies on the metabolism of sennosides by human intestinal bacteria, an enzyme which takes part in the reduction of sennosides and sennidins was originally isolated from Peptostreptococcus intermedius. This enzyme catalyzed the electron transfer from NADH to FAD, FMN or benzyl viologen, which reduced nonenzymatically sennosides and sennidins to 8-glucosyl-rhein anthrone and rhein anthrone, respectively.

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Year:  1988        PMID： 3368516     DOI： 10.1159/000138437

Source DB:  PubMed          Journal:  Pharmacology        ISSN： 0031-7012            Impact factor:   2.547


  11 in total

1.  Isolation of a human intestinal anaerobe, Bifidobacterium sp. strain SEN, capable of hydrolyzing sennosides to sennidins.

Authors:  T Akao; Q M Che; K Kobashi; L Yang; M Hattori; T Namba
Journal:  Appl Environ Microbiol       Date:  1994-03       Impact factor: 4.792

2.  Promotion of intestinal peristalsis by Bifidobacterium spp. capable of hydrolysing sennosides in mice.

Authors:  Mitsuharu Matsumoto; Atsushi Ishige; Yuka Yazawa; Manami Kondo; Koji Muramatsu; Kenji Watanabe
Journal:  PLoS One       Date:  2012-02-22       Impact factor: 3.240

3.  Daiokanzoto (Da-Huang-Gan-Cao-Tang) is an effective laxative in gut microbiota associated with constipation.

Authors:  Kento Takayama; Chiho Takahara; Norihiko Tabuchi; Nobuyuki Okamura
Journal:  Sci Rep       Date:  2019-03-07       Impact factor: 4.379

4.  Phylobioactive hotspots in plant resources used to treat Chagas disease.

Authors:  Andrea Salm; Sandhya R Krishnan; Marta Collu; Ombeline Danton; Matthias Hamburger; Marco Leonti; Giovanna Almanza; Jürg Gertsch
Journal:  iScience       Date:  2021-03-15

5.  Evaluation of the Amounts of Sennosides A and B in Rhubarb-containing Kampo Medicines to Create a Ranking of Kampo Medicines for Appropriate Selection of Laxatives.

Authors:  Kakuyou Ogawa; Ai Tashima; Keisuke Okazaki; Osamu Morinaga
Journal:  J Anus Rectum Colon       Date:  2021-07-29

Review 6.  Potential roles of gut microbes in biotransformation of natural products: An overview.

Authors:  Yucui Zhao; Xinqin Zhong; Junyuan Yan; Congying Sun; Xin Zhao; Xiaoying Wang
Journal:  Front Microbiol       Date:  2022-09-29       Impact factor: 6.064

7.  In Silico Studies on Sennidines-Natural Dianthrones from Senna.

Authors:  Sebastian Szymanski; Irena Majerz
Journal:  Biology (Basel)       Date:  2021-05-26

Review 8.  Clinical pharmacokinetics of diacerein.

Authors:  P Nicolas; M Tod; C Padoin; O Petitjean
Journal:  Clin Pharmacokinet       Date:  1998-11       Impact factor: 6.447

9.  Metabolism and pharmacokinetics of san-huang-xie-xin-tang, a polyphenol-rich chinese medicine formula, in rats and ex-vivo antioxidant activity.

Authors:  Chi-Sheng Shia; Yu-Chi Hou; Shin-Hun Juang; Shang-Yuan Tsai; Pei-Hsun Hsieh; Lu-Ching Ho; Pei-Dawn Lee Chao
Journal:  Evid Based Complement Alternat Med       Date:  2011-06-07       Impact factor: 2.629

Review 10.  Mechanisms of gastrointestinal microflora on drug metabolism in clinical practice.

Authors:  Chaonan Sun; Ling Chen; Zhu Shen
Journal:  Saudi Pharm J       Date:  2019-10-24       Impact factor: 4.330
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