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Literature DB >> 3368504

Single-dose kinetics of nifedipine in rat plasma and brain.

P K Janicki¹, D Siembab, E A Paulo, P Krzaścik.

Abstract

Nifedipine concentrations in plasma and brain tissue of rats were assayed from 5 min to 4 h after an intravenous injection of 6 mg/kg body weight. Samples of rat plasma and homogenized brain tissue were extracted under sodium light with a dichloromethane-pentane mixture. Analyses were done by high-performance liquid chromatography on a reverse-phase C18 column with electrochemical detection. The peak concentration of nifedipine in brain obtained after 10 min was 37 micrograms/g wet weight tissue, the half-life was 75 min. Apparently, nifedipine can easily cross the blood-brain barrier in the rat.

Entities: Chemical Species

Mesh：

Substances：
Dosage Forms
Nifedipine

Year: 1988 PMID： 3368504 DOI： 10.1159/000138382

Source DB: PubMed Journal: Pharmacology ISSN： 0031-7012 Impact factor: 2.547

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Cited

9 in total

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Authors: Chris K Cain; Ashley M Blouin; Mark Barad
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3. Activation of steroid-sensitive TRPM3 channels potentiates glutamatergic transmission at cerebellar Purkinje neurons from developing rats.

Authors: Paula A Zamudio-Bulcock; Julie Everett; Christian Harteneck; C Fernando Valenzuela
Journal: J Neurochem Date: 2011-09-28 Impact factor: 5.372

Single-dose kinetics of nifedipine in rat plasma and brain.

Review 1. Central sympathoinhibitory effects of calcium channel blockers.

2. L-type voltage-gated calcium channels are required for extinction, but not for acquisition or expression, of conditional fear in mice.

3. Activation of steroid-sensitive TRPM3 channels potentiates glutamatergic transmission at cerebellar Purkinje neurons from developing rats.

4. Effect of calcium antagonists on regional cerebral blood flow in transplanted rat brain tumors.

5. The L-type calcium channel blocker nifedipine impairs extinction, but not reduced contingency effects, in mice.

6. Nifedipine facilitates neurotransmitter release independently of calcium channels.

7. Brain-penetrant calcium channel blockers are associated with a reduced incidence of neuropsychiatric disorders.

8. Reduction of morphine dependence and potentiation of analgesia by chronic co-administration of nifedipine.

9. Nrf2 activation: a potential strategy for the prevention of acute mountain sickness.