Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases.

Literature DB >> 33680284

The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases.

Abstract

Cardiovascular disease (CVD) is the leading cause of death in the world. The mechanism behind CVDs has been studied for decades; however, the pathogenesis is still controversial. Mitochondrial homeostasis plays an essential role in maintaining the normal function of the cardiovascular system. The alterations of any protein function in mitochondria may induce abnormal mitochondrial quality control and unexpected mitochondrial dysfunction, leading to CVDs. Posttranslational modifications (PTMs) affect protein function by reversibly changing their conformation. This review summarizes how common and novel PTMs influence the development of CVDs by regulating mitochondrial quality control. It provides not only ideas for future research on the mechanism of some types of CVDs but also ideas for CVD treatments with therapeutic potential.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Mitochondrial Proteins

Year: 2021 PMID： 33680284 PMCID： PMC7910068 DOI： 10.1155/2021/6635836

Source DB: PubMed Journal: Oxid Med Cell Longev ISSN： 1942-0994 Impact factor: 6.543

151 in total

1. miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1.

Authors: Jian-Xun Wang; Jian-Qin Jiao; Qian Li; Bo Long; Kun Wang; Jin-Ping Liu; Yan-Rui Li; Pei-Feng Li
Journal: Nat Med Date: 2010-12-26 Impact factor: 53.440

2. SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

Authors: Jeongsoon Park; Yue Chen; Daniel X Tishkoff; Chao Peng; Minjia Tan; Lunzhai Dai; Zhongyu Xie; Yi Zhang; Bernadette M M Zwaans; Mary E Skinner; David B Lombard; Yingming Zhao
Journal: Mol Cell Date: 2013-06-27 Impact factor: 17.970

3. The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury.

Authors: Lingchen Gao; Yichao Zhao; Jie He; Yang Yan; Longwei Xu; Nan Lin; Qingqi Ji; Renyang Tong; Yanan Fu; Yu Gao; Yuanyuan Su; Ancai Yuan; Ben He; Jun Pu
Journal: J Genet Genomics Date: 2017-12-29 Impact factor: 4.275

4. Parkin Regulates Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury by Targeting Cyclophilin-D.

Authors: Teng Sun; Wei Ding; Tao Xu; Xiang Ao; Tao Yu; Mengyang Li; Ying Liu; Xuejuan Zhang; Lin Hou; Jianxun Wang
Journal: Antioxid Redox Signal Date: 2019-09-26 Impact factor: 8.401

Review 5. The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition.

Authors: Jaclyn R Gareau; Christopher D Lima
Journal: Nat Rev Mol Cell Biol Date: 2010-12 Impact factor: 94.444

6. The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy.

Authors: Nagalingam R Sundaresan; Vinodkumar B Pillai; Don Wolfgeher; Sadhana Samant; Prabhakaran Vasudevan; Vishwas Parekh; Hariharasundaram Raghuraman; John M Cunningham; Madhu Gupta; Mahesh P Gupta
Journal: Sci Signal Date: 2011-07-19 Impact factor: 8.192

7. Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.

Authors: Minjia Tan; Chao Peng; Kristin A Anderson; Peter Chhoy; Zhongyu Xie; Lunzhi Dai; Jeongsoon Park; Yue Chen; He Huang; Yi Zhang; Jennifer Ro; Gregory R Wagner; Michelle F Green; Andreas S Madsen; Jessica Schmiesing; Brett S Peterson; Guofeng Xu; Olga R Ilkayeva; Michael J Muehlbauer; Thomas Braulke; Chris Mühlhausen; Donald S Backos; Christian A Olsen; Peter J McGuire; Scott D Pletcher; David B Lombard; Matthew D Hirschey; Yingming Zhao
Journal: Cell Metab Date: 2014-04-01 Impact factor: 27.287

The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases.

1. miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1.

2. SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

3. The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury.

4. Parkin Regulates Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury by Targeting Cyclophilin-D.

Review 5. The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition.

6. The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy.

7. Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.

Review 8. Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning.

Review 9. Functions and mechanisms of lysine crotonylation.

10. Dynamics of Telomere Rejuvenation during Chemical Induction to Pluripotent Stem Cells.

Review 1. Mitochondrial Proteins as Source of Cancer Neoantigens.